HAMAP rule MF_00205
General rule information
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| Accession | MF_00205 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 38) |
| Name | UvrA |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A698 (UVRA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00205 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | UVRA |
| Protein name | RecName: Full=UvrABC system protein A; Short=UvrA protein; AltName: Full=Excinuclease ABC subunit A; |
| Gene name | Name=uvrA; |
Comments
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| FUNCTION | The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. |
| SUBUNIT | Forms a heterotetramer with UvrB during the search for lesions. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the ABC transporter superfamily. UvrA family. |
Keywords
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| Cytoplasm | |
| DNA damage | |
| SOS response | |
| Excision nuclease | |
| DNA repair | |
| DNA excision | |
| ATP-binding | |
| Nucleotide-binding | |
| DNA-binding | |
| Repeat | |
| case <FTTag:zinc> | |
| Metal-binding | |
| Zinc | |
| Zinc-finger | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| GO:0003677; Molecular function:DNA binding | |
| GO:0009381; Molecular function:excinuclease ABC activity | |
| case <FTTag:zinc> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0006281; Biological process:DNA repair | |
| GO:0006289; Biological process:nucleotide-excision repair | |
| GO:0009432; Biological process:SOS response | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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| Pfam | PF00005; ABC_tran; 1; |
| NCBIfam | TIGR00630; Uvra; 1; |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1-2; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 1-2; |
Features
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| From: UVRA_ECOLI (P0A698) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | 310 | 587 | /note="ABC transporter 1" | |||||||||
| DOMAIN | 607 | 937 | /note="ABC transporter 2" | |||||||||
| BINDING | 31 | 38 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-S-G-S-G-K-S | ||||||||
| ZN_FING | 253 | 280 | /note="C4-type" | zinc | C-x(2,3)-[CH]-x(20)-C-x(2)-C | |||||||
| BINDING | 640 | 647 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-S-G-[GS]-G-K-S | ||||||||
| ZN_FING | 740 | 766 | /note="C4-type" | zinc | C-x(2)-C-x(19)-C-x(2)-C | |||||||
Additional information
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| Size range | 900-1100 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Internal duplication in CHLPN and CHLTR. These sequences were not used in the alignment as both half of these sequences are divergent compared to other uvrA |