HAMAP rule MF_00188
General rule information
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Accession | MF_00188 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 48) |
Name | Pept_M48_protease_HtpX |
Scope | Bacteria
Archaea |
Template | P23894 (HTPX_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Gammaproteobacteria>
Protein name |
|
else
Protein name |
|
end case
Gene name |
|
Comments
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Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity | Belongs to the peptidase M48B family. |
Keywords
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case <OC:Gammaproteobacteria>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case
Cell membrane
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Transmembrane
Zinc
Transmembrane helix
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Transmembrane
Zinc
Transmembrane helix
Gene Ontology
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GO:0004222; Molecular function: metalloendopeptidase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0005886; Cellular component: plasma membrane.
GO:0008270; Molecular function: zinc ion binding.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 3-5; trigger=yes; |
Features
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From: HTPX_ECOLI (P23894) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 140 | 140 | E | |||||||||
BINDING | 139 | 139 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | ||||||||
BINDING | 143 | 143 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | ||||||||
BINDING | 222 | 222 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | E |
Additional information
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Size range | 258-366 amino acids |
Related rules | None |
Fusion | None |
Comments | Possible wrong start in ARCFU and METTH. Possible C-terminal frameshift in METTH. Divergent duplicate htpX sequence in PYRHO: PH1588. Not induced by heat shock in Streptococcus gordonii. |