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Annotation rule MF_00227
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General rule information [?]

Accession MF_00227
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 21)
Name RNase_P
Scope
Bacteria
Templates P25814 (RNPA_BACSU); P0A0H5 (RNPA_STAAU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RNPA
Protein name
RecName: Full=Ribonuclease P protein component;
Short=RNase P protein;
Short=RNaseP protein;
EC 3.1.26.5;
AltName: Full=Protein C5;
Gene name
rnpA

Comments [?]

Function RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Catalytic activity Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.; EC=3.1.26.5;
Subunit Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
Similarity Belongs to the RnpA family.

Keywords [?]


Gene Ontology [?]

GO:0004526; Molecular function: ribonuclease P activity.
GO:0000049; Molecular function: tRNA binding.
GO:0001682; Biological process: tRNA 5'-leader removal.

Cross-references [?]

Pfam PF00825; Ribonuclease_P; 1;
TIGRFAMs TIGR00188; RnpA; 1;
PROSITE PS00648; RIBONUCLEASE_P; 1;

Additional information [?]

Size range 108-166 amino acids
Related rules None
Fusion None