HAMAP logo

HAMAP rule MF_00367

Send feedback

General rule information [?]

Accession MF_00367
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41)
Name GTPase_Era
Templates P06616 (ERA_ECOLI); O67800 (ERA_AQUAE); P37214 (ERA_STRMU); P42182 (ERA_BACSU); P0A3C4 (ERA_STRR6); Q5SM23 (ERA_THET8); A5U557 (ERA_MYCTA); A0R0S7 (ERA_MYCS2): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=GTPase Era;
Gene name

Comments [?]

case not <OC:Mycobacteriaceae>
Function An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
else case <OC:Mycobacteriaceae>
Function Exhibits GTPase activity. Binds RNA but is probably not involved in ribosome assembly in mycobacteria.
end case
Subunit Monomer.
case <OC:Mycobacteriaceae>
Subcellular location Cell envelope. Secreted, cell wall.
else case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cytoplasm. Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
Subcellular location Cytoplasm. Cell inner membrane; Peripheral membrane protein.
end case
Similarity Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.

Keywords [?]

case not <OC:Mycobacteriaceae>
end case
case (defined <Property:Membrane> and <Property:Membrane=2>) and not <OC:Mycobacteriaceae>
end case
case <OC:Mycobacteriaceae>
end case

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
case not <OC:Mycobacteriaceae>
GO:0070181; Molecular function: small ribosomal subunit rRNA binding.
GO:0042274; Biological process: ribosomal small subunit biogenesis.
GO:0005737; Cellular component: cytoplasm.
GO:0005886; Cellular component: plasma membrane.
end case

Cross-references [?]

Pfam PF07650; KH_2; 1;
PF01926; MMR_HSR1; 1;
NCBIfam TIGR00436; Era; 1;
TIGR00231; Small_GTP; 1;
PROSITE PS50823; KH_TYPE_2; 1; trigger=PRU00118;
PS51713; G_ERA; 1; trigger=PRU01050;

Features [?]

From: ERA_ECOLI (P06616)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     15     22       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     G-x-[PTA]-x-x-G-K-S  
BINDING     62     66       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-[TV]-P-G-x  
BINDING     124     127       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     x-K-x-x  

Additional information [?]

Size range 278-325 amino acids
Related rules None
Fusion None
Comments RICCN has an RPE1 insert in its N-terminus and so is considered atypical.