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HAMAP rule MF_00167

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General rule information [?]

Accession MF_00167
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 23)
Name CsrA
Scope(s) Bacteria
Template(s) P69913 (CSRA_ECOLI); P33911 (CSRA_BACSU); O69078 (CSRA_PSEAE); P0DPC3 (CSRA1_PSEPH); [ Recover all ]
Triggered by HAMAP; MF_00167 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CSRA
case <OC:Gammaproteobacteria>
Protein name RecName: Full=Translational regulator CsrA;
AltName: Full=Carbon storage regulator;
Protein name RecName: Full=Translational regulator CsrA;
end case
Gene name Name=csrA;

Comments [?]

case <OC:Gammaproteobacteria>
FUNCTIONA key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
FUNCTIONA translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
end case
SUBUNITHomodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.
SIMILARITYBelongs to the CsrA/RsmA family.

Keywords [?]

case <OC:Gammaproteobacteria>
end case
case not <OC:Gammaproteobacteria>
Bacterial flagellum biogenesis
end case
Translation regulation

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0048027; Molecular function:mRNA 5'-UTR binding
GO:0045947; Biological process:negative regulation of translational initiation
case <OCellular component:Gammaproteobacteria>
GO:0006109; Biological process:regulation of carbohydrate metabolic process
GO:0045948; Biological process:positive regulation of translational initiation
end case
case not <OCellular component:Gammaproteobacteria>
GO:1902208; Biological process:regulation of bacterial-type flagellum assembly
end case

Cross-references [?]

Pfam PF02599; CsrA; 1;
NCBIfam TIGR00202; CsrA; 1;

Features [?]

Additional information [?]

Size range 57-135 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The ancestral operon is thought to be Fliw-CsrA, where CsrA is dedicated to controlling flagellar assembly and motility. Rounds of gene loss and re-acquisition in Gammaproteobacteria have lead to CsrA being repurposed for a larger role in translation control. See PubMed:25833324, Vakulskas et al., Microbiol. Mol. Biol. Rev. 79:193-224(2015) for a review.

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