HAMAP rule MF_00399
General rule information
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Accession | MF_00399 |
Dates | 1-JUN-2001 (Created)
25-APR-2024 (Last updated, Version 45) |
Name | DbsD |
Scope(s) |
Bacteria |
Template(s) | P36655 (DSBD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00399 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DSBD |
Protein name | RecName: Full=Thiol:disulfide interchange protein DsbD; EC=1.8.1.8; AltName: Full=Protein-disulfide reductase; Short=Disulfide reductase; |
case <Feature:Signal> | |
Protein name | + Flags: Precursor; |
end case | |
Gene name | Name=dsbD; |
Comments
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FUNCTION | Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. |
CATALYTIC ACTIVITY | Reaction=[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH; Xref=Rhea:RHEA:18749, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.8.1.8; |
CATALYTIC ACTIVITY | Reaction=[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:18753, Rhea:RHEA-COMP:10593, Rhea:RHEA- COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.8; |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
SIMILARITY | Belongs to the thioredoxin family. DsbD subfamily. |
Keywords
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Gene Ontology
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GO:0009055; Molecular function:electron transfer activity |
GO:0047134; Molecular function:protein-disulfide reductase (NAD(P)H) activity |
GO:0017004; Biological process:cytochrome complex assembly |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF02683; DsbD; 1; |
Pfam | PF00085; Thioredoxin; 1; |
PRINTS | PR00421; THIOREDOXIN; 1; |
PROSITE | PS00194; THIOREDOXIN_1; 1; |
PROSITE | PS51352; THIOREDOXIN_2; 1; |
General | Signal; -; 1; |
General | Transmembrane; -; 7-9; |
Features
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From: DSBD_ECOLI (P36655) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DISULFID | 122 | 128 | /note="Redox-active" | C-x(4,5)-C | ||||||||
DISULFID | 182 | 304 | /note="Redox-active" | C-x*-C | ||||||||
DISULFID | 480 | 483 | /note="Redox-active" | C-x(2)-C |
Additional information
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Size range | 565-608 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Possible wrong start in RALN1 |