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HAMAP rule MF_00367

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General rule information [?]

Accession MF_00367
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name GTPase_Era
Scope(s) Bacteria
Template(s) P06616 (ERA_ECOLI); O67800 (ERA_AQUAE); P37214 (ERA_STRMU); P42182 (ERA_BACSU); P0A3C4 (ERA_STRR6); Q5SM23 (ERA_THET8); A5U557 (ERA_MYCTA); A0R0S7 (ERA_MYCS2); [ Recover all ]
Triggered by HAMAP; MF_00367 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ERA
Protein name RecName: Full=GTPase Era;
Gene name Name=era;

Comments [?]

case not <OC:Mycobacteriaceae>
FUNCTIONAn essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
else case <OC:Mycobacteriaceae>
FUNCTIONExhibits GTPase activity. Binds RNA but is probably not involved in ribosome assembly in mycobacteria.
end case
case <OC:Mycobacteriaceae>
SUBCELLULAR LOCATIONCell envelope. Secreted, cell wall.
else case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCytoplasm. Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCytoplasm. Cell inner membrane; Peripheral membrane protein.
end case
SIMILARITYBelongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.

Keywords [?]

case not <OC:Mycobacteriaceae>
Cell membrane
Ribosome biogenesis
end case
case (defined <Property:Membrane> and <Property:Membrane=2>) and not <OC:Mycobacteriaceae>
Cell inner membrane
end case
case <OC:Mycobacteriaceae>
Cell wall
end case

Gene Ontology [?]

GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
case not <OCellular component:Mycobacteriaceae>
GO:0070181; Molecular function:small ribosomal subunit rRNA binding
GO:0042274; Biological process:ribosomal small subunit biogenesis
GO:0005737; Cellular component:cytoplasm
GO:0005886; Cellular component:plasma membrane
end case

Cross-references [?]

Pfam PF07650; KH_2; 1;
Pfam PF01926; MMR_HSR1; 1;
NCBIfam TIGR00436; Era; 1;
NCBIfam TIGR00231; Small_GTP; 1;
PROSITE PS50823; KH_TYPE_2; 1;
PROSITE PS51713; G_ERA; 1;

Features [?]

From: ERA_ECOLI (P06616)
Key From To Description Tag Condition FTGroup
BINDING 15 22 /ligand="GTP"
BINDING 62 66 /ligand="GTP"
BINDING 124 127 /ligand="GTP"

Additional information [?]

Size range 278-325 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments RICCN has an RPE1 insert in its N-terminus and so is considered atypical.

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