HAMAP rule MF_00322
General rule information
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Accession | MF_00322 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 34) |
Name | Top6B |
Scope | Archaea
Bacteria |
Templates | O05207 (TOP6B_SACSH); Q8PUB8 (TOP6B_METMA): [Recover all] |
case <OC:Bacteria> or <OC:Archaea>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Relaxes both positive and negative superturns and exhibits a strong decatenase activity. |
Catalytic activity | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
Subunit | Homodimer. Heterotetramer of two Top6A and two Top6B chains. |
Similarity | Belongs to the TOP6B family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0006265; Biological process: DNA topological change.
GO:0006268; Biological process: DNA unwinding involved in DNA replication.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0006265; Biological process: DNA topological change.
GO:0006268; Biological process: DNA unwinding involved in DNA replication.
Cross-references
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Pfam | PF02518; HATPase_c; 1; |
PF09239; Topo-VIb_trans; 1; | |
TIGRFAMs | TIGR01052; top6b; 1; |
PIRSF | PIRSF006553; TopoVI_B; 1; |
Features
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From: TOP6B_SACSH (O05207) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 97 | 98 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [ST]-[KR] | ||||||||
BINDING (Optional) | 106 | 113 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-x-x-G-[LIV]-G-x-[KSA] | ||||||||
BINDING (Optional) | 42 | 42 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | N | ||||||||
BINDING (Optional) | 76 | 76 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | D | ||||||||
BINDING (Optional) | 427 | 427 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K |
Additional information
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Size range | 475-842 amino acids |
Related rules | None |
Fusion | None |