HAMAP rule MF_00322

General rule information [?]

Accession	MF_00322
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 34)

Name

Top6B

Scope

Archaea

Bacteria

Templates

O05207 (TOP6B_SACSH); Q8PUB8 (TOP6B_METMA): [Recover all]

case <OC:Bacteria> or <OC:Archaea>

Triggered by

HAMAP; MF_00322 (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TOP6B

Protein name

RecName:		Full=Type 2 DNA topoisomerase 6 subunit B;
		EC 5.6.2.2;
AltName:		Full=Type II DNA topoisomerase VI subunit B;
		Short=TopoVI-B;

Gene name

top6B

Comments [?]

Function	Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Catalytic activity	Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2;
Subunit	Homodimer. Heterotetramer of two Top6A and two Top6B chains.
Similarity	Belongs to the TOP6B family.

Keywords [?]

ATP-binding
DNA-binding
Isomerase
Nucleotide-binding
Topoisomerase

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0006265; Biological process: DNA topological change.
GO:0006268; Biological process: DNA unwinding involved in DNA replication.

Cross-references [?]

Pfam	PF02518; HATPase_c; 1;
	PF09239; Topo-VIb_trans; 1;
TIGRFAMs	TIGR01052; top6b; 1;
PIRSF	PIRSF006553; TopoVI_B; 1;

Features [?]

From: TOP6B_SACSH (O05207)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 97 98 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [ST]-[KR]

BINDING (Optional) 106 113 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-x-x-G-[LIV]-G-x-[KSA]

BINDING (Optional) 42 42 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 N

BINDING (Optional) 76 76 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 D

BINDING (Optional) 427 427 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 K

Additional information [?]

Size range	475-842 amino acids
Related rules	None
Fusion	None

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