HAMAP rule MF_00377
General rule information
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| Accession | MF_00377 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 34) |
| Name | DnaA_bact |
| Scope(s) |
Bacteria |
| Template(s) | P03004 (DNAA_ECOLI); P05648 (DNAA_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00377 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DNAA |
| Protein name | RecName: Full=Chromosomal replication initiator protein DnaA; |
| Gene name | Name=dnaA; |
Comments
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| FUNCTION | Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the DnaA family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0003688; Molecular function:DNA replication origin binding |
| GO:0006270; Biological process:DNA replication initiation |
| GO:0006275; Biological process:regulation of DNA replication |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00308; Bac_DnaA; 1; |
| Pfam | PF08299; Bac_DnaA_C; 1; |
| PRINTS | PR00051; DNAA; 1; |
| NCBIfam | TIGR00362; DnaA; 1; |
| PROSITE | PS01008; DNAA; 1; |
Features
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| From: DNAA_ECOLI (P03004) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 172 | 179 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GSA]-x(2)-[GS]-x-G-K-[ST] | ||||||||
Additional information
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| Size range | 399-656 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |