HAMAP rule MF_00281
General rule information
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Accession | MF_00281 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 33) |
Name | Phe_tRNA_synth_alpha1 |
Scope | Bacteria |
Templates | P08312 (SYFA_ECOLI); P27001 (SYFA_THETH): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Catalytic activity | RHEA:19413: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
EC 6.1.1.20 |
Cofactor | Mg(2+) Note: Binds 2 magnesium ions per tetramer. |
Subunit | Tetramer of two alpha and two beta subunits. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. |
Keywords
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Cytoplasm
Aminoacyl-tRNA synthetase
Protein biosynthesis
Ligase
ATP-binding
Nucleotide-binding
Magnesium
Metal-binding
Aminoacyl-tRNA synthetase
Protein biosynthesis
Ligase
ATP-binding
Nucleotide-binding
Magnesium
Metal-binding
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0004826; Molecular function: phenylalanine-tRNA ligase activity.
GO:0006432; Biological process: phenylalanyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0000287; Molecular function: magnesium ion binding.
GO:0004826; Molecular function: phenylalanine-tRNA ligase activity.
GO:0006432; Biological process: phenylalanyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: SYFA_THETH (P27001) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 262 | 262 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="shared with beta subunit | E |
Additional information
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Size range | 325-373 amino acids |
Related rules | MF_00282 (SYFA) |
Fusion | None |
Comments | BUCAI and BUCAP lack the conserved Glu that bind magnesium |