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HAMAP rule MF_00288

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General rule information [?]

Accession MF_00288
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 30)
Name MetE
Scope(s) Archaea
Template(s) P55299 (METE_METTM); [ Recover all ]
Triggered by HAMAP; MF_00288 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier METE
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Protein name RecName: Full=Methionine synthase;
                 EC=2.1.1.-;
AltName: Full=Homocysteine methyltransferase;
AltName: Full=Methylcobalamin:homocysteine methyltransferase;
else
Protein name RecName: Full=Methionine synthase;
                 EC=2.1.1.-;
AltName: Full=Homocysteine methyltransferase;
end case
Gene name Name=metE;

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
FUNCTIONCatalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate.
else
FUNCTIONCatalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.
end case
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
PATHWAYAmino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.
SIMILARITYBelongs to the archaeal MetE family.

Keywords [?]


Gene Ontology [?]

GO:0008168; Molecular function:methyltransferase activity
GO:0009086; Biological process:methionine biosynthetic process

Cross-references [?]

Pfam PF01717; Meth_synt_2; 1;

Features [?]

From: METE_METTM (P55299)
Key From To Description Tag Condition FTGroup
BINDING 201 201 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
H
BINDING 203 203 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
C
BINDING 224 224 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
E
BINDING 285 285 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
C

Additional information [?]

Size range 308-344 amino acids
Related rules MF_00172
Fusion Nter: None Cter: None



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