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Annotation rule MF_00205
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General rule information [?]

Accession MF_00205
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 35)
Name UvrA
Scope
Bacteria
Archaea
Template P0A698 (UVRA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
UVRA
Protein name
RecName: Full=UvrABC system protein A;
Short=UvrA protein;
AltName: Full=Excinuclease ABC subunit A;
Gene name
uvrA

Comments [?]

Function The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
Subunit Forms a heterotetramer with UvrB during the search for lesions.
Subcellular location Cytoplasm.
Similarity Belongs to the ABC transporter superfamily. UvrA family.

Keywords [?]

Cytoplasm
DNA damage
SOS response
Excision nuclease
DNA repair
DNA excision
ATP-binding
Nucleotide-binding
DNA-binding
Repeat
case <FTTag:zinc>
Metal-binding
Zinc
Zinc-finger
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0009381; Molecular function: excinuclease ABC activity.
case <FTTag:zinc>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0006281; Biological process: DNA repair.
GO:0006289; Biological process: nucleotide-excision repair.
GO:0009432; Biological process: SOS response.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00005; ABC_tran; 1;
TIGRFAMs TIGR00630; Uvra; 1;
PROSITE PS00211; ABC_TRANSPORTER_1; 1-2;
PS50893; ABC_TRANSPORTER_2; 1-2;

Features [?]

From: UVRA_ECOLI (P0A698)
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     310     587       ABC transporter 1        
DOMAIN     607     937       ABC transporter 2        
NP_BIND     31     38       ATP     G-x-S-G-S-G-K-S  
ZN_FING     253     280       C4-type   zinc   C-x(2,3)-[CH]-x(20)-C-x(2)-C  
NP_BIND     640     647       ATP     G-x-S-G-[GS]-G-K-S  
ZN_FING     740     766       C4-type   zinc   C-x(2)-C-x(19)-C-x(2)-C  

Additional information [?]

Size range 900-1100 amino acids
Related rules None
Fusion None
Comments Internal duplication in CHLPN and CHLTR. These sequences were not used in the alignment as both half of these sequences are divergent compared to other uvrA


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