HAMAP rule MF_00228

General rule information [?]

Accession	MF_00228
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 43)
Name	Thz_kinase
Scope(s)	Bacteria Archaea
Template(s)	P39593 (THIM_BACSU); [ Recover all ]
Triggered by	HAMAP; MF_00228 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	THIM
Protein name	RecName: Full=Hydroxyethylthiazole kinase; EC=2.7.1.50; AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase; Short=TH kinase; Short=Thz kinase;
Gene name	Name=thiM;

Comments [?]

FUNCTION	Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ).
CATALYTIC ACTIVITY	Reaction=5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2- phosphooxyethyl)-thiazole + ADP + H(+); Xref=Rhea:RHEA:24212, ChEBI:CHEBI:15378, ChEBI:CHEBI:17957, ChEBI:CHEBI:30616, ChEBI:CHEBI:58296, ChEBI:CHEBI:456216; EC=2.7.1.50;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAY	Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4- methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4- methylthiazole: step 1/1.
SIMILARITY	Belongs to the Thz kinase family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding

GO:0005524; Molecular function:ATP binding

GO:0004417; Molecular function:hydroxyethylthiazole kinase activity

Cross-references [?]

Features [?]

From: THIM_BACSU (P39593)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="substrate"

BINDING

121

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

BINDING

168

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

[ST]

BINDING

195

/ligand="substrate"

[GA]

Additional information [?]

Size range	220-320 amino acids
Related rules	None
Fusion	Nter: None Cter: MF_00097 (thiE)
Comments	AGRFC has internal deletion; not shown in alignment or used in size range. Fusion with thiE in SYMTH.