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Annotation rule MF_00187
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General rule information [?]

Accession MF_00187
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 23)
Name FdhD
Template P32177 (FDHD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:persulfide>
Protein name
RecName: Full=Sulfur carrier protein FdhD;
Protein name
RecName: Full=Protein FdhD;
end case
Gene name

Comments [?]

case <FTTag:persulfide>
Function Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
Function Required for formate dehydrogenase (FDH) activity.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the FdhD family.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
case <FTTag:persulfide>
GO:0097163; Molecular function: sulfur carrier activity.
end case
GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.

Cross-references [?]

Pfam PF02634; FdhD-NarQ; 1;
TIGRFAMs TIGR00129; fdhD_narQ; 1;
PIRSF PIRSF015626; FdhD; 1;

Features [?]

From: FDHD_ECOLI (P32177)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     260     265       Mo-bisPGD binding     F-x-[KR]-x-x-[KR]  
ACT_SITE     121     121       Cysteine persulfide intermediate   persulfide   C  

Additional information [?]

Size range 220-340 amino acids
Related rules None
Fusion None
Comments In some species, the catalytic cysteine loop is missing. In these species, FdhD may function as a chaperone involved in FDH maturation. See PubMed=25649206.