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HAMAP rule MF_00213
General rule information
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| Accession | MF_00213 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 26) |
| Name | HypA_HybF |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A700 (HYPA_ECOLI); P0A703 (HYBF_ECOLI); P0A0U4 (HYPA_HELPY); Q5JIH3 (HYPA_THEKO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00213 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HYPA |
| Protein name | RecName: Full=Hydrogenase maturation factor HypA; |
| Gene name | Name=hypA; |
Comments
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| FUNCTION | Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. |
| SIMILARITY | Belongs to the HypA/HybF family. |
Keywords
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| Metal-binding | |
| Nickel | |
| case <FTGroup:1> | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0016151; Molecular function:nickel cation binding | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0036211; Biological process:protein modification process | |
Cross-references
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| Pfam | PF01155; HypA; 1; |
| PIRSF | PIRSF004761; Hydrgn_mat_HypA; 1; |
| NCBIfam | TIGR00100; HypA; 1; |
| PROSITE | PS01249; HYPA; 1; |
Features
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| From: HYPA_HELPY (P0A0U4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 2 | 2 | /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786" |
H | ||||||||
| BINDING | 74 | 74 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 77 | 77 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
[CH] | 1 | |||||||
| BINDING | 91 | 91 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 94 | 94 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 105-160 amino acids |
| Related rules |
MF_02099 |
| Fusion | Nter: None Cter: None |
| Comments | Some species such as E.coli have a HypA homolog, named HybF (see MF_02099). |