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Annotation rule MF_00190
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General rule information [?]

Accession MF_00190
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 38)
Name Cardiolipin_synth_ClsA
Scope
Bacteria; Proteobacteria
Template P0A6H8 (CLSA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CLSA
Protein name
RecName: Full=Cardiolipin synthase A;
Short=CL synthase;
EC 2.7.8.-;
Gene name
clsA

Comments [?]

Function Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Catalytic activity RHEA:31451: 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS50035; PLD; 2; trigger=PRU00153;
Pfam PF13091; PLDc_2; 0-2;
PF13396; PLDc_N; 0-1;
PF00614; PLDc; 0-2;
TIGRFAMs TIGR04265; bac_cardiolipin; 1;

Computed features [?]

General Transmembrane; -; 2-3; trigger=yes;

Features [?]

From: CLSA_ECOLI (P0A6H8)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     224     224             H  
ACT_SITE     226     226             K  
ACT_SITE     231     231             D  
ACT_SITE     404     404             H  
ACT_SITE     406     406             K  
ACT_SITE     411     411             D  

Additional information [?]

Size range 449-532 amino acids
Related rules None
Fusion None
Comments This HAMAP is now restricted to the ClsA sub-subfamily (Proteobacteria).