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Annotation rule MF_00165
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General rule information [?]

Accession MF_00165
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 26)
Name Thymidylate_kinase
Scope
Bacteria
Archaea
Templates P0A720 (KTHY_ECOLI); P9WKE1 (KTHY_MYCTU); O69169 (KTHY_YERPE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KTHY
case <OC:Bacteria>
Protein name
RecName: Full=Thymidylate kinase;
EC 2.7.4.9;
AltName: Full=dTMP kinase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable thymidylate kinase;
EC 2.7.4.9;
AltName: Full=dTMP kinase;
end case
Gene name
tmk

Comments [?]

case <OC:Bacteria>
Function Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
end case
Catalytic activity RHEA:13517: ATP + dTMP = ADP + dTDP
EC 2.7.4.9
Similarity Belongs to the thymidylate kinase family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004798; Molecular function: thymidylate kinase activity.
GO:0006235; Biological process: dTTP biosynthetic process.

Cross-references [?]

Pfam PF02223; Thymidylate_kin; 1;
TIGRFAMs TIGR00041; DTMP_kinase; 1;
PROSITE PS01331; THYMIDYLATE_KINASE; 1;

Features [?]

From: KTHY_ECOLI (P0A720)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     10     17       ATP     G-x-[DE]-[GACT]-x-G-K-[ST]  

Additional information [?]

Size range 188-245 amino acids
Related rules None
Fusion None
Comments Possible inactive tmk in AERPE and TREPA due to a defective ATP-binding site; not shown in alignment. Possible wrong start in RHOBA.