HAMAP rule MF_00241
General rule information
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| Accession | MF_00241 |
| Dates | 1-JUN-2001 (Created)
30-JAN-2024 (Last updated, Version 25) |
| Name | Ogg |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q58134 (OGG1_METJA); O29876 (OGG1_ARCFU); Q97CP1 (OGG1_THEVO); Q97ZK2 (OGG1_SACS2); [ Recover all ] |
| Triggered by |
HAMAP; MF_00241 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | OGG1 |
| Protein name | RecName: Full=8-oxoguanine DNA glycosylase/AP lyase; Includes: RecName: Full=8-oxoguanine DNA glycosylase; Short=8-oxoG DNA glycosylase; EC=3.2.2.-; Includes: RecName: Full=DNA-(apurinic or apyrimidinic site) lyase; Short=AP lyase; EC=4.2.99.18; |
| Gene name | Name=ogg; |
Comments
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| FUNCTION | Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). |
| CATALYTIC ACTIVITY | Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'- deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; |
| SIMILARITY | Belongs to the type-2 OGG1 family. |
Keywords
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Gene Ontology
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| GO:0003906; Molecular function:DNA-(apurinic or apyrimidinic site) endonuclease activity |
| GO:0016799; Molecular function:hydrolase activity, hydrolyzing N-glycosyl compounds |
| GO:0006284; Biological process:base-excision repair |
Cross-references
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| PIRSF | PIRSF005954; Thrmst_ogg; 1; |
Features
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| From: OGG1_METJA (Q58134) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 129 | 129 | K | |||||||||
| ACT_SITE | 147 | 147 | D | |||||||||
| SITE | Cter | Cter | /note="Important for guanine/8-oxoguanine distinction" | K | ||||||||
Additional information
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| Size range | 170-270 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |