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HAMAP rule MF_00228

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General rule information [?]

Accession MF_00228
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 44)
Name Thz_kinase
Scope(s) Bacteria
Template(s) P39593 (THIM_BACSU); [ Recover all ]
Triggered by HAMAP; MF_00228 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier THIM
Protein name RecName: Full=Hydroxyethylthiazole kinase;
AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase;
                 Short=TH kinase;
                 Short=Thz kinase;
Gene name Name=thiM;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ).
CATALYTIC ACTIVITY Reaction=5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2- phosphooxyethyl)-thiazole + ADP + H(+); Xref=Rhea:RHEA:24212, ChEBI:CHEBI:15378, ChEBI:CHEBI:17957, ChEBI:CHEBI:30616, ChEBI:CHEBI:58296, ChEBI:CHEBI:456216; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYCofactor biosynthesis; thiamine diphosphate biosynthesis; 4- methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4- methylthiazole: step 1/1.
SIMILARITYBelongs to the Thz kinase family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0005524; Molecular function:ATP binding
GO:0004417; Molecular function:hydroxyethylthiazole kinase activity

Cross-references [?]

Pfam PF02110; HK; 1;
NCBIfam TIGR00694; ThiM; 1;

Features [?]

From: THIM_BACSU (P39593)
Key From To Description Tag Condition FTGroup
BINDING 45 45 /ligand="substrate" M
BINDING 121 121 /ligand="ATP"
BINDING 168 168 /ligand="ATP"
BINDING 195 195 /ligand="substrate" [GA]

Additional information [?]

Size range 220-320 amino acids
Related rules None
Fusion Nter: None Cter: MF_00097 (thiE)
Comments AGRFC has internal deletion; not shown in alignment or used in size range. Fusion with thiE in SYMTH.

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