HAMAP rule MF_00225
General rule information
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Accession | MF_00225 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 42) |
Name | DHO_dh_type2 |
Scope | Archaea; Halobacteriales
Bacteria |
Template | P0A7E1 (PYRD_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. |
Catalytic activity | RHEA:30187: (S)-dihydroorotate + a quinone = a quinol + orotate
EC 1.3.5.2 |
Cofactor | FMN Note: Binds 1 FMN per subunit. |
Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. |
Subunit | Monomer. |
Subcellular location | Cell membrane; Peripheral membrane protein. |
Similarity | Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0004152; Molecular function: dihydroorotate dehydrogenase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Pfam | PF01180; DHO_dh; 1; |
PIRSF | PIRSF000164; DHO_oxidase; 1; |
TIGRFAMs | TIGR01036; PyrD_sub2; 1; |
PROSITE | PS00911; DHODEHASE_1; 1; |
PS00912; DHODEHASE_2; 1; |
Features
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From: PYRD_ECOLI (P0A7E1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 62 | 66 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | [AP]-x-x-x-K | ||||||||
BINDING | 318 | 319 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | [YF]-[ST] | ||||||||
BINDING | 111 | 115 | /ligand="substrate | N-x-[MYLFN]-G-[FL] | ||||||||
BINDING | 246 | 247 | /ligand="substrate | N-T | ||||||||
ACT_SITE | 175 | 175 | Nucleophile | [SC] | ||||||||
BINDING | 66 | 66 | /ligand="substrate | K | ||||||||
BINDING | 86 | 86 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | [TASG] | ||||||||
BINDING | 139 | 139 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | [NS] | ||||||||
BINDING | 172 | 172 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | N | ||||||||
BINDING | 172 | 172 | /ligand="substrate | N | ||||||||
BINDING | 177 | 177 | /ligand="substrate | N | ||||||||
BINDING | 217 | 217 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | K | ||||||||
BINDING | 245 | 245 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | [TASGV] | ||||||||
BINDING | 268 | 268 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | G | ||||||||
BINDING | 297 | 297 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | G |
Additional information
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Size range | 333-396 amino acids |
Related rules | MF_00224 (PYRD) |
Fusion | None |