Annotation rule MF_00209
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General rule information [?]

Accession MF_00209
Dates 1-JUN-2001 (Created)
13-SEP-2016 (Last updated, Version 30)
Name Inorganic_PPase
Scope Bacteria
Archaea
Templates P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC); P80562 (IPYR_NOSS1); P9WI55 (IPYR_MYCTU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IPYR
Protein name
RecName: Full=Inorganic pyrophosphatase;
EC=3.6.1.1;
AltName: Full=Pyrophosphate phospho-hydrolase;
Short=PPase;
Gene name
ppa

Comments [?]

Function Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Catalytic activity Diphosphate + H(2)O = 2 phosphate.
Cofactor Mg(2+)
Subunit Homohexamer.
Subcellular location Cytoplasm.
Similarity Belongs to the PPase family.

Keywords [?]

Cytoplasm
Hydrolase
Magnesium
Metal-binding

Gene Ontology [?]

GO:0004427; Molecular function: inorganic diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00719; Pyrophosphatase; 1;
PROSITE PS00387; PPASE; 1;

Features [?]

case <OC:Actinobacteria>
From: IPYR_MYCTU (P9WI55)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     89     89       Proton acceptor     D  
METAL     8     8       Magnesium 2     E  
METAL     52     52       Magnesium 1     D  
METAL     57     57       Magnesium 1     D  
METAL     57     57       Magnesium 2     D  
METAL     84     84       Magnesium 3     D  
METAL     89     89       Magnesium 1     D  
METAL     89     89       Magnesium 3     D  
end case
BINDING     16     16       Substrate     K  
BINDING     30     30       Substrate     R  
BINDING     42     42       Substrate     Y  
BINDING     126     126       Substrate     Y  
case not <OC:Actinobacteria>
From: IPYR_ECOLI (P0A7A9)
METAL     66     66       Magnesium 1     D  
METAL     71     71       Magnesium 1     D  
METAL     71     71       Magnesium 2     D  
METAL     103     103       Magnesium 1     D  
end case

Additional information [?]

Size range 158-215 amino acids
Related rules None
Fusion None


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