HAMAP rule MF_00187
General rule information
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Accession | MF_00187 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 27) |
Name | FdhD |
Scope(s) |
Bacteria Archaea |
Template(s) | P32177 (FDHD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00187 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | FDHD |
case <FTTag:persulfide> | |
Protein name | RecName: Full=Sulfur carrier protein FdhD; |
else | |
Protein name | RecName: Full=Protein FdhD; |
end case | |
Gene name | Name=fdhD; |
Comments
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case <FTTag:persulfide> | |
FUNCTION | Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. |
else | |
FUNCTION | Required for formate dehydrogenase (FDH) activity. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the FdhD family. |
Keywords
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Gene Ontology
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GO:0005737; Cellular component:cytoplasm | |
case <FTTag:persulfide> | |
GO:0097163; Molecular function:sulfur carrier activity | |
end case | |
GO:0006777; Biological process:Mo-molybdopterin cofactor biosynthetic process |
Cross-references
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Pfam | PF02634; FdhD-NarQ; 1; |
NCBIfam | TIGR00129; fdhD_narQ; 1; |
PIRSF | PIRSF015626; FdhD; 1; |
Features
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From: FDHD_ECOLI (P32177) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 260 | 265 | /ligand="Mo-bis(molybdopterin guanine dinucleotide)" /ligand_id="ChEBI:CHEBI:60539" |
F-x-[KR]-x-x-[KR] | ||||||||
ACT_SITE | 121 | 121 | /note="Cysteine persulfide intermediate" | persulfide | C |
Additional information
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Size range | 220-340 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | In some species, the catalytic cysteine loop is missing. In these species, FdhD may function as a chaperone involved in FDH maturation. See PubMed=25649206. |