HAMAP rule MF_00316

General rule information [?]

Accession	MF_00316
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 35)

Name

MobA

Scope

Bacteria

Archaea

Template

P32173 (MOBA_ECOLI)

Triggered by

HAMAP; MF_00316 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MOBA

case <OC:Pseudomonadota>

Protein name

RecName:		Full=Molybdenum cofactor guanylyltransferase;
		Short=MoCo guanylyltransferase;
		EC 2.7.7.77;
AltName:		Full=GTP:molybdopterin guanylyltransferase;
AltName:		Full=Molybdopterin-guanine dinucleotide synthase;
		Short=MGD synthase;
AltName:		Full=Molybdopterin guanylyltransferase;
AltName:		Full=Mo-MPT guanylyltransferase;

else

Protein name

RecName:		Full=Probable molybdenum cofactor guanylyltransferase;
		Short=MoCo guanylyltransferase;
		EC 2.7.7.77;
AltName:		Full=GTP:molybdopterin guanylyltransferase;
AltName:		Full=Molybdopterin-guanine dinucleotide synthase;
		Short=MGD synthase;
AltName:		Full=Molybdopterin guanylyltransferase;
AltName:		Full=Mo-MPT guanylyltransferase;

end case

Gene name

mobA

Comments [?]

Function	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Catalytic activity	RHEA:34243: GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide EC 2.7.7.77
Cofactor	Mg(2+)

case <OC:Pseudomonadota>

Subunit

Monomer.

end case

Domain	The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Subcellular location	Cytoplasm.
Similarity	Belongs to the MobA family.

Keywords [?]

Cytoplasm
GTP-binding
Magnesium
Metal-binding
Molybdenum cofactor biosynthesis
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0070568; Molecular function: guanylyltransferase activity.
GO:0019720; Biological process: Mo-molybdopterin cofactor metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

NCBIfam

TIGR02665; Molyb_mobA; 1;

Features [?]

From: MOBA_ECOLI (P32173)

Key From To Description Tag Condition FTGroup

BINDING 12 14 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 [LFIVT]-x-G

BINDING 101 101 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

BINDING 25 25 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 [KR]

BINDING (Optional) 53 53 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 [NRHK]

BINDING (Optional) 71 71 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 D

BINDING 101 101 /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 D

Additional information [?]

Size range	189-225 amino acids
Related rules	None
Fusion	Nter: MF_01224 (moaC); Cter: None

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