HAMAP rule MF_00187

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00187
Accession	MF_00187
Dates	28-FEB-2005 (Created) 01-JUN-2023 (Last updated, Version 23)
Name	FdhD
Scope(s)	Bacteria Archaea
Template(s)	P32177; [ Recover all ]
Triggered by	HAMAP; MF_00187 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	FDHD
case <FTTag:persulfide>
Protein name	RecName: Full=Sulfur carrier protein FdhD;
else
Protein name	RecName: Full=Protein FdhD;
end case
Gene name	Name=fdhD;

Comments [?]

case <FTTag:persulfide>
FUNCTION	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
else
FUNCTION	Required for formate dehydrogenase (FDH) activity.
end case
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the FdhD family.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
case <FTTag:persulfide>
GO:0097163; Molecular function:sulfur carrier activity
end case
GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process

Cross-references [?]

Features [?]

From: FDHD_ECOLI (P32177)

Key

From

Description

Tag

Condition

FTGroup

BINDING

260

265

/ligand="Mo-bis(molybdopterin guanine dinucleotide)"
/ligand_id="ChEBI:CHEBI:60539"

F-x-[KR]-x-x-[KR]

ACT_SITE

121

/note="Cysteine persulfide intermediate"

persulfide

Additional information [?]

Size range	220-340 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	In some species, the catalytic cysteine loop is missing. In these species, FdhD may function as a chaperone involved in FDH maturation. See PubMed=25649206.