HAMAP rule MF_00377
General rule information
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| Accession | MF_00377 |
| Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 33) |
| Name | DnaA_bact |
| Scope | Bacteria |
| Templates | P03004 (DNAA_ECOLI); P05648 (DNAA_BACSU): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the DnaA family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0003688; Molecular function: DNA replication origin binding.
GO:0006270; Biological process: DNA replication initiation.
GO:0006275; Biological process: regulation of DNA replication.
GO:0005737; Cellular component: cytoplasm.
GO:0003688; Molecular function: DNA replication origin binding.
GO:0006270; Biological process: DNA replication initiation.
GO:0006275; Biological process: regulation of DNA replication.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00308; Bac_DnaA; 1; |
| PF08299; Bac_DnaA_C; 1; | |
| PRINTS | PR00051; DNAA; 1; |
| TIGRFAMs | TIGR00362; DnaA; 1; |
| PROSITE | PS01008; DNAA; 1; |
Features
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| From: DNAA_ECOLI (P03004) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 172 | 179 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [GSA]-x(2)-[GS]-x-G-K-[ST] | ||||||||
Additional information
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| Size range | 399-656 amino acids |
| Related rules | None |
| Fusion | None |