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HAMAP rule MF_00387

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General rule information [?]

Accession MF_00387
Dates 1-JUN-2001 (Created)
9-JUN-2021 (Last updated, Version 35)
Name LpxA
Scope
Bacteria
Plastid
Templates P0A722 (LPXA_ECOLI); P32199 (LPXA_RICRI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LPXA
Protein name
RecName: Full=Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase;
Short=UDP-N-acetylglucosamine acyltransferase;
EC 2.3.1.129;
Gene name
lpxA

Comments [?]

case not <OG:Chloroplast>
Function Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
end case
case <OG:Chloroplast>
Function Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane.
end case
Catalytic activity RHEA:67812: a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]
EC 2.3.1.129
Pathway Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6.
Subunit Homotrimer.
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
else
Subcellular location Cytoplasm.
end case
Similarity Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Keywords [?]

case not <OG:Chloroplast>
Cytoplasm
end case
Acyltransferase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Repeat
Transferase

Gene Ontology [?]

GO:0008780; Molecular function: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
else
GO:0005737; Cellular component: cytoplasm.
end case

Cross-references [?]

Pfam PF00132; Hexapep; 5-8;
PIRSF PIRSF000456; UDP-GlcNAc_acltr; 1;
TIGRFAMs TIGR01852; Lipid_A_lpxA; 1;
PROSITE PS00101; HEXAPEP_TRANSFERASES; 1;

Additional information [?]

Size range 257-283 amino acids
Related rules MF_00523 (LPXD)
Fusion None


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