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HAMAP rule MF_00241

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General rule information [?]

Accession MF_00241
Dates 1-JUN-2001 (Created)
30-JAN-2024 (Last updated, Version 25)
Name Ogg
Scope(s) Bacteria
Template(s) Q58134 (OGG1_METJA); O29876 (OGG1_ARCFU); Q97CP1 (OGG1_THEVO); Q97ZK2 (OGG1_SACS2); [ Recover all ]
Triggered by HAMAP; MF_00241 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier OGG1
Protein name RecName: Full=8-oxoguanine DNA glycosylase/AP lyase;
RecName: Full=8-oxoguanine DNA glycosylase;
                 Short=8-oxoG DNA glycosylase;
RecName: Full=DNA-(apurinic or apyrimidinic site) lyase;
                 Short=AP lyase;
Gene name Name=ogg;

Comments [?]

FUNCTIONCatalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).
CATALYTIC ACTIVITY Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'- deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=;
SIMILARITYBelongs to the type-2 OGG1 family.

Keywords [?]

Gene Ontology [?]

GO:0003906; Molecular function:DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0016799; Molecular function:hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0006284; Biological process:base-excision repair

Cross-references [?]

PIRSF PIRSF005954; Thrmst_ogg; 1;

Features [?]

From: OGG1_METJA (Q58134)
Key From To Description Tag Condition FTGroup
ACT_SITE 129 129 K
ACT_SITE 147 147 D
SITE Cter Cter /note="Important for guanine/8-oxoguanine distinction" K

Additional information [?]

Size range 170-270 amino acids
Related rules None
Fusion Nter: None Cter: None

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