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Annotation rule MF_00172
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General rule information [?]

Accession MF_00172
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 29)
Name Meth_synth
Template P25665 (METE_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase;
AltName: Full=Cobalamin-independent methionine synthase;
AltName: Full=Methionine synthase, vitamin-B12 independent isozyme;
Gene name

Comments [?]

Function Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Catalytic activity RHEA:21196: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.
Similarity Belongs to the vitamin-B12 independent methionine synthase family.

Keywords [?]

Gene Ontology [?]

GO:0003871; Molecular function: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.

Cross-references [?]

Pfam PF08267; Meth_synt_1; 1;
PF01717; Meth_synt_2; 1;
PIRSF PIRSF000382; MeTrfase_B12_ind; 1;
TIGRFAMs TIGR01371; Met_syn_B12ind; 1;

Features [?]

From: METE_ECOLI (P25665)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     641     641       Zinc     H  
METAL     643     643       Zinc     C  
METAL     726     726       Zinc     C  

Additional information [?]

Size range 734-792 amino acids
Related rules MF_00288 (METE)
Fusion None