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Annotation rule MF_00228 |
Accession | MF_00228 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 40) |
Name | Thz_kinase |
Scope | Bacteria
Archaea |
Template | P39593 (THIM_BACSU) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). |
Catalytic activity | RHEA:24212: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)
EC 2.7.1.50 |
Cofactor | Mg(2+) |
Pathway | Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. |
Similarity | Belongs to the Thz kinase family. |
From: THIM_BACSU (P39593) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 45 | 45 | Substrate; via amide nitrogen | M | ||||||||
BINDING | 121 | 121 | ATP | |||||||||
BINDING | 168 | 168 | ATP | [ST] | ||||||||
BINDING | 195 | 195 | Substrate; via amide nitrogen | [GA] |
Size range | 220-320 amino acids |
Related rules | None |
Fusion | Nter: None; Cter: MF_00097 (thiE) |
Comments | AGRFC has internal deletion; not shown in alignment or used in size range. Fusion with thiE in SYMTH. |