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Annotation rule MF_00241
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General rule information [?]

Accession MF_00241
Dates 1-JUN-2001 (Created)
8-JUN-2021 (Last updated, Version 24)
Name Ogg
Scope
Bacteria
Archaea
Templates Q58134 (OGG1_METJA); O29876 (OGG1_ARCFU); Q97CP1 (OGG1_THEVO); Q97ZK2 (OGG1_SACS2): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
OGG1
Protein name
RecName: Full=8-oxoguanine DNA glycosylase/AP lyase;
Includes:
RecName: Full=8-oxoguanine DNA glycosylase;
Short=8-oxoG DNA glycosylase;
EC 3.2.2.-;
Includes:
RecName: Full=DNA-(apurinic or apyrimidinic site) lyase;
Short=AP lyase;
EC 4.2.99.18;
Gene name
ogg

Comments [?]

Function Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).
Catalytic activity RHEA:66592: 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)
EC 4.2.99.18
Similarity Belongs to the type-2 OGG1 family.

Keywords [?]

DNA damage
DNA repair
Glycosidase
Hydrolase
Lyase
Multifunctional enzyme

Gene Ontology [?]

GO:0003906; Molecular function: DNA-(apurinic or apyrimidinic site) endonuclease activity.
GO:0016799; Molecular function: hydrolase activity, hydrolyzing N-glycosyl compounds.
GO:0006284; Biological process: base-excision repair.

Cross-references [?]

PIRSF PIRSF005954; Thrmst_ogg; 1;

Features [?]

From: OGG1_METJA (Q58134)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     129     129             K  
ACT_SITE     147     147             D  
SITE     Cter     Cter       Important for guanine/8-oxoguanine distinction     K  

Additional information [?]

Size range 170-270 amino acids
Related rules None
Fusion None


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