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HAMAP rule MF_00300

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General rule information [?]

Accession MF_00300
Dates 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 39)
Name Chorismate_synth
Scope(s) Bacteria
Archaea
Template(s) P12008 (AROC_ECOLI); O66493 (AROC_AQUAE); P56122 (AROC_HELPY); P9WPY1 (AROC_MYCTU); P0A2Y6 (AROC_STRPN); Q59803 (AROC_STAAU); [ Recover all ]
Triggered by HAMAP; MF_00300 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AROC
Protein name RecName: Full=Chorismate synthase;
                 Short=CS;
                 EC=4.2.3.5;
AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase;
Gene name Name=aroC;

Comments [?]

FUNCTIONCatalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
CATALYTIC ACTIVITY Reaction=5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate; Xref=Rhea:RHEA:21020, ChEBI:CHEBI:29748, ChEBI:CHEBI:43474, ChEBI:CHEBI:57701; EC=4.2.3.5;
COFACTOR Name=FMNH2; Xref=ChEBI:CHEBI:57618; Note=Reduced FMN (FMNH(2)).;
PATHWAYMetabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.
case <OC:Bacteria>
SUBUNITHomotetramer.
end case
SIMILARITYBelongs to the chorismate synthase family.

Keywords [?]


Gene Ontology [?]

GO:0004107; Molecular function:chorismate synthase activity
GO:0009423; Biological process:chorismate biosynthetic process

Cross-references [?]

Pfam PF01264; Chorismate_synt; 1;
PIRSF PIRSF001456; Chorismate_synth; 1;
NCBIfam TIGR00033; AroC; 1;
PROSITE PS00787; CHORISMATE_SYNTHASE_1; 1;
PROSITE PS00788; CHORISMATE_SYNTHASE_2; 1;
PROSITE PS00789; CHORISMATE_SYNTHASE_3; 1;

Features [?]

From: AROC_STRPN (P0A2Y6)
Key From To Description Tag Condition FTGroup
BINDING 130 132 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[RH]-x-S
BINDING 251 252 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[NQ]-[AGTS]
BINDING 311 315 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[KH]-x(3)-[TS]
BINDING 39 39 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
R
BINDING 45 45 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
[RK]
BINDING 296 296 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[GAS]
BINDING 337 337 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[RN]

Additional information [?]

Size range 330-422 amino acids
Related rules None
Fusion Nter: None Cter: None



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