HAMAP rule MF_00209
General rule information
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Accession | MF_00209 |
Dates | 1-JUN-2001 (Created) 13-JAN-2023 (Last updated, Version 36) |
Name | Inorganic_PPase |
Scope | Bacteria
Archaea |
Templates | P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC); P80562 (IPYR_NOSS1); P9WI55 (IPYR_MYCTU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. |
Catalytic activity | RHEA:24576: diphosphate + H2O = H(+) + 2 phosphate
EC 3.6.1.1 |
Cofactor | Mg(2+) |
Subunit | Homohexamer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the PPase family. |
Keywords
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Gene Ontology
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GO:0004427; Molecular function: inorganic diphosphate phosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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case <OC:Actinomycetota>
From: IPYR_MYCTU (P9WI55) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 89 | 89 | Proton acceptor | D | ||||||||
BINDING | 8 | 8 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 | E | ||||||||
BINDING | 52 | 52 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | D | ||||||||
BINDING | 57 | 57 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | D | ||||||||
BINDING | 57 | 57 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 | D | ||||||||
BINDING | 84 | 84 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3 | D | ||||||||
BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | D | ||||||||
BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3 | D |
end case
BINDING | 16 | 16 | /ligand="substrate | K | ||||||||
BINDING | 30 | 30 | /ligand="substrate | R | ||||||||
BINDING | 42 | 42 | /ligand="substrate | Y | ||||||||
BINDING | 126 | 126 | /ligand="substrate | Y |
case not <OC:Actinomycetota>
From: IPYR_ECOLI (P0A7A9) | ||||||||||||
BINDING | 66 | 66 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | D | ||||||||
BINDING | 71 | 71 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | D | ||||||||
BINDING | 71 | 71 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2 | D | ||||||||
BINDING | 103 | 103 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1 | D |
end case
Additional information
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Size range | 158-215 amino acids |
Related rules | None |
Fusion | None |