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HAMAP rule MF_00190

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General rule information [?]

Accession MF_00190
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 40)
Name Cardiolipin_synth_ClsA
Scope(s) Bacteria
Template(s) P0A6H8 (CLSA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00190 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CLSA
Protein name RecName: Full=Cardiolipin synthase A;
                 Short=CL synthase;
Gene name Name=clsA;

Comments [?]

FUNCTIONCatalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
CATALYTIC ACTIVITY Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups
GO:0008654; Biological process:phospholipid biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

PROSITE PS50035; PLD; 2;
Pfam PF13091; PLDc_2; 0-2;
Pfam PF13396; PLDc_N; 0-1;
Pfam PF00614; PLDc; 0-2;
NCBIfam TIGR04265; bac_cardiolipin; 1;
General Transmembrane; -; 2-3;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 224 224 H
ACT_SITE 226 226 K
ACT_SITE 231 231 D
ACT_SITE 404 404 H
ACT_SITE 406 406 K
ACT_SITE 411 411 D

Additional information [?]

Size range 449-532 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments This HAMAP is now restricted to the ClsA sub-subfamily (Pseudomonadota).

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