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HAMAP rule MF_00165

General rule information [?]

Accession	MF_00165
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 29)
Name	Thymidylate_kinase
Scope(s)	Bacteria Archaea
Template(s)	P0A720 (KTHY_ECOLI); P9WKE1 (KTHY_MYCTU); O69169 (KTHY_YERPE); [ Recover all ]
Triggered by	HAMAP; MF_00165 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	KTHY
case <OC:Bacteria>
Protein name	RecName: Full=Thymidylate kinase; EC=2.7.4.9; AltName: Full=dTMP kinase;
end case
case <OC:Archaea>
Protein name	RecName: Full=Probable thymidylate kinase; EC=2.7.4.9; AltName: Full=dTMP kinase;
end case
Gene name	Name=tmk;

Comments [?]

case <OC:Bacteria>
FUNCTION	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
end case
CATALYTIC ACTIVITY	Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517, ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.4.9;
SIMILARITY	Belongs to the thymidylate kinase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0004798; Molecular function:thymidylate kinase activity

GO:0006235; Biological process:dTTP biosynthetic process

Cross-references [?]

Features [?]

From: KTHY_ECOLI (P0A720)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

G-x-[DE]-[GACT]-x-G-K-[ST]

Additional information [?]

Size range	188-245 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	Possible inactive tmk in AERPE and TREPA due to a defective ATP-binding site; not shown in alignment. Possible wrong start in RHOBA.