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HAMAP rule MF_00303

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General rule information [?]

Accession MF_00303
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 27)
Name Trigger_factor_Tig
Scope(s) Bacteria
Template(s) P0A850 (TIG_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00303 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TIG
Protein name RecName: Full=Trigger factor;
                 Short=TF;
                 EC=5.2.1.8;
AltName: Full=PPIase;
Gene name Name=tig;

Comments [?]

FUNCTIONInvolved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
CATALYTIC ACTIVITY Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;
case <OC:Escherichia> or <OC:Shigella>
SUBUNITHomodimer and monomer. In vivo most of the ribosomes are in complex with monomeric TF. Uncomplexed TF, however, is in a monomer- dimer equilibrium with approximately two thirds of TF existing in a dimeric state.
end case
SUBCELLULAR LOCATIONCytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
DOMAINConsists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
SIMILARITYBelongs to the FKBP-type PPIase family. Tig subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003755; Molecular function:peptidyl-prolyl cis-trans isomerase activity
GO:0006457; Biological process:protein folding
GO:0015031; Biological process:protein transport

Cross-references [?]

Pfam PF00254; FKBP_C; 1;
Pfam PF05698; Trigger_C; 1;
Pfam PF05697; Trigger_N; 1;
PIRSF PIRSF003095; Trigger_factor; 1;
NCBIfam TIGR00115; Tig; 1;
PROSITE PS50059; FKBP_PPIASE; 1;

Features [?]


Additional information [?]

Size range 404-557 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong start in AQUAE



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