![]() |
|
Annotation rule MF_00220 |
Accession | MF_00220 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 37) |
Name | PyrC_classI |
Scope | Bacteria
Archaea |
Templates | Q81WF0 (PYRC_BACAN); Q5SK67 (PYRC_THET8); O66990 (PYRC_AQUAE); Q5HGN1 (PYRC_STAAC): [Recover all] |
Triggered by |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. |
Catalytic activity | RHEA:24296: (S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate
EC 3.5.2.3 |
Cofactor | Zn(2+) Note: Binds 2 Zn(2+) ions per subunit. |
Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. |
Similarity | Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. |
Pfam | PF01979; Amidohydro_1; 1; |
TIGRFAMs | TIGR00857; PyrC_multi; 1; |
PROSITE | PS00482; DIHYDROOROTASE_1; 1; |
PS00483; DIHYDROOROTASE_2; 1; |
From: PYRC_BACAN (Q81WF0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 61 | 63 | Substrate binding | H-x-R | ||||||||
REGION | 322 | 323 | Substrate binding | [FP]-G | ||||||||
ACT_SITE | 304 | 304 | D | |||||||||
METAL | 59 | 59 | Zinc 1; via tele nitrogen | H | ||||||||
METAL | 61 | 61 | Zinc 1; via tele nitrogen | H | ||||||||
METAL | 151 | 151 | Zinc 1 | D | ||||||||
METAL | 151 | 151 | Zinc 2 | D | ||||||||
METAL | 178 | 178 | Zinc 2; via pros nitrogen | H | ||||||||
METAL | 231 | 231 | Zinc 2; via tele nitrogen | H | ||||||||
METAL | 304 | 304 | Zinc 1 | D | ||||||||
BINDING | 93 | 93 | Substrate | N | ||||||||
BINDING | 277 | 277 | Substrate; via amide nitrogen and carbonyl oxygen | N | ||||||||
BINDING | 308 | 308 | Substrate | H |
From: PYRC_PYRAB (Q9UXV6) | ||||||||||||
REGION (Optional) | 59 | 61 | Substrate binding | H-x-R | ||||||||
REGION (Optional) | 286 | 287 | Substrate binding | [FPA]-G | ||||||||
ACT_SITE | 272 | 272 | D | |||||||||
METAL | 57 | 57 | Zinc 1; via tele nitrogen | H | ||||||||
METAL | 59 | 59 | Zinc 1; via tele nitrogen | H | ||||||||
METAL | 135 | 135 | Zinc 1 | [KE] | ||||||||
METAL | 135 | 135 | Zinc 2 | [KE] | ||||||||
METAL | 164 | 164 | Zinc 2; via pros nitrogen | H | ||||||||
METAL | 204 | 204 | Zinc 2; via tele nitrogen | H | ||||||||
METAL | 272 | 272 | Zinc 1 | D | ||||||||
MOD_RES (Optional) | 135 | 135 | N6-carboxylysine | K | ||||||||
BINDING (Optional) | 91 | 91 | Substrate | N | ||||||||
BINDING (Optional) | 276 | 276 | Substrate | H |
Size range | 370-500 amino acids |
Size range | 380-480 amino acids |
Related rules | MF_00219 (PYRC) |
Fusion | None |
Comments | Classification into subfamilies was done according to PubMed:24332717. |