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HAMAP rule MF_00392

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General rule information [?]

Accession MF_00392
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 28)
Name LpxB
Scope(s) Bacteria
Template(s) P10441 (LPXB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00392 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LPXB
Protein name RecName: Full=Lipid-A-disaccharide synthase;
Gene name Name=lpxB;

Comments [?]

FUNCTIONCondensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
case <OC:Enterobacterales>
CATALYTIC ACTIVITY Reaction=2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D- glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP; Xref=Rhea:RHEA:22668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57957, ChEBI:CHEBI:58223, ChEBI:CHEBI:58466, ChEBI:CHEBI:78847;
end case
CATALYTIC ACTIVITY Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D- glucosamine = a lipid A disaccharide + H(+) + UDP; Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343; EC=;
case <OC:Enterobacterales>
PATHWAYGlycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 5/6.
PATHWAYBacterial outer membrane biogenesis; LPS lipid A biosynthesis.
end case
SIMILARITYBelongs to the LpxB family.

Keywords [?]

Gene Ontology [?]

GO:0008915; Molecular function:lipid-A-disaccharide synthase activity
GO:0009245; Biological process:lipid A biosynthetic process

Cross-references [?]

Pfam PF02684; LpxB; 1;
NCBIfam TIGR00215; LpxB; 1;

Features [?]

Additional information [?]

Size range 356-439 amino acids
Related rules None
Fusion Nter: <Unknown> Cter: None
Comments Unknown N-terminal domain in Chlamydiaceae. Possible wrong start in XANAC.

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