HAMAP rule MF_00315
General rule information
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Accession | MF_00315 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 36) |
Name | DXP_synth |
Scope | Bacteria |
Templates | P77488 (DXS_ECOLI); Q9RUB5 (DXS_DEIRA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP). |
Catalytic activity | RHEA:12605: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2
EC 2.2.1.7 |
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
thiamine diphosphate Note: Binds 1 thiamine pyrophosphate per subunit. |
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Pathway | Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. |
Subunit | Homodimer. |
Similarity | Belongs to the transketolase family. DXPS subfamily. |
Keywords
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Magnesium
Metal-binding
Transferase
Thiamine pyrophosphate
Isoprene biosynthesis
Thiamine biosynthesis
Metal-binding
Transferase
Thiamine pyrophosphate
Isoprene biosynthesis
Thiamine biosynthesis
Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0008661; Molecular function: 1-deoxy-D-xylulose-5-phosphate synthase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0016114; Biological process: terpenoid biosynthetic process.
GO:0009228; Biological process: thiamine biosynthetic process.
GO:0008661; Molecular function: 1-deoxy-D-xylulose-5-phosphate synthase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0016114; Biological process: terpenoid biosynthetic process.
GO:0009228; Biological process: thiamine biosynthetic process.
Cross-references
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Features
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From: DXS_ECOLI (P77488) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 121 | 123 | /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 | [GAS]-x-[SAT] | ||||||||
BINDING | 153 | 154 | /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 | [GA]-[ASTG] | ||||||||
BINDING | 152 | 152 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING | 181 | 181 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | N | ||||||||
BINDING | 80 | 80 | /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 | H | ||||||||
BINDING | 181 | 181 | /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 | N | ||||||||
BINDING (Optional) | 288 | 288 | /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 | [YFH] | ||||||||
BINDING | 370 | 370 | /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 | E |
Additional information
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Size range | 583-680 amino acids |
Related rules | None |
Fusion | None |
Comments | Atypical sequences in BUCAP and LISMO with internal deletions not taken into account in size range and alignment |