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|
| Annotation rule MF_00392 |
General rule information
[?]
| Accession |
MF_00392 |
| Dates |
1-JUN-2001 (Created)
23-AUG-2021 (Last updated, Version 27) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Function |
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
case <OC:Enterobacterales>
| Catalytic activity |
RHEA:22668: 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP
|
end case
| Catalytic activity |
RHEA:67828: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP
EC 2.4.1.182
|
case <OC:Enterobacterales>
| Pathway |
Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. |
else
| Pathway |
Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. |
end case
| Similarity |
Belongs to the LpxB family. |
GO:0008915; Molecular function: lipid-A-disaccharide synthase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
Additional information
[?]
| Size range |
356-439 amino acids |
| Related rules |
None |
| Fusion |
Nter: <Unknown>; Cter: None |
| Comments |
Unknown N-terminal domain in Chlamydiaceae. Possible wrong start in XANAC. |