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Annotation rule MF_00376 |
Accession | MF_00376 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 36) |
Name | Dephospho_CoA_kinase |
Scope | Bacteria |
Templates | P0A6I9 (COAE_ECOLI); P9WPA3 (COAE_MYCTU); Q56416 (COAE_THET8): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. |
Catalytic activity | RHEA:18245: 3'-dephospho-CoA + ATP = ADP + CoA + H(+)
EC 2.7.1.24 |
Pathway | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. |
Subcellular location | Cytoplasm. |
Domain | The C-terminal UPF0157 domain is involved in the proper folding of the full length enzyme. |
Similarity | Belongs to the CoaE family. |
Pfam | PF01121; CoaE; 1; |
PF04229; GrpB; 0-1; | |
TIGRFAMs | TIGR00152; TIGR00152; 1; |
PROSITE | PS51219; DPCK; 1; trigger=PRU00564; |
From: COAE_ECOLI (P0A6I9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 12 | 17 | ATP | [GASC]-x-G-K-[STDN]-x |
Size range | 150-300 amino acids |
Related rules | None |
Fusion | Nter: None; Cter: <UPF0157> |
Comments | The UPF0157 (GrpB) C-terminal domain present in some species is probably involved in the folding of the protein. Natural frameshift reported in NEIMB. |