HAMAP rule MF_00334
General rule information
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Accession | MF_00334 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 31) |
Name | Homogentis_dioxygen |
Scope | Bacteria |
Templates | Q88E47 (HGD_PSEPK); Q6EMI9 (HGD_PSEPU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. |
Catalytic activity | RHEA:15449: homogentisate + O2 = 4-maleylacetoacetate + H(+)
EC 1.13.11.5 |
Cofactor | Fe cation |
Pathway | Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. |
Subunit | Hexamer; dimer of trimers. |
Similarity | Belongs to the homogentisate dioxygenase family. |
Keywords
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Gene Ontology
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GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity.
GO:0005506; Molecular function: iron ion binding.
GO:0006559; Biological process: L-phenylalanine catabolic process.
GO:0006572; Biological process: tyrosine catabolic process.
GO:0005506; Molecular function: iron ion binding.
GO:0006559; Biological process: L-phenylalanine catabolic process.
GO:0006572; Biological process: tyrosine catabolic process.
Cross-references
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Features
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From: HGD_PSEPK (Q88E47) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 288 | 288 | Proton acceptor | H | ||||||||
BINDING | 349 | 349 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | H | ||||||||
BINDING | 355 | 355 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | E | ||||||||
BINDING | 385 | 385 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | H | ||||||||
BINDING | 346 | 346 | /ligand="homogentisate" /ligand_id="ChEBI:CHEBI:16169 | y | ||||||||
BINDING | 367 | 367 | /ligand="homogentisate" /ligand_id="ChEBI:CHEBI:16169 | H |
Additional information
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Size range | 416-458 amino acids |
Related rules | None |
Fusion | None |