HAMAP logo

HAMAP rule MF_00323

Send feedback

General rule information [?]

Accession MF_00323
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 48)
Name Ferrochelatase
Scope
Bacteria
Archaea
Templates P32396 (CPFC_BACSU); P23871 (HEMH_ECOLI); Q8Y565 (CPFC_LISMO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Bacillota> or <OC:Actinomycetota>
Identifier
CPFC
Protein name
RecName: Full=Coproporphyrin III ferrochelatase;
EC 4.99.1.9;
Gene name
cpfC
else
Identifier
HEMH
Protein name
RecName: Full=Ferrochelatase;
EC 4.98.1.1;
AltName: Full=Heme synthase;
AltName: Full=Protoheme ferro-lyase;
Gene name
hemH
end case

Comments [?]

case <OC:Bacillota> or <OC:Actinomycetota>
Function Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
Catalytic activity RHEA:49572: Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)
EC 4.99.1.9
PhysiologicalDirection=right-to-left (RHEA:49574)
Pathway Porphyrin-containing compound metabolism; protoheme biosynthesis.
else
Function Catalyzes the ferrous insertion into protoporphyrin IX.
Catalytic activity RHEA:22584: 2 H(+) + heme b = Fe(2+) + protoporphyrin IX
EC 4.98.1.1
Pathway Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Subunit Monomer.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the ferrochelatase family.

Keywords [?]

Cytoplasm
Porphyrin biosynthesis
Heme biosynthesis
Lyase
Iron
Metal-binding

Gene Ontology [?]

GO:0004325; Molecular function: ferrochelatase activity.
GO:0006783; Biological process: heme biosynthetic process.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00762; Ferrochelatase; 1;
NCBIfam TIGR00109; HemH; 1;
PROSITE PS00534; FERROCHELATASE; 1;

Features [?]

From: CPFC_LISMO (Q8Y565)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     182     182       /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033     H  
BINDING     263     263       /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033     E  
case <OC:Bacillota> or <OC:Actinomycetota>
BINDING (Optional)     45     46       /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438     R-Y  
BINDING (Optional)     12     12       /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     Y  
BINDING (Optional)     29     29       /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438     R  
BINDING (Optional)     53     53       /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438     S  
BINDING (Optional)     124     124       /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438     Y  
end case

Additional information [?]

Size range 303-391 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)