HAMAP rule MF_00175

Accession	MF_00175
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 27)

Name

ClpX

Scope

Bacteria

Templates

P0A6H1 (CLPX_ECOLI); O25926 (CLPX_HELPY): [Recover all]

Triggered by

HAMAP; MF_00175 (Get profile general information and statistics)

Identifier

CLPX

Protein name

RecName: Full=ATP-dependent Clp protease ATP-binding subunit ClpX;

Gene name

clpX

Function	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Subunit	Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
Similarity	Belongs to the ClpX chaperone family.

ATP-binding
Chaperone
Metal-binding
Nucleotide-binding
Zinc

GO:0005524; Molecular function: ATP binding.
GO:0051082; Molecular function: unfolded protein binding.
GO:0006457; Biological process: protein folding.

Pfam	PF00004; AAA; 1;
	PF06689; zf-C4_ClpX; 1;
TIGRFAMs	TIGR00382; clpX; 1;
PROSITE	PS51902; CLPX_ZB; 1; trigger=PRU01250;

From: CLPX_ECOLI (P0A6H1)

Key

From

To

Description

Tag

Condition

FTGroup

BINDING

120

127

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

[PS]-[ST]-G-x-G-K-T-[LYFV]

BINDING

15

15

/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105

C

1

BINDING

18

18

/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105

C

1

BINDING

37

37

/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105

C

1

BINDING

40

40

/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105

C

1

Size range	380-500 amino acids
Related rules	MF_00249 (HSLU)
Fusion	None
Comments	Unknown insert in BIFLO

View rule in raw text format (no links)