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Annotation rule MF_00300 |
Accession | MF_00300 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 35) |
Name | Chorismate_synth |
Scope | Bacteria
Archaea |
Templates | P12008 (AROC_ECOLI); O66493 (AROC_AQUAE); P56122 (AROC_HELPY); P9WPY1 (AROC_MYCTU); P0A2Y6 (AROC_STRPN); Q59803 (AROC_STAAU): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. |
Catalytic activity | RHEA:21020: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
EC 4.2.3.5 |
Cofactor | FMNH2 Note: Reduced FMN (FMNH(2)). |
Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. |
Subunit | Homotetramer. |
Similarity | Belongs to the chorismate synthase family. |
Pfam | PF01264; Chorismate_synt; 1; |
PIRSF | PIRSF001456; Chorismate_synth; 1; |
TIGRFAMs | TIGR00033; AroC; 1; |
PROSITE | PS00787; CHORISMATE_SYNTHASE_1; 1; |
PS00788; CHORISMATE_SYNTHASE_2; 1; | |
PS00789; CHORISMATE_SYNTHASE_3; 1; |
From: AROC_STRPN (P0A2Y6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 130 | 132 | FMN | [RH]-x-S | ||||||||
NP_BIND | 251 | 252 | FMN | [NQ]-[AGTS] | ||||||||
NP_BIND | 311 | 315 | FMN | [KH]-x(3)-[TS] | ||||||||
BINDING | 39 | 39 | NADP | R | ||||||||
BINDING | 45 | 45 | NADP | [RK] | ||||||||
BINDING | 296 | 296 | FMN; via amide nitrogen | [GAS] | ||||||||
BINDING | 337 | 337 | FMN | [RN] |
Size range | 330-422 amino acids |
Related rules | None |
Fusion | None |