HAMAP rule MF_00227

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00227
Accession	MF_00227
Dates	28-FEB-2005 (Created) 01-JUN-2023 (Last updated, Version 15)
Name	RNase_P
Scope(s)	Bacteria
Template(s)	P25814; P0A0H5; [ Recover all ]
Triggered by	HAMAP; MF_00227 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RNPA
Protein name	RecName: Full=Ribonuclease P protein component; Short=RNase P protein; Short=RNaseP protein; EC=3.1.26.5; AltName: Full=Protein C5;
Gene name	Name=rnpA;

Comments [?]

FUNCTION	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
CATALYTIC ACTIVITY	Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.; EC=3.1.26.5;
SUBUNIT	Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
SIMILARITY	Belongs to the RnpA family.

Keywords [?]

Gene Ontology [?]

GO:0004526; Molecular function:ribonuclease P activity

GO:0000049; Molecular function:tRNA binding

GO:0001682; Biological process:tRNA 5'-leader removal

Cross-references [?]

Features [?]

Additional information [?]