HAMAP rule MF_00315

General rule information [?]

Accession	MF_00315
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 36)

Name

DXP_synth

Scope

Bacteria

Templates

P77488 (DXS_ECOLI); Q9RUB5 (DXS_DEIRA): [Recover all]

Triggered by

HAMAP; MF_00315 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DXS

Protein name

RecName:		Full=1-deoxy-D-xylulose-5-phosphate synthase;
		EC 2.2.1.7;
AltName:		Full=1-deoxyxylulose-5-phosphate synthase;
		Short=DXP synthase;
		Short=DXPS;

Gene name

dxs

Comments [?]

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Catalytic activity	RHEA:12605: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2 EC 2.2.1.7
Cofactor	Mg(2+) Note: Binds 1 Mg(2+) ion per subunit.
	thiamine diphosphate Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.
Subunit	Homodimer.
Similarity	Belongs to the transketolase family. DXPS subfamily.

Keywords [?]

Magnesium
Metal-binding
Transferase
Thiamine pyrophosphate
Isoprene biosynthesis
Thiamine biosynthesis

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0008661; Molecular function: 1-deoxy-D-xylulose-5-phosphate synthase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0016114; Biological process: terpenoid biosynthetic process.
GO:0009228; Biological process: thiamine biosynthetic process.

Cross-references [?]

NCBIfam	TIGR00204; Dxs; 1;
PROSITE	PS00801; TRANSKETOLASE_1; 1;
	PS00802; TRANSKETOLASE_2; 1;

Features [?]

From: DXS_ECOLI (P77488)

Key From To Description Tag Condition FTGroup

BINDING 121 123 /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 [GAS]-x-[SAT]

BINDING 153 154 /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 [GA]-[ASTG]

BINDING 152 152 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

BINDING 181 181 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 N

BINDING 80 80 /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 H

BINDING 181 181 /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 N

BINDING (Optional) 288 288 /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 [YFH]

BINDING 370 370 /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937 E

Additional information [?]

Size range	583-680 amino acids
Related rules	None
Fusion	None
Comments	Atypical sequences in BUCAP and LISMO with internal deletions not taken into account in size range and alignment

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