HAMAP rule MF_00288
General rule information
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Accession | MF_00288 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 30) |
Name | MetE |
Scope | Archaea |
Template | P55299 (METE_METTM) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Protein name |
|
else
Protein name |
|
end case
Gene name |
|
Comments
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case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Function | Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. |
else
Function | Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. |
end case
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
Pathway | Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway. |
Similarity | Belongs to the archaeal MetE family. |
Keywords
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Gene Ontology
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GO:0008168; Molecular function: methyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.
GO:0009086; Biological process: methionine biosynthetic process.
Cross-references
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Pfam | PF01717; Meth_synt_2; 1; |
Features
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From: METE_METTM (P55299) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 201 | 201 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | ||||||||
BINDING | 203 | 203 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | C | ||||||||
BINDING (Optional) | 224 | 224 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | E | ||||||||
BINDING | 285 | 285 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | C |
Additional information
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Size range | 308-344 amino acids |
Related rules | MF_00172 (METE) |
Fusion | None |