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| Annotation rule MF_00392 |
General rule information
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| Accession | MF_00392 |
| Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 25) |
| Name | LpxB |
| Scope | Bacteria |
| Template | P10441 (LPXB_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
| Catalytic activity | RHEA:22668: 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP
EC 2.4.1.182 |
| Pathway | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. |
| Similarity | Belongs to the LpxB family. |
Keywords
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Gene Ontology
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GO:0008915; Molecular function: lipid-A-disaccharide synthase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0009245; Biological process: lipid A biosynthetic process.
Cross-references
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Additional information
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| Size range | 356-439 amino acids |
| Related rules | None |
| Fusion | Nter: <Unknown>; Cter: None |
| Comments | Unknown N-terminal domain in Chlamydiaceae. Possible wrong start in XANAC. |