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HAMAP rule MF_00334
General rule information
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| Accession | MF_00334 |
| Dates | 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 33) |
| Name | Homogentis_dioxygen |
| Scope(s) |
Bacteria |
| Template(s) | Q88E47 (HGD_PSEPK); Q6EMI9 (HGD_PSEPU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00334 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HGD |
| RecName: Full=Homogentisate 1,2-dioxygenase;<br /> Short=HGDO;<br /> EC=<a href="https://enzyme.expasy.org/EC/1.13.11.5">1.13.11.5</a>;<br /> AltName: Full=Homogentisate oxygenase;<br /> AltName: Full=Homogentisic acid oxidase;<br /> AltName: Full=Homogentisicase; | |
| Gene name | Name=hmgA; |
Comments
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| FUNCTION | Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. |
| CATALYTIC ACTIVITY | Reaction=homogentisate + O2 = 4-maleylacetoacetate + H(+); Xref=Rhea:RHEA:15449, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169, ChEBI:CHEBI:17105; EC=1.13.11.5; |
| COFACTOR | Name=Fe cation; Xref=ChEBI:CHEBI:24875; |
| PATHWAY | Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. |
| SUBUNIT | Hexamer; dimer of trimers. |
| SIMILARITY | Belongs to the homogentisate dioxygenase family. |
Keywords
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Gene Ontology
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| GO:0004411; Molecular function:homogentisate 1,2-dioxygenase activity |
| GO:0005506; Molecular function:iron ion binding |
| GO:0006559; Biological process:L-phenylalanine catabolic process |
| GO:0006572; Biological process:tyrosine catabolic process |
Cross-references
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Features
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| From: HGD_PSEPK (Q88E47) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 288 | 288 | /note="Proton acceptor" | H | ||||||||
| BINDING | 349 | 349 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | ||||||||
| BINDING | 355 | 355 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
E | ||||||||
| BINDING | 385 | 385 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | ||||||||
| BINDING | 346 | 346 | /ligand="homogentisate" /ligand_id="ChEBI:CHEBI:16169" |
y | ||||||||
| BINDING | 367 | 367 | /ligand="homogentisate" /ligand_id="ChEBI:CHEBI:16169" |
H | ||||||||
Additional information
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| Size range | 416-458 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |