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HAMAP rule MF_00218

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General rule information [?]

Accession MF_00218
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 37)
Name URO_D
Scope(s) Bacteria
Template(s) P32395 (DCUP_BACSU); P32920 (DCUP_CERS4); P06132 (DCUP_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_00218 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DCUP
Protein name RecName: Full=Uroporphyrinogen decarboxylase;
Gene name Name=hemE;

Comments [?]

FUNCTIONCatalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
CATALYTIC ACTIVITY Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=;
PATHWAYPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
SIMILARITYBelongs to the uroporphyrinogen decarboxylase family.

Keywords [?]

Gene Ontology [?]

GO:0004853; Molecular function:uroporphyrinogen decarboxylase activity
GO:0006779; Biological process:porphyrin-containing compound biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00906; UROD_1; 1;
PROSITE PS00907; UROD_2; 1;
Pfam PF01208; URO-D; 1;
NCBIfam TIGR01464; HemE; 1;

Features [?]

From: DCUP_BACSU (P32395)
Key From To Description Tag Condition FTGroup
BINDING 29 33 /ligand="substrate" R-x-[AVS]-x-R
BINDING 48 48 /ligand="substrate" F
BINDING 78 78 /ligand="substrate" D
BINDING 154 154 /ligand="substrate" Y
BINDING 209 209 /ligand="substrate" [ST]
BINDING 322 322 /ligand="substrate" H
SITE 78 78 /note="Transition state stabilizer" D

Additional information [?]

Size range 324-385 amino acids
Related rules None
Fusion Nter: None Cter: None

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