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HAMAP rule MF_00300
General rule information
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| Accession | MF_00300 |
| Dates | 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 39) |
| Name | Chorismate_synth |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P12008 (AROC_ECOLI); O66493 (AROC_AQUAE); P56122 (AROC_HELPY); P9WPY1 (AROC_MYCTU); P0A2Y6 (AROC_STRPN); Q59803 (AROC_STAAU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00300 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AROC |
| Protein name | RecName: Full=Chorismate synthase; Short=CS; EC=4.2.3.5; AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase; |
| Gene name | Name=aroC; |
Comments
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| FUNCTION | Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. |
| CATALYTIC ACTIVITY | Reaction=5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate; Xref=Rhea:RHEA:21020, ChEBI:CHEBI:29748, ChEBI:CHEBI:43474, ChEBI:CHEBI:57701; EC=4.2.3.5; |
| COFACTOR | Name=FMNH2; Xref=ChEBI:CHEBI:57618; Note=Reduced FMN (FMNH(2)).; |
| PATHWAY | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. |
| case <OC:Bacteria> | |
| SUBUNIT | Homotetramer. |
| end case | |
| SIMILARITY | Belongs to the chorismate synthase family. |
Keywords
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Gene Ontology
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| GO:0004107; Molecular function:chorismate synthase activity |
| GO:0009423; Biological process:chorismate biosynthetic process |
Cross-references
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| Pfam | PF01264; Chorismate_synt; 1; |
| PIRSF | PIRSF001456; Chorismate_synth; 1; |
| NCBIfam | TIGR00033; AroC; 1; |
| PROSITE | PS00787; CHORISMATE_SYNTHASE_1; 1; |
| PROSITE | PS00788; CHORISMATE_SYNTHASE_2; 1; |
| PROSITE | PS00789; CHORISMATE_SYNTHASE_3; 1; |
Features
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| From: AROC_STRPN (P0A2Y6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 130 | 132 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[RH]-x-S | ||||||||
| BINDING | 251 | 252 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[NQ]-[AGTS] | ||||||||
| BINDING | 311 | 315 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[KH]-x(3)-[TS] | ||||||||
| BINDING | 39 | 39 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
R | ||||||||
| BINDING | 45 | 45 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[RK] | ||||||||
| BINDING | 296 | 296 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[GAS] | ||||||||
| BINDING | 337 | 337 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[RN] | ||||||||
Additional information
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| Size range | 330-422 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |