HAMAP rule MF_00387
General rule information
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| Accession | MF_00387 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 36) |
| Name | LpxA |
| Scope(s) |
Bacteria Plastid |
| Template(s) | P0A722 (LPXA_ECOLI); P32199 (LPXA_RICRI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00387 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LPXA |
| Protein name | RecName: Full=Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Short=UDP-N-acetylglucosamine acyltransferase; EC=2.3.1.129; |
| Gene name | Name=lpxA; |
Comments
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| case not <OG:Chloroplast> | |
| FUNCTION | Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
| end case | |
| case <OG:Chloroplast> | |
| FUNCTION | Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo- [ACP]; Xref=Rhea:RHEA:67812, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:9945, ChEBI:CHEBI:57705, ChEBI:CHEBI:64479, ChEBI:CHEBI:78827, ChEBI:CHEBI:173225; EC=2.3.1.129; |
| PATHWAY | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 1/6. |
| SUBUNIT | Homotrimer. |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the transferase hexapeptide repeat family. LpxA subfamily. |
Keywords
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| case not <OG:Chloroplast> | |
| Cytoplasm | |
| end case | |
| Acyltransferase | |
| Lipid A biosynthesis | |
| Lipid biosynthesis | |
| Lipid metabolism | |
| Repeat | |
| Transferase | |
Gene Ontology
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| GO:0008780; Molecular function:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity | |
| GO:0009245; Biological process:lipid A biosynthetic process | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
Cross-references
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| Pfam | PF00132; Hexapep; 5-8; |
| PIRSF | PIRSF000456; UDP-GlcNAc_acltr; 1; |
| NCBIfam | TIGR01852; Lipid_A_lpxA; 1; |
| PROSITE | PS00101; HEXAPEP_TRANSFERASES; 1; |
Features
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Additional information
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| Size range | 257-283 amino acids |
| Related rules |
MF_00523 |
| Fusion | Nter: None Cter: None |