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HAMAP rule MF_00213

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General rule information [?]

Accession MF_00213
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 26)
Name HypA_HybF
Scope(s) Bacteria
Archaea
Template(s) P0A700 (HYPA_ECOLI); P0A703 (HYBF_ECOLI); P0A0U4 (HYPA_HELPY); Q5JIH3 (HYPA_THEKO); [ Recover all ]
Triggered by HAMAP; MF_00213 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HYPA
Protein name RecName: Full=Hydrogenase maturation factor HypA;
Gene name Name=hypA;

Comments [?]

FUNCTIONInvolved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
SIMILARITYBelongs to the HypA/HybF family.

Keywords [?]

Metal-binding
Nickel
case <FTGroup:1>
Zinc
end case

Gene Ontology [?]

GO:0016151; Molecular function:nickel cation binding
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0036211; Biological process:protein modification process

Cross-references [?]

Pfam PF01155; HypA; 1;
PIRSF PIRSF004761; Hydrgn_mat_HypA; 1;
NCBIfam TIGR00100; HypA; 1;
PROSITE PS01249; HYPA; 1;

Features [?]

From: HYPA_HELPY (P0A0U4)
Key From To Description Tag Condition FTGroup
BINDING 2 2 /ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"
H
BINDING 74 74 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 77 77 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
[CH] 1
BINDING 91 91 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 94 94 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1

Additional information [?]

Size range 105-160 amino acids
Related rules MF_02099
Fusion Nter: None Cter: None
Comments Some species such as E.coli have a HypA homolog, named HybF (see MF_02099).



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