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HAMAP rule MF_00322

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General rule information [?]

Accession MF_00322
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 35)
Name Top6B
Scope(s) Archaea
Template(s) O05207 (TOP6B_SACSH); Q8PUB8 (TOP6B_METMA); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_00322 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TOP6B
Protein name RecName: Full=Type 2 DNA topoisomerase 6 subunit B;
AltName: Full=Type II DNA topoisomerase VI subunit B;
Gene name Name=top6B;

Comments [?]

FUNCTIONRelaxes both positive and negative superturns and exhibits a strong decatenase activity.
CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=;
SUBUNITHomodimer. Heterotetramer of two Top6A and two Top6B chains.
SIMILARITYBelongs to the TOP6B family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0006265; Biological process:DNA topological change
GO:0006268; Biological process:DNA unwinding involved in DNA replication

Cross-references [?]

Pfam PF02518; HATPase_c; 1;
Pfam PF09239; Topo-VIb_trans; 1;
NCBIfam TIGR01052; top6b; 1;
PIRSF PIRSF006553; TopoVI_B; 1;

Features [?]

From: TOP6B_SACSH (O05207)
Key From To Description Tag Condition FTGroup
BINDING 97 98 /ligand="ATP"
BINDING 106 113 /ligand="ATP"
BINDING 42 42 /ligand="ATP"
BINDING 76 76 /ligand="ATP"
BINDING 427 427 /ligand="ATP"

Additional information [?]

Size range 475-842 amino acids
Related rules None
Fusion Nter: None Cter: None

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