HAMAP rule MF_00322

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00322
Accession	MF_00322
Dates	28-FEB-2005 (Created) 14-JAN-2025 (Last updated, Version 27)
Name	Top6B
Scope(s)	Archaea Bacteria
Template(s)	O05207; Q8PUB8; [ Recover all ]
Triggered by	case c? <OC:Bacteria> or <OC:Archaea> HAMAP; MF_00322 (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TOP6B
Protein name	RecName: Full=Type 2 DNA topoisomerase 6 subunit B; EC=5.6.2.2; AltName: Full=Type II DNA topoisomerase VI subunit B; Short=TopoVI-B;
Gene name	Name=top6B;

Comments [?]

FUNCTION	Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
CATALYTIC ACTIVITY	Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2;
SUBUNIT	Homodimer. Heterotetramer of two Top6A and two Top6B chains.
SIMILARITY	Belongs to the TOP6B family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0003677; Molecular function:DNA binding

GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

GO:0006265; Biological process:DNA topological change

GO:0006260; Biological process:DNA replication

Cross-references [?]

Features [?]

From: TOP6B_SACSH (O05207)

Key

From

Description

Tag

Condition

FTGroup

BINDING