HAMAP rule MF_00209

General rule information [?]

Accession	MF_00209
Dates	1-JUN-2001 (Created) 13-JAN-2023 (Last updated, Version 36)

Name	Inorganic_PPase

Scope

Bacteria

Archaea

Templates

P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC); P80562 (IPYR_NOSS1); P9WI55 (IPYR_MYCTU): [Recover all]

Triggered by

HAMAP; MF_00209 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

IPYR

Protein name

RecName:		Full=Inorganic pyrophosphatase;
		EC 3.6.1.1;
AltName:		Full=Pyrophosphate phospho-hydrolase;
		Short=PPase;

Gene name

ppa

Comments [?]

Function	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Catalytic activity	RHEA:24576: diphosphate + H2O = H(+) + 2 phosphate EC 3.6.1.1
Cofactor	Mg(2+)
Subunit	Homohexamer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the PPase family.

Keywords [?]

Cytoplasm
Hydrolase
Magnesium
Metal-binding

Gene Ontology [?]

GO:0004427; Molecular function: inorganic diphosphate phosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00719; Pyrophosphatase; 1;
PROSITE	PS00387; PPASE; 1;

Features [?]

case <OC:Actinomycetota>

From: IPYR_MYCTU (P9WI55)

Key From To Description Tag Condition FTGroup

ACT_SITE 89 89 Proton acceptor D

BINDING 8 8 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 E

BINDING 52 52 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

BINDING 57 57 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

BINDING 57 57 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 D

BINDING 84 84 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3 D

BINDING 89 89 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

BINDING 89 89 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3 D

end case

BINDING 16 16 /ligand="substrate K

BINDING 30 30 /ligand="substrate R

BINDING 42 42 /ligand="substrate Y

BINDING 126 126 /ligand="substrate Y

case not <OC:Actinomycetota>

From: IPYR_ECOLI (P0A7A9)

BINDING 66 66 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

BINDING 71 71 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

BINDING 71 71 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 D

BINDING 103 103 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 D

end case

Additional information [?]

Size range	158-215 amino acids
Related rules	None
Fusion	None

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