HAMAP logo

HAMAP rule MF_00361

Send feedback

General rule information [?]

Accession MF_00361
Dates 1-JUN-2001 (Created)
17-JAN-2023 (Last updated, Version 32)
Name NAD_kinase
Scope(s) Bacteria
Template(s) O30297 (NADK_ARCFU); Q8Y8D7 (NADK1_LISMO); P9WHV7 (NADK_MYCTU); P0A7B3 (NADK_ECOLI); O58801 (NADK_PYRHO); O31612 (NADK1_BACSU); P65774 (NADK_SALTY); Q58327 (NPPNK_METJA); [ Recover all ]
Triggered by HAMAP; MF_00361 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NADK
Protein name RecName: Full=NAD kinase;
AltName: Full=ATP-dependent NAD kinase;
Gene name Name=nadK;

Comments [?]

FUNCTIONInvolved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
CATALYTIC ACTIVITY Reaction=ATP + NAD(+) = ADP + H(+) + NADP(+); Xref=Rhea:RHEA:18629, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540, ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=;
COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
SIMILARITYBelongs to the NAD kinase family.

Keywords [?]

Gene Ontology [?]

GO:0003951; Molecular function:NAD+ kinase activity
GO:0046872; Molecular function:metal ion binding
GO:0005737; Cellular component:cytoplasm
GO:0006741; Biological process:NADP biosynthetic process

Cross-references [?]

Pfam PF01513; NAD_kinase; 1;

Features [?]

From: NADK_ARCFU (O30297)
Key From To Description Tag Condition FTGroup
BINDING 49 50 /ligand="NAD(+)"
BINDING 115 116 /ligand="NAD(+)"
BINDING 156 161 /ligand="NAD(+)"
ACT_SITE 49 49 /note="Proton acceptor" [DN]
BINDING 54 54 /ligand="NAD(+)"
BINDING 126 126 /ligand="NAD(+)"
BINDING 143 143 /ligand="NAD(+)"
BINDING 145 145 /ligand="NAD(+)"
BINDING 153 153 /ligand="NAD(+)"
BINDING 180 180 /ligand="NAD(+)"
BINDING 211 211 /ligand="NAD(+)"

Additional information [?]

Size range 248-363 amino acids
Related rules None
Fusion Nter: <Inositol_P> Cter: None

View rule in raw text format (no links)