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HAMAP rule MF_00205

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General rule information [?]

Accession MF_00205
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 38)
Name UvrA
Scope(s) Bacteria
Template(s) P0A698 (UVRA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00205 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier UVRA
Protein name RecName: Full=UvrABC system protein A;
                 Short=UvrA protein;
AltName: Full=Excinuclease ABC subunit A;
Gene name Name=uvrA;

Comments [?]

FUNCTIONThe UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
SUBUNITForms a heterotetramer with UvrB during the search for lesions.
SIMILARITYBelongs to the ABC transporter superfamily. UvrA family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0009381; Molecular function:excinuclease ABC activity
case <FTTag:zinc>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0006281; Biological process:DNA repair
GO:0006289; Biological process:nucleotide-excision repair
GO:0009432; Biological process:SOS response
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00005; ABC_tran; 1;
NCBIfam TIGR00630; Uvra; 1;

Features [?]

From: UVRA_ECOLI (P0A698)
Key From To Description Tag Condition FTGroup
DOMAIN 310 587 /note="ABC transporter 1"
DOMAIN 607 937 /note="ABC transporter 2"
BINDING 31 38 /ligand="ATP"
ZN_FING 253 280 /note="C4-type" zinc C-x(2,3)-[CH]-x(20)-C-x(2)-C
BINDING 640 647 /ligand="ATP"
ZN_FING 740 766 /note="C4-type" zinc C-x(2)-C-x(19)-C-x(2)-C

Additional information [?]

Size range 900-1100 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Internal duplication in CHLPN and CHLTR. These sequences were not used in the alignment as both half of these sequences are divergent compared to other uvrA

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