HAMAP rule MF_00188
General rule information
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| Accession | MF_00188 |
| Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 48) |
| Name | Pept_M48_protease_HtpX |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P23894 (HTPX_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00188 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HTPX |
| case <OC:Gammaproteobacteria> | |
| Protein name | RecName: Full=Protease HtpX; EC=3.4.24.-; AltName: Full=Heat shock protein HtpX; |
| else | |
| Protein name | RecName: Full=Protease HtpX homolog; EC=3.4.24.-; |
| end case | |
| Gene name | Name=htpX; |
Comments
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| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the peptidase M48B family. |
Keywords
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| case <OC:Gammaproteobacteria> | |
| Stress response | |
| end case | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Hydrolase | |
| Membrane | |
| Metal-binding | |
| Metalloprotease | |
| Protease | |
| Transmembrane | |
| Zinc | |
| Transmembrane helix | |
Gene Ontology
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| GO:0004222; Molecular function:metalloendopeptidase activity |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01435; Peptidase_M48; 1; |
| PROSITE | PS00142; ZINC_PROTEASE; 1; |
| General | Transmembrane; -; 3-5; |
Features
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| From: HTPX_ECOLI (P23894) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 140 | 140 | E | |||||||||
| BINDING | 139 | 139 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | ||||||||
| BINDING | 143 | 143 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | ||||||||
| BINDING | 222 | 222 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
E | ||||||||
Additional information
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| Size range | 258-366 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in ARCFU and METTH. Possible C-terminal frameshift in METTH. Divergent duplicate htpX sequence in PYRHO: PH1588. Not induced by heat shock in Streptococcus gordonii. |