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| Annotation rule MF_00209 |
General rule information
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| Accession | MF_00209 |
| Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 32) |
| Name | Inorganic_PPase |
| Scope | Bacteria
Archaea |
| Templates | P0A7A9 (IPYR_ECOLI); P38576 (IPYR_THET8); P50308 (IPYR_SULAC); P80562 (IPYR_NOSS1); P9WI55 (IPYR_MYCTU): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. |
| Catalytic activity | RHEA:24576: diphosphate + H2O = H(+) + 2 phosphate
EC 3.6.1.1 |
| Cofactor | Mg(2+) |
| Subunit | Homohexamer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the PPase family. |
Keywords
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Gene Ontology
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GO:0004427; Molecular function: inorganic diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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case <OC:Actinobacteria>
| From: IPYR_MYCTU (P9WI55) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 89 | 89 | Proton acceptor | D | ||||||||
| METAL | 8 | 8 | Magnesium 2 | E | ||||||||
| METAL | 52 | 52 | Magnesium 1 | D | ||||||||
| METAL | 57 | 57 | Magnesium 1 | D | ||||||||
| METAL | 57 | 57 | Magnesium 2 | D | ||||||||
| METAL | 84 | 84 | Magnesium 3 | D | ||||||||
| METAL | 89 | 89 | Magnesium 1 | D | ||||||||
| METAL | 89 | 89 | Magnesium 3 | D | ||||||||
end case
| BINDING | 16 | 16 | Substrate | K | ||||||||
| BINDING | 30 | 30 | Substrate | R | ||||||||
| BINDING | 42 | 42 | Substrate | Y | ||||||||
| BINDING | 126 | 126 | Substrate | Y |
case not <OC:Actinobacteria>
| From: IPYR_ECOLI (P0A7A9) | ||||||||||||
| METAL | 66 | 66 | Magnesium 1 | D | ||||||||
| METAL | 71 | 71 | Magnesium 1 | D | ||||||||
| METAL | 71 | 71 | Magnesium 2 | D | ||||||||
| METAL | 103 | 103 | Magnesium 1 | D | ||||||||
end case
Additional information
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| Size range | 158-215 amino acids |
| Related rules | None |
| Fusion | None |