HAMAP rule MF_00253

General rule information [?]

Accession	MF_00253
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 31)

Name	Gly_tRNA_synth

Scope

Bacteria

Archaea

Template

P56206 (SYG_THET8)

case <OC:Bacteria>

Triggered by

HAMAP; MF_00253_B (Get profile general information and statistics)

end case

case <OC:Archaea>

Triggered by

HAMAP; MF_00253_A (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SYG

Protein name

RecName:		Full=Glycine--tRNA ligase;
		EC 6.1.1.14;
AltName:		Full=Glycyl-tRNA synthetase;
		Short=GlyRS;

case <OC:Bacteria>

Gene name

glyQS

end case

case <OC:Archaea>

Gene name

glyS

end case

Comments [?]

Function	Catalyzes the attachment of glycine to tRNA(Gly).
Catalytic activity	RHEA:16013: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly) EC 6.1.1.14

case <OC:Bacteria>

Subunit

Homodimer.

end case

Subcellular location	Cytoplasm.
Similarity	Belongs to the class-II aminoacyl-tRNA synthetase family.

Keywords [?]

Cytoplasm
Aminoacyl-tRNA synthetase
Protein biosynthesis
Ligase
ATP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004820; Molecular function: glycine-tRNA ligase activity.
GO:0006426; Biological process: glycyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00587; tRNA-synt_2b; 1;
PRINTS	PR01043; TRNASYNTHGLY; 1;
NCBIfam	TIGR00389; GlyS_dimeric; 1;
PROSITE	PS50862; AA_TRNA_LIGASE_II; 1;

Features [?]

case <OC:Bacteria>

From: SYG_THET8 (P56206)

Key From To Description Tag Condition FTGroup

BINDING 221 223 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R-N-E

BINDING 231 236 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [FILV]-R-x(3)-[FL]

BINDING 305 306 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 E-[CILV]

BINDING 364 367 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-x(2)-R

BINDING 236 240 /ligand="substrate [FL]-x-Q-x-E

BINDING 360 364 /ligand="substrate E-x(3)-G

BINDING 99 99 /ligand="substrate [KR]

BINDING 189 189 /ligand="substrate E

end case

case <OC:Archaea>

From: SYG_METJA (Q57681)

BINDING 196 198 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R-N-E

BINDING 206 211 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [FILV]-R-x(3)-F

BINDING 328 329 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 E-[CILV]

BINDING 451 454 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-x(2)-R

BINDING 211 215 /ligand="substrate F-x(3)-E

BINDING 447 451 /ligand="substrate E-x(3)-G

BINDING 98 98 /ligand="substrate R

BINDING 164 164 /ligand="substrate E

end case

Additional information [?]

case <OC:Bacteria>

Size range

445-506 amino acids

end case

case <OC:Archaea>

Size range

565-583 amino acids

end case

Related rules	None
Fusion	None

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