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Annotation rule MF_00296 |
General rule information
[?]
Accession |
MF_00296 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 40) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <FTGroup:1> and not (<FTTag:P11> or <FTTag:P17>)
Protein name |
RecName:
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Full=Homoserine O-acetyltransferase;
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Short=HAT;
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EC 2.3.1.31;
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AltName:
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Full=Homoserine transacetylase;
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Short=HTA;
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else case <FTGroup:1> and <FTTag:P17>
Protein name |
RecName:
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Full=Homoserine O-succinyltransferase;
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Short=HST;
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EC 2.3.1.46;
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AltName:
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Full=Homoserine transsuccinylase;
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Short=HTS;
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else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and <FTTag:P9>
Protein name |
RecName:
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Full=Homoserine O-succinyltransferase;
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Short=HST;
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EC 2.3.1.46;
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AltName:
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Full=Homoserine transsuccinylase;
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Short=HTS;
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else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and not <FTTag:P9>
Protein name |
RecName:
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Full=Serine O-succinyltransferase;
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Short=SST;
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EC 2.3.1.-;
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else
Protein name |
RecName:
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Full=Probable acyltransferase;
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EC 2.3.1.-;
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end case
case <FTGroup:1> and not (<FTTag:P11> or <FTTag:P17>)
Function |
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. |
Catalytic activity |
RHEA:13701: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine
EC 2.3.1.31
|
Pathway |
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1. |
else case (<FTGroup:1> and <FTTag:P17>) or (<FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and <FTTag:P9>)
Function |
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. |
Catalytic activity |
RHEA:22008: L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine
EC 2.3.1.46
|
Pathway |
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1. |
else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and not <FTTag:P9>
Function |
Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. |
Catalytic activity |
RHEA:52820: L-serine + succinyl-CoA = CoA + O-succinyl-L-serine
|
Pathway |
Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2. |
end case
Subunit |
Homodimer. |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the AB hydrolase superfamily. MetX family. |
case <FTGroup:1> and not (<FTTag:P11> or <FTTag:P17>)
else case (<FTGroup:1> and <FTTag:P17>) or (<FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and <FTTag:P9>)
else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and not <FTTag:P9>
end case
case <FTGroup:1> and not (<FTTag:P11> or <FTTag:P17>)
GO:0004414; Molecular function: homoserine O-acetyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.
else case (<FTGroup:1> and <FTTag:P17>) or (<FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and <FTTag:P9>)
GO:0008899; Molecular function: homoserine O-succinyltransferase activity.
GO:0009086; Biological process: methionine biosynthetic process.
else case <FTGroup:1> and <FTTag:P11> and <FTTag:P1P4> and not <FTTag:P9>
GO:0016750; Molecular function: O-succinyltransferase activity.
GO:0006535; Biological process: cysteine biosynthetic process from serine.
end case
From: METXA_HAEIN (P45131) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
|
REGION (Optional)
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48
|
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51
|
|
Important for substrate specificity
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P1P4
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G-[LI]-S-[PA]
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ACT_SITE
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143
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143
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Nucleophile
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S
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1
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ACT_SITE
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304
|
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304
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|
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D
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ACT_SITE
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337
|
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337
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|
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H
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1
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BINDING
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212
|
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212
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Substrate
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|
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R
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1
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BINDING
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338
|
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338
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Substrate
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D
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1
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SITE (Optional)
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144
|
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144
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Important for substrate specificity
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P9
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Y
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SITE (Optional)
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180
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180
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Important for acyl-CoA specificity
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P11
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R
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SITE (Optional)
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306
|
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306
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Important for acyl-CoA specificity
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P17
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R
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Additional information
[?]
Size range |
315-545 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Classification as HST, HAT or SST was done according to Bastard et al. (2017) (PubMed:28581482). |