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HAMAP rule MF_00188

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General rule information [?]

Accession MF_00188
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 48)
Name Pept_M48_protease_HtpX
Scope
Bacteria
Archaea
Template P23894 (HTPX_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HTPX
case <OC:Gammaproteobacteria>
Protein name
RecName: Full=Protease HtpX;
EC 3.4.24.-;
AltName: Full=Heat shock protein HtpX;
else
Protein name
RecName: Full=Protease HtpX homolog;
EC 3.4.24.-;
end case
Gene name
htpX

Comments [?]

Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the peptidase M48B family.

Keywords [?]

case <OC:Gammaproteobacteria>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0004222; Molecular function: metalloendopeptidase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01435; Peptidase_M48; 1;
PROSITE PS00142; ZINC_PROTEASE; 1;

Computed features [?]

General Transmembrane; -; 3-5; trigger=yes;

Features [?]

From: HTPX_ECOLI (P23894)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     140     140             E  
BINDING     139     139       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H  
BINDING     143     143       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H  
BINDING     222     222       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     E  

Additional information [?]

Size range 258-366 amino acids
Related rules None
Fusion None
Comments Possible wrong start in ARCFU and METTH. Possible C-terminal frameshift in METTH. Divergent duplicate htpX sequence in PYRHO: PH1588. Not induced by heat shock in Streptococcus gordonii.