HAMAP rule MF_00361

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00361
Accession	MF_00361
Dates	28-FEB-2005 (Created) 12-JUN-2025 (Last updated, Version 26)
Name	NAD_kinase
Scope(s)	Bacteria Archaea
Template(s)	O30297; Q8Y8D7; P9WHV7; P0A7B3; O58801; O31612; P65774; Q58327; [ Recover all ]
Triggered by	HAMAP; MF_00361 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NADK
Protein name	RecName: Full=NAD kinase; EC=2.7.1.23; AltName: Full=ATP-dependent NAD kinase;
Gene name	Name=nadK;

Comments [?]

FUNCTION	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
CATALYTIC ACTIVITY	Reaction=NAD(+) + ATP = ADP + NADP(+) + H(+); Xref=Rhea:RHEA:18629, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540, ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=2.7.1.23;
COFACTOR	Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the NAD kinase family.

Keywords [?]

Gene Ontology [?]

GO:0003951; Molecular function:NAD+ kinase activity

GO:0046872; Molecular function:metal ion binding

GO:0005737; Cellular component:cytoplasm

GO:0006741; Biological process:NADP+ biosynthetic process

Cross-references [?]

Pfam	PF01513; NAD_kinase; 1;

Features [?]

From: NADK_ARCFU (O30297)

Key

From

Description

Tag

Condition

FTGroup

BINDING