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Annotation rule MF_00295 |
General rule information
[?]
Accession |
MF_00295 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 33) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <FTGroup:1> and ((<FTTag:P4> and <FTTag:P7>) or <FTTag:P5a>)
Protein name |
RecName:
|
Full=Homoserine O-succinyltransferase;
|
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Short=HST;
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|
EC 2.3.1.46;
|
AltName:
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Full=Homoserine transsuccinylase;
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Short=HTS;
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|
else case <FTGroup:1> and <FTTag:P5b> and <FTTag:P10b> and not (<FTTag:P4> or <FTTag:P7>)
Protein name |
RecName:
|
Full=Homoserine O-acetyltransferase;
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Short=HAT;
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EC 2.3.1.31;
|
AltName:
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Full=Homoserine transacetylase;
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Short=HTA;
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|
else case <FTGroup:1> and <FTTag:P5b> and <FTTag:P10a> and not (<FTTag:P4> or <FTTag:P7>)
Protein name |
RecName:
|
Full=Serine O-acetyltransferase;
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Short=SAT;
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EC 2.3.1.30;
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|
else
Protein name |
RecName:
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Full=Probable acyltransferase;
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EC 2.3.1.-;
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|
end case
case <FTGroup:1> and ((<FTTag:P4> and <FTTag:P7>) or <FTTag:P5a>)
Function |
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. |
Catalytic activity |
RHEA:22008: L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine
EC 2.3.1.46
|
Pathway |
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1. |
else case <FTGroup:1> and <FTTag:P5b> and <FTTag:P10b> and not (<FTTag:P4> or <FTTag:P7>)
Function |
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. |
Catalytic activity |
RHEA:13701: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine
EC 2.3.1.31
|
Pathway |
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1. |
else case <FTGroup:1> and <FTTag:P5b> and <FTTag:P10a> and not (<FTTag:P4> or <FTTag:P7>)
Function |
Transfers an acetyl group from acetyl-CoA to L-serine, forming acetyl-L-serine. |
Catalytic activity |
RHEA:24560: acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
EC 2.3.1.30
|
Pathway |
Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2. |
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the MetA family. |
case <FTGroup:1> and ((<FTTag:P4> and <FTTag:P7>) or <FTTag:P5a>)
else case <FTGroup:1> and <FTTag:P5b> and <FTTag:P10b> and not (<FTTag:P4> or <FTTag:P7>)
else case <FTGroup:1> and <FTTag:P5b> and <FTTag:P10a> and not (<FTTag:P4> or <FTTag:P7>)
end case
case <FTGroup:1> and ((<FTTag:P4> and <FTTag:P7>) or <FTTag:P5a>)
GO:0004414; Molecular function: homoserine O-acetyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.
else case <FTGroup:1> and <FTTag:P5b> and <FTTag:P10b> and not (<FTTag:P4> or <FTTag:P7>)
GO:0008899; Molecular function: homoserine O-succinyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.
else case <FTGroup:1> and <FTTag:P5b> and <FTTag:P10a> and not (<FTTag:P4> or <FTTag:P7>)
GO:0009001; Molecular function: serine O-acetyltransferase activity.
GO:0006535; Biological process: cysteine biosynthetic process from serine.
end case
From: METAA_BACC1 (Q72X44) |
Key
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From
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To
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|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
ACT_SITE
|
|
142
|
|
142
|
|
Acyl-thioester intermediate
|
|
|
|
C
|
|
1
|
ACT_SITE
|
|
235
|
|
235
|
|
Proton acceptor
|
|
|
|
H
|
|
1
|
ACT_SITE
|
|
237
|
|
237
|
|
|
|
|
|
E
|
|
|
BINDING
|
|
163
|
|
163
|
|
Substrate
|
|
|
|
K
|
|
1
|
BINDING (Optional)
|
|
192
|
|
192
|
|
Substrate
|
|
|
|
S
|
|
|
BINDING
|
|
249
|
|
249
|
|
Substrate
|
|
|
|
R
|
|
1
|
SITE (Optional)
|
|
109
|
|
109
|
|
Important for acyl-CoA specificity
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|
P4
|
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[NE]
|
|
|
SITE (Optional)
|
|
111
|
|
111
|
|
Important for acyl-CoA specificity
|
|
P5a
|
|
[GA]
|
|
|
SITE (Optional)
|
|
111
|
|
111
|
|
Important for acyl-CoA specificity
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|
P5b
|
|
[ED]
|
|
|
SITE (Optional)
|
|
143
|
|
143
|
|
Important for acyl-CoA specificity
|
|
P7
|
|
L
|
|
|
SITE (Optional)
|
|
192
|
|
192
|
|
Important for substrate specificity
|
|
P10a
|
|
A
|
|
|
SITE (Optional)
|
|
192
|
|
192
|
|
Important for substrate specificity
|
|
P10b
|
|
S
|
|
|
Additional information
[?]
Size range |
250-385 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Classification as HST, HAT or SAT was done according to Bastard et al. (2017) (PubMed:28581482). |