HAMAP rule MF_00392

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00392
Accession	MF_00392
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 22)
Name	LpxB
Scope(s)	Bacteria
Template(s)	P10441; [ Recover all ]
Triggered by	HAMAP; MF_00392 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LPXB
Protein name	RecName: Full=Lipid-A-disaccharide synthase; EC=2.4.1.182;
Gene name	Name=lpxB;

Comments [?]

FUNCTION	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
case <OC:Enterobacterales>
CATALYTIC ACTIVITY	Reaction=2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D- glucosamine = lipid A disaccharide (E. coli) + UDP + H(+); Xref=Rhea:RHEA:22668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57957, ChEBI:CHEBI:58223, ChEBI:CHEBI:58466, ChEBI:CHEBI:78847;
end case
CATALYTIC ACTIVITY	Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D- glucosamine = a lipid A disaccharide + UDP + H(+); Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343; EC=2.4.1.182;
case <OC:Enterobacterales>
PATHWAY	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 5/6.
else
PATHWAY	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
end case
SIMILARITY	Belongs to the LpxB family.

Keywords [?]

Gene Ontology [?]

GO:0008915; Molecular function:lipid-A-disaccharide synthase activity

GO:0009245; Biological process:lipid A biosynthetic process

Cross-references [?]

Pfam	PF02684; LpxB; 1;
NCBIfam	TIGR00215; LpxB; 1;

Features [?]

Additional information [?]

Size range	356-439 amino acids
Related rules	None
Fusion	Nter: <Unknown> Cter: None
Comments	Unknown N-terminal domain in Chlamydiaceae. Possible wrong start in XANAC.