Home  |  Contact
Annotation rule MF_00367
Send feedback

General rule information [?]

Accession MF_00367
Dates 1-JUN-2001 (Created)
19-MAY-2020 (Last updated, Version 37)
Name GTPase_Era
Templates P06616 (ERA_ECOLI); O67800 (ERA_AQUAE); P37214 (ERA_STRMU); P42182 (ERA_BACSU); P0A3C4 (ERA_STRR6); Q5SM23 (ERA_THET8): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=GTPase Era;
Gene name

Comments [?]

Function An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
Subunit Monomer.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cytoplasm. Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
Subcellular location Cytoplasm. Cell inner membrane; Peripheral membrane protein.
end case
Similarity Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.

Keywords [?]

case <Feature:PS50823>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0070181; Molecular function: small ribosomal subunit rRNA binding.
GO:0042274; Biological process: ribosomal small subunit biogenesis.
GO:0005737; Cellular component: cytoplasm.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF07650; KH_2; 1;
PF01926; MMR_HSR1; 1;
TIGRFAMs TIGR00436; Era; 1;
TIGR00231; Small_GTP; 1;
PROSITE PS50823; KH_TYPE_2; 1; trigger=PRU00118;
PS51713; G_ERA; 1; trigger=PRU01050;

Features [?]

From: ERA_ECOLI (P06616)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     15     22       GTP     G-x-[PTA]-x-x-G-K-S  
NP_BIND     62     66       GTP     D-[TV]-P-G-x  
NP_BIND     124     127       GTP     x-K-x-x  

Additional information [?]

Size range 278-325 amino acids
Related rules None
Fusion None
Comments RICCN has an RPE1 insert in its N-terminus and so is considered atypical.