HAMAP logo

HAMAP rule MF_00361

Send feedback

General rule information [?]

Accession MF_00361
Dates 1-JUN-2001 (Created)
17-JAN-2023 (Last updated, Version 32)
Name NAD_kinase
Scope
Bacteria
Archaea
Templates O30297 (NADK_ARCFU); Q8Y8D7 (NADK1_LISMO); P9WHV7 (NADK_MYCTU); P0A7B3 (NADK_ECOLI); O58801 (NADK_PYRHO); O31612 (NADK1_BACSU); P65774 (NADK_SALTY); Q58327 (NPPNK_METJA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NADK
Protein name
RecName: Full=NAD kinase;
EC 2.7.1.23;
AltName: Full=ATP-dependent NAD kinase;
Gene name
nadK

Comments [?]

Function Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalytic activity RHEA:18629: ATP + NAD(+) = ADP + H(+) + NADP(+)
EC 2.7.1.23
Cofactor a divalent metal cation
Subcellular location Cytoplasm.
Similarity Belongs to the NAD kinase family.

Keywords [?]

ATP-binding
Cytoplasm
Kinase
NAD
NADP
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0003951; Molecular function: NAD+ kinase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0005737; Cellular component: cytoplasm.
GO:0006741; Biological process: NADP biosynthetic process.

Cross-references [?]

Pfam PF01513; NAD_kinase; 1;

Features [?]

From: NADK_ARCFU (O30297)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     49     50       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [DN]-[GA]  
BINDING     115     116       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [NDE]-[ED]  
BINDING     156     161       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [TS]-x-[YHW]-x-x-S  
ACT_SITE     49     49       Proton acceptor     [DN]  
BINDING     54     54       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [RKH]  
BINDING     126     126       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [KHR]  
BINDING     143     143       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [RKH]  
BINDING     145     145       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [DN]  
BINDING     153     153       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [ILVA]  
BINDING     180     180       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [ALV]  
BINDING     211     211       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [QN]  

Additional information [?]

Size range 248-363 amino acids
Related rules None
Fusion Nter: <Inositol_P>; Cter: None


View rule in raw text format (no links)