HAMAP rule MF_00399
General rule information
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| Accession | MF_00399 |
| Dates | 1-JUN-2001 (Created) 28-JAN-2022 (Last updated, Version 43) |
| Name | DbsD |
| Scope | Bacteria |
| Template | P36655 (DSBD_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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case <Feature:Signal>
| Protein name |
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end case
| Gene name |
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Comments
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| Function | Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. |
| Catalytic activity | RHEA:18749: [protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH
EC 1.8.1.8 |
| RHEA:18753: [protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH
EC 1.8.1.8 |
|
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
| Similarity | Belongs to the thioredoxin family. DsbD subfamily. |
Keywords
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Cell inner membrane
Cell membrane
Cytochrome c-type biogenesis
Disulfide bond
Electron transport
Membrane
NAD
Oxidoreductase
Redox-active center
Cell membrane
Cytochrome c-type biogenesis
Disulfide bond
Electron transport
Membrane
NAD
Oxidoreductase
Redox-active center
case <Feature:Signal>
end case
Gene Ontology
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GO:0009055; Molecular function: electron transfer activity.
GO:0047134; Molecular function: protein-disulfide reductase (NAD(P)) activity.
GO:0017004; Biological process: cytochrome complex assembly.
GO:0005886; Cellular component: plasma membrane.
GO:0047134; Molecular function: protein-disulfide reductase (NAD(P)) activity.
GO:0017004; Biological process: cytochrome complex assembly.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| Pfam | PF02683; DsbD; 1; |
| PF00085; Thioredoxin; 1; | |
| PRINTS | PR00421; THIOREDOXIN; 1; |
| PROSITE | PS00194; THIOREDOXIN_1; 1; |
| PS51352; THIOREDOXIN_2; 1; trigger=PRU00691; |
Computed features
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| General | Signal; -; 1; trigger=yes; |
| Transmembrane; -; 7-9; trigger=yes; |
Features
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| From: DSBD_ECOLI (P36655) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 122 | 128 | Redox-active | C-x(4,5)-C | ||||||||
| DISULFID | 182 | 304 | Redox-active | C-x*-C | ||||||||
| DISULFID | 480 | 483 | Redox-active | C-x(2)-C | ||||||||
Additional information
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| Size range | 565-608 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Possible wrong start in RALSO |