HAMAP rule MF_00324

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00324
Accession	MF_00324
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 22)
Name	DNApol_II_L_arch
Scope(s)	Archaea
Template(s)	Q59024; P81409; [ Recover all ]
Triggered by	HAMAP; MF_00324 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DP2L
Protein name	RecName: Full=DNA polymerase II large subunit; Short=Pol II; EC=2.7.7.7; AltName: Full=Exodeoxyribonuclease large subunit; EC=3.1.11.1;
Gene name	Name=polC;

Comments [?]

FUNCTION	Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
CATALYTIC ACTIVITY	Reaction=DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate; Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7;
CATALYTIC ACTIVITY	Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.1;
SUBUNIT	Heterodimer of a large subunit and a small subunit.
SIMILARITY	Belongs to the archaeal DNA polymerase II family.

Keywords [?]

Gene Ontology [?]

GO:0008408; Molecular function:3'-5' exonuclease activity

GO:0003677; Molecular function:DNA binding

GO:0003887; Molecular function:DNA-directed DNA polymerase activity

GO:0006308; Biological process:DNA catabolic process

GO:0006261; Biological process:DNA-templated DNA replication

Cross-references [?]

Pfam	PF03833; PolC_DP2; 1;
NCBIfam	TIGR00354; PolC; 1;

Features [?]

Additional information [?]

Size range	1080-1270 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	Inteins deleted in HALMA, HALWD, HALSA, METMJ, METHJ, PYRAB, PYRHO and THEKO.