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| Annotation rule MF_00241 |
General rule information
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| Accession | MF_00241 |
| Dates | 1-JUN-2001 (Created) 12-DEC-2019 (Last updated, Version 22) |
| Name | Ogg |
| Scope | Bacteria
Archaea |
| Templates | Q58134 (OGG1_METJA); O29876 (OGG1_ARCFU); Q97CP1 (OGG1_THEVO); Q97ZK2 (OGG1_SACS2): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). |
| Catalytic activity | Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.; EC=4.2.99.18; |
| Similarity | Belongs to the type-2 OGG1 family. |
Keywords
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Gene Ontology
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GO:0003906; Molecular function: DNA-(apurinic or apyrimidinic site) endonuclease activity.
GO:0016799; Molecular function: hydrolase activity, hydrolyzing N-glycosyl compounds.
GO:0006284; Biological process: base-excision repair.
GO:0016799; Molecular function: hydrolase activity, hydrolyzing N-glycosyl compounds.
GO:0006284; Biological process: base-excision repair.
Cross-references
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| PIRSF | PIRSF005954; Thrmst_ogg; 1; |
Features
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| From: OGG1_METJA (Q58134) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 129 | 129 | K | |||||||||
| ACT_SITE | 147 | 147 | D | |||||||||
| SITE | Cter | Cter | Important for guanine/8-oxoguanine distinction | K | ||||||||
Additional information
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| Size range | 170-270 amino acids |
| Related rules | None |
| Fusion | None |