HAMAP rule MF_00392
General rule information
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Accession | MF_00392 |
Dates | 1-JUN-2001 (Created) 23-AUG-2021 (Last updated, Version 27) |
Name | LpxB |
Scope | Bacteria |
Template | P10441 (LPXB_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
case <OC:Enterobacterales>
Catalytic activity | RHEA:22668: 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP |
end case
Catalytic activity | RHEA:67828: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP
EC 2.4.1.182 |
case <OC:Enterobacterales>
Pathway | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. |
else
Pathway | Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. |
end case
Similarity | Belongs to the LpxB family. |
Keywords
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Gene Ontology
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GO:0008915; Molecular function: lipid-A-disaccharide synthase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0009245; Biological process: lipid A biosynthetic process.
Cross-references
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Additional information
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Size range | 356-439 amino acids |
Related rules | None |
Fusion | Nter: <Unknown>; Cter: None |
Comments | Unknown N-terminal domain in Chlamydiaceae. Possible wrong start in XANAC. |