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HAMAP rule MF_00188

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General rule information [?]

Accession MF_00188
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 48)
Name Pept_M48_protease_HtpX
Scope(s) Bacteria
Archaea
Template(s) P23894 (HTPX_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00188 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HTPX
case <OC:Gammaproteobacteria>
Protein name RecName: Full=Protease HtpX;
                 EC=3.4.24.-;
AltName: Full=Heat shock protein HtpX;
else
Protein name RecName: Full=Protease HtpX homolog;
                 EC=3.4.24.-;
end case
Gene name Name=htpX;

Comments [?]

COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the peptidase M48B family.

Keywords [?]

case <OC:Gammaproteobacteria>
Stress response
end case
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Transmembrane
Zinc
Transmembrane helix

Gene Ontology [?]

GO:0004222; Molecular function:metalloendopeptidase activity
GO:0008270; Molecular function:zinc ion binding
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01435; Peptidase_M48; 1;
PROSITE PS00142; ZINC_PROTEASE; 1;
General Transmembrane; -; 3-5;

Features [?]

From: HTPX_ECOLI (P23894)
Key From To Description Tag Condition FTGroup
ACT_SITE 140 140 E
BINDING 139 139 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
H
BINDING 143 143 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
H
BINDING 222 222 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
E

Additional information [?]

Size range 258-366 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong start in ARCFU and METTH. Possible C-terminal frameshift in METTH. Divergent duplicate htpX sequence in PYRHO: PH1588. Not induced by heat shock in Streptococcus gordonii.



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