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HAMAP rule MF_00334

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General rule information [?]

Accession MF_00334
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 33)
Name Homogentis_dioxygen
Scope(s) Bacteria
Template(s) Q88E47 (HGD_PSEPK); Q6EMI9 (HGD_PSEPU); [ Recover all ]
Triggered by HAMAP; MF_00334 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HGD
RecName: Full=Homogentisate 1,2-dioxygenase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=HGDO;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/"></a>;<br /> AltName: Full=Homogentisate oxygenase;<br /> AltName: Full=Homogentisic acid oxidase;<br /> AltName: Full=Homogentisicase;
Gene name Name=hmgA;

Comments [?]

FUNCTIONInvolved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
CATALYTIC ACTIVITY Reaction=homogentisate + O2 = 4-maleylacetoacetate + H(+); Xref=Rhea:RHEA:15449, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169, ChEBI:CHEBI:17105; EC=;
COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI:24875;
PATHWAYAmino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.
SUBUNITHexamer; dimer of trimers.
SIMILARITYBelongs to the homogentisate dioxygenase family.

Keywords [?]

Gene Ontology [?]

GO:0004411; Molecular function:homogentisate 1,2-dioxygenase activity
GO:0005506; Molecular function:iron ion binding
GO:0006559; Biological process:L-phenylalanine catabolic process
GO:0006572; Biological process:tyrosine catabolic process

Cross-references [?]

Pfam PF04209; HgmA; 1;
NCBIfam TIGR01015; HmgA; 1;

Features [?]

From: HGD_PSEPK (Q88E47)
Key From To Description Tag Condition FTGroup
ACT_SITE 288 288 /note="Proton acceptor" H
BINDING 349 349 /ligand="Fe cation"
BINDING 355 355 /ligand="Fe cation"
BINDING 385 385 /ligand="Fe cation"
BINDING 346 346 /ligand="homogentisate"
BINDING 367 367 /ligand="homogentisate"

Additional information [?]

Size range 416-458 amino acids
Related rules None
Fusion Nter: None Cter: None

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