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HAMAP rule MF_00347

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General rule information [?]

Accession MF_00347
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name Polyphosphate_kinase
Scope(s) Bacteria
Template(s) P0A7B1 (PPK1_ECOLI); Q07411 (PPK1_KLEPN); Q9JXS9 (PPK1_NEIMB); [ Recover all ]
Triggered by HAMAP; MF_00347 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PPK1
Protein name RecName: Full=Polyphosphate kinase;
AltName: Full=ATP-polyphosphate phosphotransferase;
AltName: Full=Polyphosphoric acid kinase;
Gene name Name=ppk;

Comments [?]

FUNCTIONCatalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
CATALYTIC ACTIVITY Reaction=[phosphate](n) + ATP = [phosphate](n+1) + ADP; Xref=Rhea:RHEA:19573, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14280, ChEBI:CHEBI:16838, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=;
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
PTMAn intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
SIMILARITYBelongs to the polyphosphate kinase 1 (PPK1) family.

Keywords [?]

Gene Ontology [?]

GO:0008976; Molecular function:polyphosphate kinase activity
GO:0006799; Biological process:polyphosphate biosynthetic process

Cross-references [?]

Pfam PF02503; PP_kinase; 1;
Pfam PF13090; PP_kinase_C; 1;
Pfam PF13089; PP_kinase_N; 1;
PIRSF PIRSF015589; PP_kinase; 1;
NCBIfam TIGR03705; poly_P_kin; 1;
PROSITE PS50035; PLD; 0-1;

Features [?]

From: PPK1_ECOLI (P0A7B1)
Key From To Description Tag Condition FTGroup
ACT_SITE 435 435 /note="Phosphohistidine intermediate" H
BINDING 375 375 /ligand="Mg(2+)"
R 1
BINDING 405 405 /ligand="Mg(2+)"
R 1
BINDING 45 45 /ligand="ATP"
BINDING 468 468 /ligand="ATP"
BINDING 564 564 /ligand="ATP"
BINDING 592 592 /ligand="ATP"

Additional information [?]

Size range 640-850 amino acids
Related rules None
Fusion Nter: None Cter: None

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