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HAMAP rule MF_00187

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General rule information [?]

Accession MF_00187
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 27)
Name FdhD
Scope(s) Bacteria
Template(s) P32177 (FDHD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00187 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FDHD
case <FTTag:persulfide>
Protein name RecName: Full=Sulfur carrier protein FdhD;
Protein name RecName: Full=Protein FdhD;
end case
Gene name Name=fdhD;

Comments [?]

case <FTTag:persulfide>
FUNCTIONRequired for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
FUNCTIONRequired for formate dehydrogenase (FDH) activity.
end case
SIMILARITYBelongs to the FdhD family.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
case <FTTag:persulfide>
GO:0097163; Molecular function:sulfur carrier activity
end case
GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process

Cross-references [?]

Pfam PF02634; FdhD-NarQ; 1;
NCBIfam TIGR00129; fdhD_narQ; 1;
PIRSF PIRSF015626; FdhD; 1;

Features [?]

From: FDHD_ECOLI (P32177)
Key From To Description Tag Condition FTGroup
BINDING 260 265 /ligand="Mo-bis(molybdopterin guanine dinucleotide)"
ACT_SITE 121 121 /note="Cysteine persulfide intermediate" persulfide C

Additional information [?]

Size range 220-340 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In some species, the catalytic cysteine loop is missing. In these species, FdhD may function as a chaperone involved in FDH maturation. See PubMed=25649206.

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