HAMAP rule MF_00218
General rule information
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Accession | MF_00218 |
Dates | 1-JUN-2001 (Created) 14-MAY-2022 (Last updated, Version 36) |
Name | URO_D |
Scope | Bacteria
Archaea |
Templates | P32395 (DCUP_BACSU); P32920 (DCUP_CERS4); P06132 (DCUP_HUMAN): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. |
Catalytic activity | RHEA:19865: 4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III
EC 4.1.1.37 |
Pathway | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the uroporphyrinogen decarboxylase family. |
Keywords
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Gene Ontology
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GO:0004853; Molecular function: uroporphyrinogen decarboxylase activity.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS00906; UROD_1; 1; |
PS00907; UROD_2; 1; | |
Pfam | PF01208; URO-D; 1; |
TIGRFAMs | TIGR01464; HemE; 1; |
Features
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From: DCUP_BACSU (P32395) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 29 | 33 | /ligand="substrate | R-x-[AVS]-x-R | ||||||||
BINDING (Optional) | 48 | 48 | /ligand="substrate | F | ||||||||
BINDING | 78 | 78 | /ligand="substrate | D | ||||||||
BINDING | 154 | 154 | /ligand="substrate | Y | ||||||||
BINDING | 209 | 209 | /ligand="substrate | [ST] | ||||||||
BINDING | 322 | 322 | /ligand="substrate | H | ||||||||
SITE | 78 | 78 | Transition state stabilizer | D |
Additional information
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Size range | 324-385 amino acids |
Related rules | None |
Fusion | None |