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HAMAP rule MF_00182

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General rule information [?]

Accession MF_00182
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 31)
Name Formyl_trans
Scope(s) Bacteria
Template(s) P23882 (FMT_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00182 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FMT
Protein name RecName: Full=Methionyl-tRNA formyltransferase;
Gene name Name=fmt;

Comments [?]

FUNCTIONAttaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
CATALYTIC ACTIVITY Reaction=(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl- tRNA(fMet); Xref=Rhea:RHEA:24380, Rhea:RHEA-COMP:9952, Rhea:RHEA- COMP:9953, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, ChEBI:CHEBI:78530, ChEBI:CHEBI:78844, ChEBI:CHEBI:195366; EC=;
SIMILARITYBelongs to the Fmt family.

Keywords [?]

Gene Ontology [?]

GO:0004479; Molecular function:methionyl-tRNA formyltransferase activity
GO:0019988; Biological process:charged-tRNA amino acid modification

Cross-references [?]

Pfam PF02911; Formyl_trans_C; 1;
Pfam PF00551; Formyl_trans_N; 1;
NCBIfam TIGR00460; fmt; 1;

Features [?]

From: FMT_ECOLI (P23882)
Key From To Description Tag Condition FTGroup
BINDING 113 116 /ligand="(6S)-5,6,7,8-tetrahydrofolate"

Additional information [?]

Size range 250-380 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Divergent RALN1 not shown in alignment

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