HAMAP rule MF_00218

General rule information [?]

Accession	MF_00218
Dates	1-JUN-2001 (Created) 14-MAY-2022 (Last updated, Version 36)

Name

URO_D

Scope

Bacteria

Archaea

Templates

P32395 (DCUP_BACSU); P32920 (DCUP_CERS4); P06132 (DCUP_HUMAN): [Recover all]

Triggered by

HAMAP; MF_00218 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DCUP

Protein name

RecName:		Full=Uroporphyrinogen decarboxylase;
		Short=UPD;
		Short=URO-D;
		EC 4.1.1.37;

Gene name

hemE

Comments [?]

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Catalytic activity	RHEA:19865: 4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III EC 4.1.1.37
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the uroporphyrinogen decarboxylase family.

Keywords [?]

Cytoplasm
Lyase
Decarboxylase
Porphyrin biosynthesis

Gene Ontology [?]

GO:0004853; Molecular function: uroporphyrinogen decarboxylase activity.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS00906; UROD_1; 1;
	PS00907; UROD_2; 1;
Pfam	PF01208; URO-D; 1;
TIGRFAMs	TIGR01464; HemE; 1;

Features [?]

From: DCUP_BACSU (P32395)

Key From To Description Tag Condition FTGroup

BINDING 29 33 /ligand="substrate R-x-[AVS]-x-R

BINDING (Optional) 48 48 /ligand="substrate F

BINDING 78 78 /ligand="substrate D

BINDING 154 154 /ligand="substrate Y

BINDING 209 209 /ligand="substrate [ST]

BINDING 322 322 /ligand="substrate H

SITE 78 78 Transition state stabilizer D

Additional information [?]

Size range	324-385 amino acids
Related rules	None
Fusion	None

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