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HAMAP rule MF_00288

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General rule information [?]

Accession MF_00288
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 30)
Name MetE
Scope
Archaea
Template P55299 (METE_METTM)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
METE
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Protein name
RecName: Full=Methionine synthase;
EC 2.1.1.-;
AltName: Full=Homocysteine methyltransferase;
AltName: Full=Methylcobalamin:homocysteine methyltransferase;
else
Protein name
RecName: Full=Methionine synthase;
EC 2.1.1.-;
AltName: Full=Homocysteine methyltransferase;
end case
Gene name
metE

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Function Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate.
else
Function Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.
end case
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.
Similarity Belongs to the archaeal MetE family.

Keywords [?]

Transferase
Methyltransferase
Amino-acid biosynthesis
Methionine biosynthesis
Metal-binding
Zinc

Gene Ontology [?]

GO:0008168; Molecular function: methyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.

Cross-references [?]

Pfam PF01717; Meth_synt_2; 1;

Features [?]

From: METE_METTM (P55299)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     201     201       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H  
BINDING     203     203       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     C  
BINDING (Optional)     224     224       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     E  
BINDING     285     285       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     C  

Additional information [?]

Size range 308-344 amino acids
Related rules MF_00172 (METE)
Fusion None


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