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HAMAP rule MF_00332
General rule information
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| Accession | MF_00332 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 55) |
| Name | DnaK |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | P0A6Y8 (DNAK_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00332 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DNAK |
| Protein name | RecName: Full=Chaperone protein DnaK; AltName: Full=HSP70; AltName: Full=Heat shock 70 kDa protein; AltName: Full=Heat shock protein 70; |
| Gene name | Name=dnaK; |
Comments
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| FUNCTION | Acts as a chaperone. |
| case <OC:Bacteria> | |
| INDUCTION | By stress conditions e.g. heat shock. |
| end case | |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the heat shock protein 70 family. |
Keywords
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| case <FT:2> or <FT:3> or <FT:4> or <FT:5> or <FT:6> | |
| Acetylation | |
| end case | |
| ATP-binding | |
| Chaperone | |
| Nucleotide-binding | |
| case <OC:Bacteria> | |
| Stress response | |
| end case | |
| case <OC:Bacteria> and <FT:1> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
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| Pfam | PF00012; HSP70; 1; |
| PRINTS | PR00301; HEATSHOCK70; 1; |
| PROSITE | PS00297; HSP70_1; 1; |
| PROSITE | PS00329; HSP70_2; 1; |
| PROSITE | PS01036; HSP70_3; 1; |
| NCBIfam | TIGR02350; prok_dnaK; 1; |
Features
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| From: DNAK_ECOLI (P0A6Y8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> | ||||||||||||
| MOD_RES | 199 | 199 | /note="Phosphothreonine; by autocatalysis" | T | ||||||||
| end case | ||||||||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| MOD_RES | 109 | 109 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 245 | 245 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 304 | 304 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 421 | 421 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 556 | 556 | /note="N6-acetyllysine" | K | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 591-771 amino acids |
| Related rules |
MF_00679 |
| Fusion | Nter: None Cter: None |
| Comments | Cyanobacteriota have 3 copies of dnaK, only the second one (dnaK2) is represented in this alignment. The two others are divergent and longer |