HAMAP logo

HAMAP rule MF_00351

Send feedback

General rule information [?]

Accession MF_00351
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 20)
Name RNA_methyltransf_FlpA
Scope(s) Archaea
Template(s) O28192 (FLPA_ARCFU); P58032 (FLPA_SACS2); Q58108 (FLPA_METJA); Q8U4M2 (FLPA_PYRFU); Q9Y9U3 (FLPA_AERPE); [ Recover all ]
Triggered by HAMAP; MF_00351 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FLPA
Protein name RecName: Full=Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase;
Gene name Name=flpA;

Comments [?]

FUNCTIONInvolved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
SUBUNITInteracts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
SIMILARITYBelongs to the methyltransferase superfamily. Fibrillarin family.

Keywords [?]

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding
GO:0008168; Molecular function:methyltransferase activity
GO:0006364; Biological process:rRNA processing
GO:0008033; Biological process:tRNA processing

Cross-references [?]

Pfam PF01269; Fibrillarin; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 90 91 /ligand="S-adenosyl-L-methionine"
BINDING 109 110 /ligand="S-adenosyl-L-methionine"
BINDING 134 135 /ligand="S-adenosyl-L-methionine"
BINDING 154 157 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 185-245 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The "x" in the condition of the second S-adenosyl-L-methionine-binding region most often is a large and hydrophobic residue (pi-stacking interaction).

View rule in raw text format (no links)