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HAMAP rule MF_00376

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General rule information [?]

Accession MF_00376
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 39)
Name Dephospho_CoA_kinase
Scope(s) Bacteria
Template(s) P0A6I9 (COAE_ECOLI); P9WPA3 (COAE_MYCTU); Q56416 (COAE_THET8); [ Recover all ]
Triggered by HAMAP; MF_00376 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier COAE
Protein name RecName: Full=Dephospho-CoA kinase;
AltName: Full=Dephosphocoenzyme A kinase;
Gene name Name=coaE;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
CATALYTIC ACTIVITY Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+); Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216; EC=;
PATHWAYCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 5/5.
case <Feature:PF04229>
DOMAINThe C-terminal UPF0157 domain is involved in the proper folding of the full length enzyme.
end case
SIMILARITYBelongs to the CoaE family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004140; Molecular function:dephospho-CoA kinase activity
GO:0015937; Biological process:coenzyme A biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01121; CoaE; 1;
Pfam PF04229; GrpB; 0-1;
NCBIfam TIGR00152; TIGR00152; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 12 17 /ligand="ATP"

Additional information [?]

Size range 150-300 amino acids
Related rules None
Fusion Nter: None Cter: <UPF0157>
Comments The UPF0157 (GrpB) C-terminal domain present in some species is probably involved in the folding of the protein. Natural frameshift reported in NEIMB.

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