Home  |  Contact
Annotation rule MF_00300
Send feedback

General rule information [?]

Accession MF_00300
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 35)
Name Chorismate_synth
Scope
Bacteria
Archaea
Templates P12008 (AROC_ECOLI); O66493 (AROC_AQUAE); P56122 (AROC_HELPY); P9WPY1 (AROC_MYCTU); P0A2Y6 (AROC_STRPN); Q59803 (AROC_STAAU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AROC
Protein name
RecName: Full=Chorismate synthase;
Short=CS;
EC 4.2.3.5;
AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase;
Gene name
aroC

Comments [?]

Function Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Catalytic activity RHEA:21020: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
EC 4.2.3.5
Cofactor FMNH2
Note: Reduced FMN (FMNH(2)).
Pathway Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.
case <OC:Bacteria>
Subunit Homotetramer.
end case
Similarity Belongs to the chorismate synthase family.

Keywords [?]

Amino-acid biosynthesis
Aromatic amino acid biosynthesis
FAD
Flavoprotein
FMN
Lyase
NADP

Gene Ontology [?]

GO:0004107; Molecular function: chorismate synthase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

Cross-references [?]

Pfam PF01264; Chorismate_synt; 1;
PIRSF PIRSF001456; Chorismate_synth; 1;
TIGRFAMs TIGR00033; AroC; 1;
PROSITE PS00787; CHORISMATE_SYNTHASE_1; 1;
PS00788; CHORISMATE_SYNTHASE_2; 1;
PS00789; CHORISMATE_SYNTHASE_3; 1;

Features [?]

From: AROC_STRPN (P0A2Y6)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     130     132       FMN     [RH]-x-S  
NP_BIND     251     252       FMN     [NQ]-[AGTS]  
NP_BIND     311     315       FMN     [KH]-x(3)-[TS]  
BINDING     39     39       NADP     R  
BINDING     45     45       NADP     [RK]  
BINDING     296     296       FMN; via amide nitrogen     [GAS]  
BINDING     337     337       FMN     [RN]  

Additional information [?]

Size range 330-422 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)