HAMAP logo

HAMAP rule MF_00334

Send feedback

General rule information [?]

Accession MF_00334
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 31)
Name Homogentis_dioxygen
Templates Q88E47 (HGD_PSEPK); Q6EMI9 (HGD_PSEPU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Homogentisate 1,2-dioxygenase;
AltName: Full=Homogentisate oxygenase;
AltName: Full=Homogentisic acid oxidase;
AltName: Full=Homogentisicase;
Gene name

Comments [?]

Function Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
Catalytic activity RHEA:15449: homogentisate + O2 = 4-maleylacetoacetate + H(+)
Cofactor Fe cation
Pathway Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.
Subunit Hexamer; dimer of trimers.
Similarity Belongs to the homogentisate dioxygenase family.

Keywords [?]

Gene Ontology [?]

GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity.
GO:0005506; Molecular function: iron ion binding.
GO:0006559; Biological process: L-phenylalanine catabolic process.
GO:0006572; Biological process: tyrosine catabolic process.

Cross-references [?]

Pfam PF04209; HgmA; 1;
TIGRFAMs TIGR01015; HmgA; 1;

Features [?]

From: HGD_PSEPK (Q88E47)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     288     288       Proton acceptor     H  
BINDING     349     349       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     H  
BINDING     355     355       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     E  
BINDING     385     385       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     H  
BINDING     346     346       /ligand="homogentisate" /ligand_id="ChEBI:CHEBI:16169     y  
BINDING     367     367       /ligand="homogentisate" /ligand_id="ChEBI:CHEBI:16169     H  

Additional information [?]

Size range 416-458 amino acids
Related rules None
Fusion None