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Annotation rule MF_00207
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General rule information [?]

Accession MF_00207
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 23)
Name PPase_C
Scope
Bacteria
Archaea
Templates P37487 (PPAC_BACSU); Q58025 (PPAC_METJA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PPAC
Protein name
RecName: Full=Probable manganese-dependent inorganic pyrophosphatase;
EC 3.6.1.1;
AltName: Full=Pyrophosphate phospho-hydrolase;
Short=PPase;
Gene name
ppaC

Comments [?]

Catalytic activity RHEA:24576: diphosphate + H2O = H(+) + 2 phosphate
EC 3.6.1.1
case <FTGroup:1>
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the PPase class C family.

Keywords [?]

Cytoplasm
Hydrolase
case <FTGroup:1>
Manganese
Metal-binding
end case

Gene Ontology [?]

GO:0004427; Molecular function: inorganic diphosphatase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01368; DHH; 1;
PF02833; DHHA2; 1;

Features [?]

From: PPAC_BACSU (P37487)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     9     9       Manganese 1     H   1
METAL     13     13       Manganese 1     D   1
METAL     15     15       Manganese 2     D   1
METAL     75     75       Manganese 1     D   1
METAL     75     75       Manganese 2     D   1
METAL     97     97       Manganese 2     H   1
METAL     149     149       Manganese 2     D   1

Additional information [?]

Size range 307-336 amino acids
Related rules None
Fusion None
Comments The sequence of ppaC in THEMA is interrupted by a 130-residue insert that contains 2 CBS domains.


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