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HAMAP rule MF_00167

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General rule information [?]

Accession MF_00167
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 23)
Name CsrA
Scope
Bacteria
Templates P69913 (CSRA_ECOLI); P33911 (CSRA_BACSU); O69078 (CSRA_PSEAE); P0DPC3 (CSRA1_PSEPH): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CSRA
case <OC:Gammaproteobacteria>
Protein name
RecName: Full=Translational regulator CsrA;
AltName: Full=Carbon storage regulator;
else
Protein name
RecName: Full=Translational regulator CsrA;
end case
Gene name
csrA

Comments [?]

case <OC:Gammaproteobacteria>
Function A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
else
Function A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
end case
Subunit Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.
Subcellular location Cytoplasm.
Similarity Belongs to the CsrA/RsmA family.

Keywords [?]

case <OC:Gammaproteobacteria>
Activator
end case
case not <OC:Gammaproteobacteria>
Bacterial flagellum biogenesis
end case
Cytoplasm
Repressor
RNA-binding
Translation regulation

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0048027; Molecular function: mRNA 5'-UTR binding.
GO:0045947; Biological process: negative regulation of translational initiation.
case <OC:Gammaproteobacteria>
GO:0006109; Biological process: regulation of carbohydrate metabolic process.
GO:0045948; Biological process: positive regulation of translational initiation.
end case
case not <OC:Gammaproteobacteria>
GO:1902208; Biological process: regulation of bacterial-type flagellum assembly.
end case

Cross-references [?]

Pfam PF02599; CsrA; 1;
NCBIfam TIGR00202; CsrA; 1;

Additional information [?]

Size range 57-135 amino acids
Related rules None
Fusion None
Comments The ancestral operon is thought to be Fliw-CsrA, where CsrA is dedicated to controlling flagellar assembly and motility. Rounds of gene loss and re-acquisition in Gammaproteobacteria have lead to CsrA being repurposed for a larger role in translation control. See PubMed:25833324, Vakulskas et al., Microbiol. Mol. Biol. Rev. 79:193-224(2015) for a review.


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