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HAMAP rule MF_00227

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General rule information [?]

Accession MF_00227
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 22)
Name RNase_P
Scope(s) Bacteria
Template(s) P25814 (RNPA_BACSU); P0A0H5 (RNPA_STAAU); [ Recover all ]
Triggered by HAMAP; MF_00227 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RNPA
Protein name RecName: Full=Ribonuclease P protein component;
                 Short=RNase P protein;
                 Short=RNaseP protein;
AltName: Full=Protein C5;
Gene name Name=rnpA;

Comments [?]

FUNCTIONRNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.; EC=;
SUBUNITConsists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
SIMILARITYBelongs to the RnpA family.

Keywords [?]

Gene Ontology [?]

GO:0004526; Molecular function:ribonuclease P activity
GO:0000049; Molecular function:tRNA binding
GO:0001682; Biological process:tRNA 5'-leader removal

Cross-references [?]

Pfam PF00825; Ribonuclease_P; 1;
NCBIfam TIGR00188; RnpA; 1;

Features [?]

Additional information [?]

Size range 108-166 amino acids
Related rules None
Fusion Nter: None Cter: None

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