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HAMAP rule MF_00204

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General rule information [?]

Accession MF_00204
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 37)
Name UvrB
Scope(s) Bacteria
Template(s) P56981 (UVRB_BACCA); P0A8F8 (UVRB_ECOLI); Q56243 (UVRB_THET8); [ Recover all ]
Triggered by HAMAP; MF_00204 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier UVRB
Protein name RecName: Full=UvrABC system protein B;
                 Short=Protein UvrB;
AltName: Full=Excinuclease ABC subunit B;
Gene name Name=uvrB;

Comments [?]

FUNCTIONThe UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
SUBUNITForms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
DOMAINThe beta-hairpin motif is involved in DNA binding.
SIMILARITYBelongs to the UvrB family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0009381; Molecular function:excinuclease ABC activity
GO:0006281; Biological process:DNA repair
GO:0006289; Biological process:nucleotide-excision repair
GO:0009432; Biological process:SOS response
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00271; Helicase_C; 1;
Pfam PF04851; ResIII; 1;
Pfam PF02151; UVR; 1;
NCBIfam TIGR00631; Uvrb; 1;
PROSITE PS50151; UVR; 0-1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 39 46 /ligand="ATP"
MOTIF 92 115 /note="Beta-hairpin"

Additional information [?]

Size range 645-709 amino acids
Related rules None
Fusion Nter: None Cter: None

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