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Annotation rule MF_00228
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General rule information [?]

Accession MF_00228
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 40)
Name Thz_kinase
Scope
Bacteria
Archaea
Template P39593 (THIM_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
THIM
Protein name
RecName: Full=Hydroxyethylthiazole kinase;
EC 2.7.1.50;
AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase;
Short=TH kinase;
Short=Thz kinase;
Gene name
thiM

Comments [?]

Function Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
Catalytic activity RHEA:24212: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)
EC 2.7.1.50
Cofactor Mg(2+)
Pathway Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.
Similarity Belongs to the Thz kinase family.

Keywords [?]

Magnesium
Metal-binding
Thiamine biosynthesis
Transferase
Kinase
ATP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0004417; Molecular function: hydroxyethylthiazole kinase activity.

Cross-references [?]

Pfam PF02110; HK; 1;
PRINTS PR01099; HYETHTZKNASE; 1;
TIGRFAMs TIGR00694; ThiM; 1;

Features [?]

From: THIM_BACSU (P39593)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     45     45       Substrate; via amide nitrogen     M  
BINDING     121     121       ATP        
BINDING     168     168       ATP     [ST]  
BINDING     195     195       Substrate; via amide nitrogen     [GA]  

Additional information [?]

Size range 220-320 amino acids
Related rules None
Fusion Nter: None; Cter: MF_00097 (thiE)
Comments AGRFC has internal deletion; not shown in alignment or used in size range. Fusion with thiE in SYMTH.


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