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HAMAP rule MF_00324

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General rule information [?]

Accession MF_00324
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 31)
Name DNApol_II_L_arch
Scope(s) Archaea
Template(s) Q59024 (DP2L_METJA); P81409 (DP2L_PYRFU); [ Recover all ]
Triggered by HAMAP; MF_00324 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DP2L
Protein name RecName: Full=DNA polymerase II large subunit;
                 Short=Pol II;
AltName: Full=Exodeoxyribonuclease large subunit;
Gene name Name=polC;

Comments [?]

FUNCTIONPossesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
CATALYTIC ACTIVITY Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=;
CATALYTIC ACTIVITY Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=;
SUBUNITHeterodimer of a large subunit and a small subunit.
SIMILARITYBelongs to the archaeal DNA polymerase II family.

Keywords [?]

Gene Ontology [?]

GO:0008408; Molecular function:3'-5' exonuclease activity
GO:0003677; Molecular function:DNA binding
GO:0003887; Molecular function:DNA-directed DNA polymerase activity
GO:0006308; Biological process:DNA catabolic process
GO:0006261; Biological process:DNA-templated DNA replication

Cross-references [?]

Pfam PF03833; PolC_DP2; 1;
NCBIfam TIGR00354; PolC; 1;

Features [?]

Additional information [?]

Size range 1080-1270 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Inteins deleted in HALMA, HALWD, HALSA, METMJ, METHJ, PYRAB, PYRHO and THEKO.

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