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HAMAP rule MF_00175

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General rule information [?]

Accession MF_00175
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 27)
Name ClpX
Templates P0A6H1 (CLPX_ECOLI); O25926 (CLPX_HELPY): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=ATP-dependent Clp protease ATP-binding subunit ClpX;
Gene name

Comments [?]

Function ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Subunit Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
Similarity Belongs to the ClpX chaperone family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0051082; Molecular function: unfolded protein binding.
GO:0006457; Biological process: protein folding.

Cross-references [?]

Pfam PF00004; AAA; 1;
PF06689; zf-C4_ClpX; 1;
TIGRFAMs TIGR00382; clpX; 1;
PROSITE PS51902; CLPX_ZB; 1; trigger=PRU01250;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     120     127       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [PS]-[ST]-G-x-G-K-T-[LYFV]  
BINDING     15     15       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     18     18       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     37     37       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     40     40       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 380-500 amino acids
Related rules MF_00249 (HSLU)
Fusion None
Comments Unknown insert in BIFLO