HAMAP rule MF_00406
General rule information
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| Accession | MF_00406 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 31) |
| Name | FabZ |
| Scope(s) |
Bacteria |
| Template(s) | P0A6Q6 (FABZ_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00406 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FABZ |
| Protein name | RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; EC=4.2.1.59; AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Short=(3R)-hydroxymyristoyl-ACP dehydrase; AltName: Full=Beta-hydroxyacyl-ACP dehydratase; |
| Gene name | Name=fabZ; |
Comments
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| FUNCTION | Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. |
| CATALYTIC ACTIVITY | Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O; Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59; |
| case <OC:Escherichia> or <OC:Shigella> | |
| SUBUNIT | Oligomer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| case <OC:Escherichia> or <OC:Shigella> | |
| PTM | The N-terminus is blocked. |
| end case | |
| SIMILARITY | Belongs to the thioester dehydratase family. FabZ subfamily. |
Keywords
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Gene Ontology
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| GO:0016836; Molecular function:hydro-lyase activity |
| GO:0006633; Biological process:fatty acid biosynthetic process |
| GO:0009245; Biological process:lipid A biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: FABZ_ECOLI (P0A6Q6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 54 | 54 | H | |||||||||
Additional information
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| Size range | 132-181 amino acids |
| Related rules |
MF_00405 |
| Fusion | Nter: MF_00388 (lpxC) Cter: None |
| Comments | Possible wrong start in SYNY3 |