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Annotation rule MF_00188
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General rule information [?]

Accession MF_00188
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 46)
Name Pept_M48_protease_HtpX
Scope
Bacteria
Archaea
Template P23894 (HTPX_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HTPX
case <OC:Gammaproteobacteria>
Protein name
RecName: Full=Protease HtpX;
EC 3.4.24.-;
AltName: Full=Heat shock protein HtpX;
else
Protein name
RecName: Full=Protease HtpX homolog;
EC 3.4.24.-;
end case
Gene name
htpX

Comments [?]

Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the peptidase M48B family.

Keywords [?]

case <OC:Gammaproteobacteria>
Stress response
end case
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Transmembrane
Zinc
Transmembrane helix

Gene Ontology [?]

GO:0004222; Molecular function: metalloendopeptidase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01435; Peptidase_M48; 1;
PROSITE PS00142; ZINC_PROTEASE; 1;

Computed features [?]

General Transmembrane; -; 3-5; trigger=yes;

Features [?]

From: HTPX_ECOLI (P23894)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     140     140             E  
METAL     139     139       Zinc; catalytic     H  
METAL     143     143       Zinc; catalytic     H  
METAL     222     222       Zinc; catalytic     E  

Additional information [?]

Size range 258-366 amino acids
Related rules None
Fusion None
Comments Possible wrong start in ARCFU and METTH. Possible C-terminal frameshift in METTH. Divergent duplicate htpX sequence in PYRHO: PH1588. Not induced by heat shock in Streptococcus gordonii.


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