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Annotation rule MF_00241 |
Accession | MF_00241 |
Dates | 1-JUN-2001 (Created) 8-JUN-2021 (Last updated, Version 24) |
Name | Ogg |
Scope | Bacteria
Archaea |
Templates | Q58134 (OGG1_METJA); O29876 (OGG1_ARCFU); Q97CP1 (OGG1_THEVO); Q97ZK2 (OGG1_SACS2): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). |
Catalytic activity | RHEA:66592: 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)
EC 4.2.99.18 |
Similarity | Belongs to the type-2 OGG1 family. |
PIRSF | PIRSF005954; Thrmst_ogg; 1; |
From: OGG1_METJA (Q58134) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 129 | 129 | K | |||||||||
ACT_SITE | 147 | 147 | D | |||||||||
SITE | Cter | Cter | Important for guanine/8-oxoguanine distinction | K |
Size range | 170-270 amino acids |
Related rules | None |
Fusion | None |