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Annotation rule MF_00218
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General rule information [?]

Accession MF_00218
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 34)
Name URO_D
Scope
Bacteria
Archaea
Templates P32395 (DCUP_BACSU); P32920 (DCUP_RHOS4); P06132 (DCUP_HUMAN): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DCUP
Protein name
RecName: Full=Uroporphyrinogen decarboxylase;
Short=UPD;
Short=URO-D;
EC 4.1.1.37;
Gene name
hemE

Comments [?]

Function Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Catalytic activity RHEA:19865: 4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III
EC 4.1.1.37
Pathway Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the uroporphyrinogen decarboxylase family.

Keywords [?]


Gene Ontology [?]

GO:0004853; Molecular function: uroporphyrinogen decarboxylase activity.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00906; UROD_1; 1;
PS00907; UROD_2; 1;
Pfam PF01208; URO-D; 1;
TIGRFAMs TIGR01464; HemE; 1;

Features [?]

From: DCUP_BACSU (P32395)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     29     33       Substrate binding     R-x-[AVS]-x-R  
BINDING (Optional)     48     48       Substrate     F  
BINDING     78     78       Substrate     D  
BINDING     154     154       Substrate     Y  
BINDING     209     209       Substrate     [ST]  
BINDING     322     322       Substrate     H  
SITE     78     78       Transition state stabilizer     D  

Additional information [?]

Size range 324-385 amino acids
Related rules None
Fusion None