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HAMAP rule MF_00165

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General rule information [?]

Accession MF_00165
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 29)
Name Thymidylate_kinase
Scope(s) Bacteria
Template(s) P0A720 (KTHY_ECOLI); P9WKE1 (KTHY_MYCTU); O69169 (KTHY_YERPE); [ Recover all ]
Triggered by HAMAP; MF_00165 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KTHY
case <OC:Bacteria>
Protein name RecName: Full=Thymidylate kinase;
AltName: Full=dTMP kinase;
end case
case <OC:Archaea>
Protein name RecName: Full=Probable thymidylate kinase;
AltName: Full=dTMP kinase;
end case
Gene name Name=tmk;

Comments [?]

case <OC:Bacteria>
FUNCTIONPhosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
end case
CATALYTIC ACTIVITY Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517, ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=;
SIMILARITYBelongs to the thymidylate kinase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004798; Molecular function:thymidylate kinase activity
GO:0006235; Biological process:dTTP biosynthetic process

Cross-references [?]

Pfam PF02223; Thymidylate_kin; 1;
NCBIfam TIGR00041; DTMP_kinase; 1;

Features [?]

From: KTHY_ECOLI (P0A720)
Key From To Description Tag Condition FTGroup
BINDING 10 17 /ligand="ATP"

Additional information [?]

Size range 188-245 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible inactive tmk in AERPE and TREPA due to a defective ATP-binding site; not shown in alignment. Possible wrong start in RHOBA.

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