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Annotation rule MF_00399
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General rule information [?]

Accession MF_00399
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 40)
Name DbsD
Scope
Bacteria
Template P36655 (DSBD_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DSBD
Protein name
RecName: Full=Thiol:disulfide interchange protein DsbD;
EC 1.8.1.8;
AltName: Full=Protein-disulfide reductase;
Short=Disulfide reductase;
Flags: Precursor;
Gene name
dsbD

Comments [?]

Function Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
Catalytic activity RHEA:18749: [protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH
EC 1.8.1.8
RHEA:18753: [protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH
EC 1.8.1.8
Subcellular location Cell inner membrane; Multi-pass membrane protein.
Similarity Belongs to the thioredoxin family. DsbD subfamily.

Keywords [?]


Gene Ontology [?]

GO:0009055; Molecular function: electron transfer activity.
GO:0047134; Molecular function: protein-disulfide reductase activity.
GO:0017004; Biological process: cytochrome complex assembly.
GO:0055114; Biological process: oxidation-reduction process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02683; DsbD; 1;
PF00085; Thioredoxin; 1;
PRINTS PR00421; THIOREDOXIN; 1;
PROSITE PS00194; THIOREDOXIN_1; 1;
PS51352; THIOREDOXIN_2; 1; trigger=PRU00691;

Computed features [?]

General Signal; -; 1; trigger=yes;
Transmembrane; -; 7-9; trigger=yes;

Features [?]

From: DSBD_ECOLI (P36655)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     122     128       Redox-active     C-x(4,5)-C  
DISULFID     182     304       Redox-active     C-x*-C  
DISULFID     480     483       Redox-active     C-x(2)-C  

Additional information [?]

Size range 565-608 amino acids
Related rules None
Fusion None
Comments Possible wrong start in RALSO