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| Annotation rule MF_00253 |
General rule information
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| Accession | MF_00253 |
| Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 27) |
| Name | Gly_tRNA_synth |
| Scope | Bacteria
Archaea |
| Template | P56206 (SYG_THET8) |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
|
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case <OC:Bacteria>
| Gene name |
|
end case
case <OC:Archaea>
| Gene name |
|
end case
Comments
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| Function | Catalyzes the attachment of glycine to tRNA(Gly). |
| Catalytic activity | RHEA:16013: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
EC 6.1.1.14 |
case <OC:Bacteria>
| Subunit | Homodimer. |
end case
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the class-II aminoacyl-tRNA synthetase family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0004820; Molecular function: glycine-tRNA ligase activity.
GO:0006426; Biological process: glycyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0004820; Molecular function: glycine-tRNA ligase activity.
GO:0006426; Biological process: glycyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00587; tRNA-synt_2b; 1; |
| PRINTS | PR01043; TRNASYNTHGLY; 1; |
| TIGRFAMs | TIGR00389; GlyS_dimeric; 1; |
| PROSITE | PS50862; AA_TRNA_LIGASE_II; 1; |
Features
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case <OC:Bacteria>
| From: SYG_THET8 (P56206) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 221 | 223 | ATP | R-N-E | ||||||||
| NP_BIND | 231 | 236 | ATP | [FILV]-R-x(3)-[FL] | ||||||||
| NP_BIND | 305 | 306 | ATP | E-[CILV] | ||||||||
| NP_BIND | 364 | 367 | ATP | G-x(2)-R | ||||||||
| REGION | 236 | 240 | Substrate binding | [FL]-x-Q-x-E | ||||||||
| REGION | 360 | 364 | Substrate binding | E-x(3)-G | ||||||||
| BINDING | 99 | 99 | Substrate | [KR] | ||||||||
| BINDING | 189 | 189 | Substrate | E | ||||||||
end case
case <OC:Archaea>
| From: SYG_METJA (Q57681) | ||||||||||||
| NP_BIND | 196 | 198 | ATP | R-N-E | ||||||||
| NP_BIND | 206 | 211 | ATP | [FILV]-R-x(3)-F | ||||||||
| NP_BIND | 328 | 329 | ATP | E-[CILV] | ||||||||
| NP_BIND | 451 | 454 | ATP | G-x(2)-R | ||||||||
| REGION | 211 | 215 | Substrate binding | F-x(3)-E | ||||||||
| REGION | 447 | 451 | Substrate binding | E-x(3)-G | ||||||||
| BINDING | 98 | 98 | Substrate | R | ||||||||
| BINDING | 164 | 164 | Substrate | E | ||||||||
end case
Additional information
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case <OC:Bacteria>
| Size range | 445-506 amino acids |
end case
case <OC:Archaea>
| Size range | 565-583 amino acids |
end case
| Related rules | None |
| Fusion | None |