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HAMAP rule MF_00209

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General rule information [?]

Accession MF_00209
Dates 1-JUN-2001 (Created)
13-JAN-2023 (Last updated, Version 36)
Name Inorganic_PPase
Scope
Bacteria
Archaea
Templates P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC); P80562 (IPYR_NOSS1); P9WI55 (IPYR_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IPYR
Protein name
RecName: Full=Inorganic pyrophosphatase;
EC 3.6.1.1;
AltName: Full=Pyrophosphate phospho-hydrolase;
Short=PPase;
Gene name
ppa

Comments [?]

Function Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Catalytic activity RHEA:24576: diphosphate + H2O = H(+) + 2 phosphate
EC 3.6.1.1
Cofactor Mg(2+)
Subunit Homohexamer.
Subcellular location Cytoplasm.
Similarity Belongs to the PPase family.

Keywords [?]


Gene Ontology [?]

GO:0004427; Molecular function: inorganic diphosphate phosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00719; Pyrophosphatase; 1;
PROSITE PS00387; PPASE; 1;

Features [?]

case <OC:Actinomycetota>
From: IPYR_MYCTU (P9WI55)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     89     89       Proton acceptor     D  
BINDING     8     8       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     E  
BINDING     52     52       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     57     57       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     57     57       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     84     84       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3     D  
BINDING     89     89       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     89     89       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3     D  
end case
BINDING     16     16       /ligand="substrate     K  
BINDING     30     30       /ligand="substrate     R  
BINDING     42     42       /ligand="substrate     Y  
BINDING     126     126       /ligand="substrate     Y  
case not <OC:Actinomycetota>
From: IPYR_ECOLI (P0A7A9)
BINDING     66     66       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     71     71       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     71     71       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     103     103       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
end case

Additional information [?]

Size range 158-215 amino acids
Related rules None
Fusion None