HAMAP rule MF_00383
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00383 |
| Accession | MF_00383 |
| Dates | 28-FEB-2005 (Created)
19-NOV-2022 (Last updated, Version 30) |
| Name | TF2B_arch |
| Scope(s) |
Archaea |
| Template(s) | P61998; P61999; [ Recover all ] |
| Triggered by |
HAMAP; MF_00383 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TF2B |
| Protein name | RecName: Full=Transcription initiation factor IIB; Short=TFIIB; |
| Gene name | Name=tfb; |
Comments
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| FUNCTION | Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). |
| SIMILARITY | Belongs to the TFIIB family. |
Keywords
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| Transcription | |
| Transcription regulation | |
| Repeat | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0003700; Molecular function:DNA-binding transcription factor activity | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0006355; Biological process:regulation of DNA-templated transcription | |
| GO:0006352; Biological process:DNA-templated transcription initiation | |
Cross-references
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| Pfam | PF00382; TFIIB; 2; |
| Pfam | PF08271; TF_Zn_Ribbon; 1; |
| PRINTS | PR00685; TIFACTORIIB; 1; |
| PROSITE | PS00782; TFIIB; 2; |
| PROSITE | PS51134; ZF_TFIIB; 0-1; |
Features
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| From: TF2B_PYRFU (P61998) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | 114 | 197 | /note="1" | |||||||||
| REPEAT | 210 | 291 | /note="2" | |||||||||
| BINDING | 7 | 7 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 10 | 10 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 26 | 26 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 29 | 29 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 287-339 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Intein deleted in METJA |