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HAMAP rule MF_00332

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General rule information [?]

Accession MF_00332
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 55)
Name DnaK
Scope(s) Bacteria
Archaea
Plastid
Template(s) P0A6Y8 (DNAK_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00332 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DNAK
Protein name RecName: Full=Chaperone protein DnaK;
AltName: Full=HSP70;
AltName: Full=Heat shock 70 kDa protein;
AltName: Full=Heat shock protein 70;
Gene name Name=dnaK;

Comments [?]

FUNCTIONActs as a chaperone.
case <OC:Bacteria>
INDUCTIONBy stress conditions e.g. heat shock.
end case
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the heat shock protein 70 family.

Keywords [?]

case <FT:2> or <FT:3> or <FT:4> or <FT:5> or <FT:6>
Acetylation
end case
ATP-binding
Chaperone
Nucleotide-binding
case <OC:Bacteria>
Stress response
end case
case <OC:Bacteria> and <FT:1>
Phosphoprotein
end case

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF00012; HSP70; 1;
PRINTS PR00301; HEATSHOCK70; 1;
PROSITE PS00297; HSP70_1; 1;
PROSITE PS00329; HSP70_2; 1;
PROSITE PS01036; HSP70_3; 1;
NCBIfam TIGR02350; prok_dnaK; 1;

Features [?]

From: DNAK_ECOLI (P0A6Y8)
Key From To Description Tag Condition FTGroup
case <OC:Bacteria>
MOD_RES 199 199 /note="Phosphothreonine; by autocatalysis" T
end case
case <OC:Escherichia> or <OC:Shigella>
MOD_RES 109 109 /note="N6-acetyllysine" K
MOD_RES 245 245 /note="N6-acetyllysine" K
MOD_RES 304 304 /note="N6-acetyllysine" K
MOD_RES 421 421 /note="N6-acetyllysine" K
MOD_RES 556 556 /note="N6-acetyllysine" K
end case

Additional information [?]

Size range 591-771 amino acids
Related rules MF_00679
Fusion Nter: None Cter: None
Comments Cyanobacteriota have 3 copies of dnaK, only the second one (dnaK2) is represented in this alignment. The two others are divergent and longer



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