HAMAP rule MF_00393
General rule information
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| Accession | MF_00393 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | Glyc3P_acyltrans |
| Scope(s) |
Bacteria |
| Template(s) | P0A7A7 (PLSB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00393 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PLSB |
| Protein name | RecName: Full=Glycerol-3-phosphate acyltransferase; Short=GPAT; EC=2.3.1.15; |
| Gene name | Name=plsB; |
Comments
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| CATALYTIC ACTIVITY | Reaction=an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:15325, ChEBI:CHEBI:57287, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342; EC=2.3.1.15; |
| PATHWAY | Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- diacylglycerol from sn-glycerol 3-phosphate: step 1/3. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. |
| end case | |
| DOMAIN | The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. |
| SIMILARITY | Belongs to the GPAT/DAPAT family. |
Keywords
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| Acyltransferase | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Lipid biosynthesis | |
| Lipid metabolism | |
| Membrane | |
| Phospholipid biosynthesis | |
| Phospholipid metabolism | |
| Transferase | |
Gene Ontology
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| GO:0004366; Molecular function:glycerol-3-phosphate O-acyltransferase activity |
| GO:0008654; Biological process:phospholipid biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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Features
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| From: PLSB_ECOLI (P0A7A7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 305 | 310 | /note="HXXXXD motif" | |||||||||
Additional information
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| Size range | 775-886 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in XANAC, XANCP and XYLFA. Second divergent plsB in MYCTU; not shown in alignment. |