HAMAP rule MF_00288
General rule information
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| Accession | MF_00288 |
| Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 30) |
| Name | MetE |
| Scope(s) |
Archaea |
| Template(s) | P55299 (METE_METTM); [ Recover all ] |
| Triggered by |
HAMAP; MF_00288 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | METE |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| Protein name | RecName: Full=Methionine synthase; EC=2.1.1.-; AltName: Full=Homocysteine methyltransferase; AltName: Full=Methylcobalamin:homocysteine methyltransferase; |
| else | |
| Protein name | RecName: Full=Methionine synthase; EC=2.1.1.-; AltName: Full=Homocysteine methyltransferase; |
| end case | |
| Gene name | Name=metE; |
Comments
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| FUNCTION | Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. |
| else | |
| FUNCTION | Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. |
| end case | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway. |
| SIMILARITY | Belongs to the archaeal MetE family. |
Keywords
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Gene Ontology
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| GO:0008168; Molecular function:methyltransferase activity |
| GO:0009086; Biological process:methionine biosynthetic process |
Cross-references
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| Pfam | PF01717; Meth_synt_2; 1; |
Features
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| From: METE_METTM (P55299) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 201 | 201 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | ||||||||
| BINDING | 203 | 203 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
C | ||||||||
| BINDING | 224 | 224 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
E | ||||||||
| BINDING | 285 | 285 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
C | ||||||||
Additional information
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| Size range | 308-344 amino acids |
| Related rules |
MF_00172 |
| Fusion | Nter: None Cter: None |