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HAMAP rule MF_00399

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General rule information [?]

Accession MF_00399
Dates 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 44)
Name DbsD
Scope(s) Bacteria
Template(s) P36655 (DSBD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00399 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DSBD
Protein name RecName: Full=Thiol:disulfide interchange protein DsbD;
AltName: Full=Protein-disulfide reductase;
                 Short=Disulfide reductase;
case <Feature:Signal>
Protein name + Flags: Precursor;
end case
Gene name Name=dsbD;

Comments [?]

FUNCTIONRequired to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
CATALYTIC ACTIVITY Reaction=[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH; Xref=Rhea:RHEA:18749, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
CATALYTIC ACTIVITY Reaction=[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:18753, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=;
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the thioredoxin family. DsbD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0009055; Molecular function:electron transfer activity
GO:0047134; Molecular function:protein-disulfide reductase (NAD(P)) activity
GO:0017004; Biological process:cytochrome complex assembly
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF02683; DsbD; 1;
Pfam PF00085; Thioredoxin; 1;
General Signal; -; 1;
General Transmembrane; -; 7-9;

Features [?]

From: DSBD_ECOLI (P36655)
Key From To Description Tag Condition FTGroup
DISULFID 122 128 /note="Redox-active" C-x(4,5)-C
DISULFID 182 304 /note="Redox-active" C-x*-C
DISULFID 480 483 /note="Redox-active" C-x(2)-C

Additional information [?]

Size range 565-608 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong start in RALN1

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