HAMAP rule MF_00356
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00356 |
| Accession | MF_00356 |
| Dates | 1-JUN-2001 (Created)
2-SEP-2024 (Last updated, Version 33) |
| Name | DNApol_PolC |
| Scope(s) |
Bacteria |
| Template(s) | P13267 (DPO3_BACSU); P47729 (DPO3_MYCPU); P0C1P9 (DPO3_STAAU); Q2G1Z8 (DPO3_STAA8); [ Recover all ] |
| Triggered by |
HAMAP; MF_00356 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DPO3 |
| Protein name | RecName: Full=DNA polymerase III PolC-type; Short=PolIII; EC=2.7.7.7; |
| Gene name | Name=polC; |
Comments
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| FUNCTION | Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. |
| CATALYTIC ACTIVITY | Reaction=DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate; Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the DNA polymerase type-C family. PolC subfamily. |
Keywords
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| Cytoplasm |
| Transferase |
| Nucleotidyltransferase |
| DNA-directed DNA polymerase |
| DNA replication |
| Hydrolase |
| Nuclease |
| Exonuclease |
Gene Ontology
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| GO:0008408; Molecular function:3'-5' exonuclease activity |
| GO:0003677; Molecular function:DNA binding |
| GO:0003887; Molecular function:DNA-directed DNA polymerase activity |
| GO:0006261; Biological process:DNA-templated DNA replication |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF07733; DNA_pol3_alpha; 1; |
| Pfam | PF00929; RNase_T; 1; |
| Pfam | PF02811; PHP; 1; |
| Pfam | PF01336; tRNA_anti; 1; |
| NCBIfam | TIGR00573; Dnaq; 1; |
| NCBIfam | TIGR01405; PolC_Gram_pos; 1; |
Features
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Additional information
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| Size range | 1367-1638 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | LACLA has a weird insertion not found in other polC. |