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HAMAP rule MF_00351
General rule information
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| Accession | MF_00351 |
| Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 20) |
| Name | RNA_methyltransf_FlpA |
| Scope(s) |
Archaea |
| Template(s) | O28192 (FLPA_ARCFU); P58032 (FLPA_SACS2); Q58108 (FLPA_METJA); Q8U4M2 (FLPA_PYRFU); Q9Y9U3 (FLPA_AERPE); [ Recover all ] |
| Triggered by |
HAMAP; MF_00351 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FLPA |
| Protein name | RecName: Full=Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; EC=2.1.1.-; |
| Gene name | Name=flpA; |
Comments
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| FUNCTION | Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. |
| SUBUNIT | Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA. |
| SIMILARITY | Belongs to the methyltransferase superfamily. Fibrillarin family. |
Keywords
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Gene Ontology
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| GO:0003723; Molecular function:RNA binding |
| GO:0008168; Molecular function:methyltransferase activity |
| GO:0006364; Biological process:rRNA processing |
| GO:0008033; Biological process:tRNA processing |
Cross-references
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Features
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| From: FLPA_AERPE (Q9Y9U3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 90 | 91 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[TS]-T | ||||||||
| BINDING | 109 | 110 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ED]-x | ||||||||
| BINDING | 134 | 135 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DN]-[AS] | ||||||||
| BINDING | 154 | 157 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D-[IVL]-[SA]-[QT] | ||||||||
Additional information
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| Size range | 185-245 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The "x" in the condition of the second S-adenosyl-L-methionine-binding region most often is a large and hydrophobic residue (pi-stacking interaction). |