HAMAP rule MF_00175
General rule information
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| Accession | MF_00175 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 28) |
| Name | ClpX |
| Scope(s) |
Bacteria |
| Template(s) | P0A6H1 (CLPX_ECOLI); O25926 (CLPX_HELPY); [ Recover all ] |
| Triggered by |
HAMAP; MF_00175 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CLPX |
| Protein name | RecName: Full=ATP-dependent Clp protease ATP-binding subunit ClpX; |
| Gene name | Name=clpX; |
Comments
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| FUNCTION | ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. |
| SUBUNIT | Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. |
| SIMILARITY | Belongs to the ClpX chaperone family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0051082; Molecular function:unfolded protein binding |
| GO:0006457; Biological process:protein folding |
Cross-references
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| Pfam | PF00004; AAA; 1; |
| Pfam | PF06689; zf-C4_ClpX; 1; |
| NCBIfam | TIGR00382; clpX; 1; |
| PROSITE | PS51902; CLPX_ZB; 1; |
Features
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| From: CLPX_ECOLI (P0A6H1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 120 | 127 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[PS]-[ST]-G-x-G-K-T-[LYFV] | ||||||||
| BINDING | 15 | 15 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 18 | 18 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 37 | 37 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 40 | 40 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 380-500 amino acids |
| Related rules |
MF_00249 |
| Fusion | Nter: None Cter: None |
| Comments | Unknown insert in BIFLO |