HAMAP logo

HAMAP rule MF_00393

Send feedback

General rule information [?]

Accession MF_00393
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name Glyc3P_acyltrans
Scope
Bacteria
Template P0A7A7 (PLSB_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PLSB
Protein name
RecName: Full=Glycerol-3-phosphate acyltransferase;
Short=GPAT;
EC 2.3.1.15;
Gene name
plsB

Comments [?]

Catalytic activity RHEA:15325: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA
EC 2.3.1.15
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein; Cytoplasmic side.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
end case
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Similarity Belongs to the GPAT/DAPAT family.

Keywords [?]

Acyltransferase
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Lipid biosynthesis
Lipid metabolism
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Transferase

Gene Ontology [?]

GO:0004366; Molecular function: glycerol-3-phosphate O-acyltransferase activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01553; Acyltransferase; 1;
NCBIfam TIGR03703; plsB; 1;

Features [?]

From: PLSB_ECOLI (P0A7A7)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     305     310       HXXXXD motif        

Additional information [?]

Size range 775-886 amino acids
Related rules None
Fusion None
Comments Possible wrong start in XANAC, XANCP and XYLFA. Second divergent plsB in MYCTU; not shown in alignment.


View rule in raw text format (no links)