HAMAP rule MF_00387
General rule information
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Accession | MF_00387 |
Dates | 1-JUN-2001 (Created) 9-JUN-2021 (Last updated, Version 35) |
Name | LpxA |
Scope | Bacteria
Plastid |
Templates | P0A722 (LPXA_ECOLI); P32199 (LPXA_RICRI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
Gene name |
|
Comments
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case not <OG:Chloroplast>
Function | Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
end case
case <OG:Chloroplast>
Function | Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane. |
end case
Catalytic activity | RHEA:67812: a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]
EC 2.3.1.129 |
Pathway | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. |
Subunit | Homotrimer. |
case <OG:Chloroplast>
Subcellular location | Plastid, chloroplast. |
else
Subcellular location | Cytoplasm. |
end case
Similarity | Belongs to the transferase hexapeptide repeat family. LpxA subfamily. |
Keywords
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case not <OG:Chloroplast>
end case
Gene Ontology
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GO:0008780; Molecular function: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0009245; Biological process: lipid A biosynthetic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
else
GO:0005737; Cellular component: cytoplasm.
end case
Cross-references
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Pfam | PF00132; Hexapep; 5-8; |
PIRSF | PIRSF000456; UDP-GlcNAc_acltr; 1; |
TIGRFAMs | TIGR01852; Lipid_A_lpxA; 1; |
PROSITE | PS00101; HEXAPEP_TRANSFERASES; 1; |
Additional information
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Size range | 257-283 amino acids |
Related rules | MF_00523 (LPXD) |
Fusion | None |