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Annotation rule MF_00324
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General rule information [?]

Accession MF_00324
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 27)
Name DNApol_II_L_arch
Templates Q59024 (DP2L_METJA); P81409 (DP2L_PYRFU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA polymerase II large subunit;
Short=Pol II;
AltName: Full=Exodeoxyribonuclease large subunit;
Gene name

Comments [?]

Function Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Catalytic activity RHEA:22508: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=;
Subunit Heterodimer of a large subunit and a small subunit.
Similarity Belongs to the archaeal DNA polymerase II family.

Keywords [?]

Gene Ontology [?]

GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000738; Biological process: DNA catabolic process, exonucleolytic.
GO:0006261; Biological process: DNA-dependent DNA replication.

Cross-references [?]

Pfam PF03833; PolC_DP2; 1;
TIGRFAMs TIGR00354; PolC; 1;

Additional information [?]

Size range 1080-1270 amino acids
Related rules None
Fusion None
Comments Inteins deleted in HALMA, HALWD, HALSA, METMJ, METHJ, PYRAB, PYRHO and THEKO.