HAMAP rule MF_00205
General rule information
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Accession | MF_00205 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 38) |
Name | UvrA |
Scope(s) |
Bacteria Archaea |
Template(s) | P0A698 (UVRA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00205 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | UVRA |
Protein name | RecName: Full=UvrABC system protein A; Short=UvrA protein; AltName: Full=Excinuclease ABC subunit A; |
Gene name | Name=uvrA; |
Comments
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FUNCTION | The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. |
SUBUNIT | Forms a heterotetramer with UvrB during the search for lesions. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the ABC transporter superfamily. UvrA family. |
Keywords
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Cytoplasm | |
DNA damage | |
SOS response | |
Excision nuclease | |
DNA repair | |
DNA excision | |
ATP-binding | |
Nucleotide-binding | |
DNA-binding | |
Repeat | |
case <FTTag:zinc> | |
Metal-binding | |
Zinc | |
Zinc-finger | |
end case |
Gene Ontology
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GO:0005524; Molecular function:ATP binding | |
GO:0003677; Molecular function:DNA binding | |
GO:0009381; Molecular function:excinuclease ABC activity | |
case <FTTag:zinc> | |
GO:0008270; Molecular function:zinc ion binding | |
end case | |
GO:0006281; Biological process:DNA repair | |
GO:0006289; Biological process:nucleotide-excision repair | |
GO:0009432; Biological process:SOS response | |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00005; ABC_tran; 1; |
NCBIfam | TIGR00630; Uvra; 1; |
PROSITE | PS00211; ABC_TRANSPORTER_1; 1-2; |
PROSITE | PS50893; ABC_TRANSPORTER_2; 1-2; |
Features
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From: UVRA_ECOLI (P0A698) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | 310 | 587 | /note="ABC transporter 1" | |||||||||
DOMAIN | 607 | 937 | /note="ABC transporter 2" | |||||||||
BINDING | 31 | 38 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-S-G-S-G-K-S | ||||||||
ZN_FING | 253 | 280 | /note="C4-type" | zinc | C-x(2,3)-[CH]-x(20)-C-x(2)-C | |||||||
BINDING | 640 | 647 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-S-G-[GS]-G-K-S | ||||||||
ZN_FING | 740 | 766 | /note="C4-type" | zinc | C-x(2)-C-x(19)-C-x(2)-C |
Additional information
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Size range | 900-1100 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Internal duplication in CHLPN and CHLTR. These sequences were not used in the alignment as both half of these sequences are divergent compared to other uvrA |