HAMAP rule MF_00182
General rule information
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| Accession | MF_00182 |
| Dates | 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 31) |
| Name | Formyl_trans |
| Scope(s) |
Bacteria |
| Template(s) | P23882 (FMT_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00182 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FMT |
| Protein name | RecName: Full=Methionyl-tRNA formyltransferase; EC=2.1.2.9; |
| Gene name | Name=fmt; |
Comments
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| FUNCTION | Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. |
| CATALYTIC ACTIVITY | Reaction=(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl- tRNA(fMet); Xref=Rhea:RHEA:24380, Rhea:RHEA-COMP:9952, Rhea:RHEA- COMP:9953, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, ChEBI:CHEBI:78530, ChEBI:CHEBI:78844, ChEBI:CHEBI:195366; EC=2.1.2.9; |
| SIMILARITY | Belongs to the Fmt family. |
Keywords
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Gene Ontology
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| GO:0004479; Molecular function:methionyl-tRNA formyltransferase activity |
| GO:0019988; Biological process:charged-tRNA amino acid modification |
Cross-references
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| Pfam | PF02911; Formyl_trans_C; 1; |
| Pfam | PF00551; Formyl_trans_N; 1; |
| NCBIfam | TIGR00460; fmt; 1; |
| PROSITE | PS00373; GART; 1; |
Features
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| From: FMT_ECOLI (P23882) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 113 | 116 | /ligand="(6S)-5,6,7,8-tetrahydrofolate" /ligand_id="ChEBI:CHEBI:57453" |
[GS]-x-L-P | ||||||||
Additional information
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| Size range | 250-380 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Divergent RALN1 not shown in alignment |