HAMAP rule MF_00190
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00190 |
| Accession | MF_00190 |
| Dates | 28-FEB-2005 (Created)
27-AUG-2024 (Last updated, Version 31) |
| Name | Cardiolipin_synth_ClsA |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0A6H8; [ Recover all ] |
| Triggered by |
HAMAP; MF_00190 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CLSA |
| Protein name | RecName: Full=Cardiolipin synthase A; Short=CL synthase; EC=2.7.8.-; |
| Gene name | Name=clsA; |
Comments
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| FUNCTION | Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. |
| CATALYTIC ACTIVITY | Reaction=2 a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716; |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Lipid biosynthesis | |
| Lipid metabolism | |
| Membrane | |
| Phospholipid biosynthesis | |
| Phospholipid metabolism | |
| Transferase | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups |
| GO:0008654; Biological process:phospholipid biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| PROSITE | PS50035; PLD; 2; |
| Pfam | PF13091; PLDc_2; 0-2; |
| Pfam | PF13396; PLDc_N; 0-1; |
| Pfam | PF00614; PLDc; 0-2; |
| NCBIfam | TIGR04265; bac_cardiolipin; 1; |
| General | Transmembrane; -; 2-3; |
Features
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| From: CLSA_ECOLI (P0A6H8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 224 | 224 | H | |||||||||
| ACT_SITE | 226 | 226 | K | |||||||||
| ACT_SITE | 231 | 231 | D | |||||||||
| ACT_SITE | 404 | 404 | H | |||||||||
| ACT_SITE | 406 | 406 | K | |||||||||
| ACT_SITE | 411 | 411 | D | |||||||||
Additional information
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| Size range | 449-532 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | This HAMAP is now restricted to the ClsA sub-subfamily (Pseudomonadota). |