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Annotation rule MF_00296
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General rule information [?]

Accession MF_00296
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 40)
Name MetX_acyltransf
Scope
Bacteria
Archaea
Templates P45131 (METXA_HAEIN); Q8F4I0 (METXA_LEPIN); O68640 (METXA_CORGL); Q9RA51 (METXA_THET2); Q6FEQ3 (METXS_ACIAD); P57714 (METXS_PSEAE); Q8P8L2 (SST_XANCP); Q8TME4 (METXA_METAC): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <FTGroup:1> and not (<FTTag:P11> or <FTTag:P17>)
Identifier
METXA
Protein name
RecName: Full=Homoserine O-acetyltransferase;
Short=HAT;
EC 2.3.1.31;
AltName: Full=Homoserine transacetylase;
Short=HTA;
Gene name
metXA
else case <FTGroup:1> and <FTTag:P17>
Identifier
METXS
Protein name
RecName: Full=Homoserine O-succinyltransferase;
Short=HST;
EC 2.3.1.46;
AltName: Full=Homoserine transsuccinylase;
Short=HTS;
Gene name
metXS
else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and <FTTag:P9>
Identifier
METXS
Protein name
RecName: Full=Homoserine O-succinyltransferase;
Short=HST;
EC 2.3.1.46;
AltName: Full=Homoserine transsuccinylase;
Short=HTS;
Gene name
metXS
else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and not <FTTag:P9>
Identifier
SST
Protein name
RecName: Full=Serine O-succinyltransferase;
Short=SST;
EC 2.3.1.-;
else
Identifier
METX
Protein name
RecName: Full=Probable acyltransferase;
EC 2.3.1.-;
end case

Comments [?]

case <FTGroup:1> and not (<FTTag:P11> or <FTTag:P17>)
Function Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Catalytic activity RHEA:13701: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine
EC 2.3.1.31
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.
else case (<FTGroup:1> and <FTTag:P17>) or (<FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and <FTTag:P9>)
Function Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
Catalytic activity RHEA:22008: L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine
EC 2.3.1.46
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1.
else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and not <FTTag:P9>
Function Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine.
Catalytic activity RHEA:52820: L-serine + succinyl-CoA = CoA + O-succinyl-L-serine
Pathway Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.
end case
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the AB hydrolase superfamily. MetX family.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
case <FTGroup:1> and not (<FTTag:P11> or <FTTag:P17>)
Methionine biosynthesis
else case (<FTGroup:1> and <FTTag:P17>) or (<FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and <FTTag:P9>)
Methionine biosynthesis
else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and not <FTTag:P9>
Cysteine biosynthesis
end case
Transferase
Acyltransferase

Gene Ontology [?]

case <FTGroup:1> and not (<FTTag:P11> or <FTTag:P17>)
GO:0004414; Molecular function: homoserine O-acetyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.
else case (<FTGroup:1> and <FTTag:P17>) or (<FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and <FTTag:P9>)
GO:0008899; Molecular function: homoserine O-succinyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.
else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and not <FTTag:P9>
GO:0016750; Molecular function: O-succinyltransferase activity.
GO:0006535; Biological process: cysteine biosynthetic process from serine.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1; trigger=Yes;
PIRSF PIRSF000443; Homoser_Ac_trans; 1;
TIGRFAMs TIGR01392; homoserO_Ac_trn; 1;
PROSITE PS51371; CBS; 0-2; trigger=PRU00703;

Features [?]

From: METXA_HAEIN (P45131)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     48     51       Important for substrate specificity   P1P4   G-[LI]-S-[PA]  
ACT_SITE     143     143       Nucleophile     S   1
ACT_SITE     304     304             D  
ACT_SITE     337     337             H   1
BINDING     212     212       Substrate     R   1
BINDING     338     338       Substrate     D   1
SITE (Optional)     144     144       Important for substrate specificity   P9   Y  
SITE (Optional)     180     180       Important for acyl-CoA specificity   P11   R  
SITE (Optional)     306     306       Important for acyl-CoA specificity   P17   R  

Additional information [?]

Size range 315-545 amino acids
Related rules None
Fusion None
Comments Classification as HST, HAT or SST was done according to Bastard et al. (2017) (PubMed:28581482).


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