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HAMAP rule MF_00392

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General rule information [?]

Accession MF_00392
Dates 1-JUN-2001 (Created)
23-AUG-2021 (Last updated, Version 27)
Name LpxB
Scope
Bacteria
Template P10441 (LPXB_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LPXB
Protein name
RecName: Full=Lipid-A-disaccharide synthase;
EC 2.4.1.182;
Gene name
lpxB

Comments [?]

Function Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
case <OC:Enterobacterales>
Catalytic activity RHEA:22668: 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP
end case
Catalytic activity RHEA:67828: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP
EC 2.4.1.182
case <OC:Enterobacterales>
Pathway Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6.
else
Pathway Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
end case
Similarity Belongs to the LpxB family.

Keywords [?]

Glycosyltransferase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Transferase

Gene Ontology [?]

GO:0008915; Molecular function: lipid-A-disaccharide synthase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

Cross-references [?]

Pfam PF02684; LpxB; 1;
TIGRFAMs TIGR00215; LpxB; 1;

Additional information [?]

Size range 356-439 amino acids
Related rules None
Fusion Nter: <Unknown>; Cter: None
Comments Unknown N-terminal domain in Chlamydiaceae. Possible wrong start in XANAC.


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