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Annotation rule MF_00181 |
Accession | MF_00181 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 34) |
Name | Cytosol_peptidase_M17 |
Scope | Bacteria
Archaea |
Templates | P68767 (AMPA_ECOLI); P27888 (AMPA_RICPR): [Recover all] |
Triggered by |
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Protein name |
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Gene name |
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Function | Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. |
Catalytic activity | Reaction=Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.; EC=3.4.11.1; |
Reaction=Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.; EC=3.4.11.10; | |
Cofactor | Mn(2+) Note: Binds 2 manganese ions per subunit. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the peptidase M17 family. |
From: AMPA_ECOLI (P68767) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 282 | 282 | K | |||||||||
ACT_SITE | 356 | 356 | R | |||||||||
METAL | 270 | 270 | Manganese 2 | K | ||||||||
METAL | 275 | 275 | Manganese 1 | D | ||||||||
METAL | 275 | 275 | Manganese 2 | D | ||||||||
METAL | 293 | 293 | Manganese 2 | D | ||||||||
METAL | 352 | 352 | Manganese 1 | D | ||||||||
METAL | 354 | 354 | Manganese 1 | E | ||||||||
METAL | 354 | 354 | Manganese 2 | E |
Size range | 445-524 amino acids |
Related rules | MF_00504 (PEPB) |
Fusion | None |
Comments | Possible wrong C-terminal sequence in MYCSA |