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Annotation rule MF_00347
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General rule information [?]

Accession MF_00347
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 30)
Name Polyphosphate_kinase
Scope
Bacteria
Archaea
Templates P0A7B1 (PPK1_ECOLI); Q07411 (PPK1_KLEPN); Q9JXS9 (PPK1_NEIMB): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PPK1
Protein name
RecName: Full=Polyphosphate kinase;
EC 2.7.4.1;
AltName: Full=ATP-polyphosphate phosphotransferase;
AltName: Full=Polyphosphoric acid kinase;
Gene name
ppk

Comments [?]

Function Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
Catalytic activity RHEA:19573: [phosphate](n) + ATP = [phosphate](n+1) + ADP
EC 2.7.4.1
case <FTGroup:1>
Cofactor Mg(2+)
end case
Ptm An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
Similarity Belongs to the polyphosphate kinase 1 (PPK1) family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0008976; Molecular function: polyphosphate kinase activity.
GO:0006799; Biological process: polyphosphate biosynthetic process.

Cross-references [?]

Pfam PF02503; PP_kinase; 1;
PF13090; PP_kinase_C; 1;
PF13089; PP_kinase_N; 1;
PIRSF PIRSF015589; PP_kinase; 1;
TIGRFAMs TIGR03705; poly_P_kin; 1;
PROSITE PS50035; PLD; 0-1; trigger=PRU00153;

Features [?]

From: PPK1_ECOLI (P0A7B1)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     435     435       Phosphohistidine intermediate     H  
METAL     375     375       Magnesium     R   1
METAL     405     405       Magnesium     R   1
BINDING (Optional)     45     45       ATP     N  
BINDING (Optional)     468     468       ATP     Y  
BINDING (Optional)     564     564       ATP     R  
BINDING (Optional)     592     592       ATP     H  

Additional information [?]

Size range 640-850 amino acids
Related rules None
Fusion None