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Annotation rule MF_00376
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General rule information [?]

Accession MF_00376
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 36)
Name Dephospho_CoA_kinase
Scope
Bacteria
Templates P0A6I9 (COAE_ECOLI); P9WPA3 (COAE_MYCTU); Q56416 (COAE_THET8): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COAE
Protein name
RecName: Full=Dephospho-CoA kinase;
EC 2.7.1.24;
AltName: Full=Dephosphocoenzyme A kinase;
Gene name
coaE

Comments [?]

Function Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Catalytic activity RHEA:18245: 3'-dephospho-CoA + ATP = ADP + CoA + H(+)
EC 2.7.1.24
Pathway Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.
Subcellular location Cytoplasm.
case <Feature:PF04229>
Domain The C-terminal UPF0157 domain is involved in the proper folding of the full length enzyme.
end case
Similarity Belongs to the CoaE family.

Keywords [?]

Cytoplasm
Transferase
Kinase
ATP-binding
Nucleotide-binding
Coenzyme A biosynthesis

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004140; Molecular function: dephospho-CoA kinase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01121; CoaE; 1;
PF04229; GrpB; 0-1;
TIGRFAMs TIGR00152; TIGR00152; 1;
PROSITE PS51219; DPCK; 1; trigger=PRU00564;

Features [?]

From: COAE_ECOLI (P0A6I9)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     12     17       ATP     [GASC]-x-G-K-[STDN]-x  

Additional information [?]

Size range 150-300 amino acids
Related rules None
Fusion Nter: None; Cter: <UPF0157>
Comments The UPF0157 (GrpB) C-terminal domain present in some species is probably involved in the folding of the protein. Natural frameshift reported in NEIMB.


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