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HAMAP rule MF_00322

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General rule information [?]

Accession MF_00322
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 34)
Name Top6B
Templates O05207 (TOP6B_SACSH); Q8PUB8 (TOP6B_METMA): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Type 2 DNA topoisomerase 6 subunit B;
AltName: Full=Type II DNA topoisomerase VI subunit B;
Gene name

Comments [?]

Function Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Catalytic activity Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=;
Subunit Homodimer. Heterotetramer of two Top6A and two Top6B chains.
Similarity Belongs to the TOP6B family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0006265; Biological process: DNA topological change.
GO:0006268; Biological process: DNA unwinding involved in DNA replication.

Cross-references [?]

Pfam PF02518; HATPase_c; 1;
PF09239; Topo-VIb_trans; 1;
TIGRFAMs TIGR01052; top6b; 1;
PIRSF PIRSF006553; TopoVI_B; 1;

Features [?]

From: TOP6B_SACSH (O05207)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     97     98       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [ST]-[KR]  
BINDING (Optional)     106     113       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-x-x-G-[LIV]-G-x-[KSA]  
BINDING (Optional)     42     42       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     N  
BINDING (Optional)     76     76       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     D  
BINDING (Optional)     427     427       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     K  

Additional information [?]

Size range 475-842 amino acids
Related rules None
Fusion None