HAMAP rule MF_00347

General rule information [?]

Accession	MF_00347
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 33)
Name	Polyphosphate_kinase
Scope(s)	Bacteria Archaea
Template(s)	P0A7B1 (PPK1_ECOLI); Q07411 (PPK1_KLEPN); Q9JXS9 (PPK1_NEIMB); [ Recover all ]
Triggered by	HAMAP; MF_00347 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PPK1
Protein name	RecName: Full=Polyphosphate kinase; EC=2.7.4.1; AltName: Full=ATP-polyphosphate phosphotransferase; AltName: Full=Polyphosphoric acid kinase;
Gene name	Name=ppk;

Comments [?]

FUNCTION	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
CATALYTIC ACTIVITY	Reaction=[phosphate](n) + ATP = [phosphate](n+1) + ADP; Xref=Rhea:RHEA:19573, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14280, ChEBI:CHEBI:16838, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.4.1;
case <FTGroup:1>
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
PTM	An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
SIMILARITY	Belongs to the polyphosphate kinase 1 (PPK1) family.

Keywords [?]

Gene Ontology [?]

GO:0008976; Molecular function:polyphosphate kinase activity

GO:0006799; Biological process:polyphosphate biosynthetic process

Cross-references [?]

Features [?]

From: PPK1_ECOLI (P0A7B1)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

435

/note="Phosphohistidine intermediate"

BINDING

375

/ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"

BINDING

405

/ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"

BINDING

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

BINDING

468

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

BINDING

564

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

BINDING

592

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

Additional information [?]