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Annotation rule MF_00315
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General rule information [?]

Accession MF_00315
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 35)
Name DXP_synth
Scope
Bacteria
Templates P77488 (DXS_ECOLI); Q9RUB5 (DXS_DEIRA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DXS
Protein name
RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase;
EC 2.2.1.7;
AltName: Full=1-deoxyxylulose-5-phosphate synthase;
Short=DXP synthase;
Short=DXPS;
Gene name
dxs

Comments [?]

Function Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Catalytic activity RHEA:12605: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2
EC 2.2.1.7
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
thiamine diphosphate
Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.
Subunit Homodimer.
Similarity Belongs to the transketolase family. DXPS subfamily.

Keywords [?]

Magnesium
Metal-binding
Transferase
Thiamine pyrophosphate
Isoprene biosynthesis
Thiamine biosynthesis

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0008661; Molecular function: 1-deoxy-D-xylulose-5-phosphate synthase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0016114; Biological process: terpenoid biosynthetic process.
GO:0009228; Biological process: thiamine biosynthetic process.

Cross-references [?]

TIGRFAMs TIGR00204; Dxs; 1;
PROSITE PS00801; TRANSKETOLASE_1; 1;
PS00802; TRANSKETOLASE_2; 1;

Features [?]

From: DXS_ECOLI (P77488)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     121     123       /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937     [GAS]-x-[SAT]  
BINDING     153     154       /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937     [GA]-[ASTG]  
BINDING     152     152       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D  
BINDING     181     181       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     N  
BINDING     80     80       /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937     H  
BINDING     181     181       /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937     N  
BINDING (Optional)     288     288       /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937     [YFH]  
BINDING     370     370       /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937     E  

Additional information [?]

Size range 583-680 amino acids
Related rules None
Fusion None
Comments Atypical sequences in BUCAP and LISMO with internal deletions not taken into account in size range and alignment


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