HAMAP rule MF_00324
General rule information
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Accession | MF_00324 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 31) |
Name | DNApol_II_L_arch |
Scope(s) |
Archaea |
Template(s) | Q59024 (DP2L_METJA); P81409 (DP2L_PYRFU); [ Recover all ] |
Triggered by |
HAMAP; MF_00324 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DP2L |
Protein name | RecName: Full=DNA polymerase II large subunit; Short=Pol II; EC=2.7.7.7; AltName: Full=Exodeoxyribonuclease large subunit; EC=3.1.11.1; |
Gene name | Name=polC; |
Comments
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FUNCTION | Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. |
CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; |
CATALYTIC ACTIVITY | Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.1; |
SUBUNIT | Heterodimer of a large subunit and a small subunit. |
SIMILARITY | Belongs to the archaeal DNA polymerase II family. |
Keywords
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Transferase |
Nucleotidyltransferase |
DNA-directed DNA polymerase |
DNA replication |
Hydrolase |
Nuclease |
Exonuclease |
DNA-binding |
Multifunctional enzyme |
Gene Ontology
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GO:0008408; Molecular function:3'-5' exonuclease activity |
GO:0003677; Molecular function:DNA binding |
GO:0003887; Molecular function:DNA-directed DNA polymerase activity |
GO:0006308; Biological process:DNA catabolic process |
GO:0006261; Biological process:DNA-templated DNA replication |
Cross-references
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Features
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Additional information
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Size range | 1080-1270 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Inteins deleted in HALMA, HALWD, HALSA, METMJ, METHJ, PYRAB, PYRHO and THEKO. |