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Annotation rule MF_00406
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General rule information [?]

Accession MF_00406
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 30)
Name FabZ
Scope
Bacteria
Template P0A6Q6 (FABZ_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FABZ
Protein name
RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ;
EC 4.2.1.59;
AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase;
Short=(3R)-hydroxymyristoyl-ACP dehydrase;
AltName: Full=Beta-hydroxyacyl-ACP dehydratase;
Gene name
fabZ

Comments [?]

Function Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
Catalytic activity RHEA:13097: a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O
EC 4.2.1.59
case <OC:Escherichia> or <OC:Shigella>
Subunit Oligomer.
end case
Subcellular location Cytoplasm.
case <OC:Escherichia> or <OC:Shigella>
Ptm The N-terminus is blocked.
end case
Similarity Belongs to the thioester dehydratase family. FabZ subfamily.

Keywords [?]

Cytoplasm
Lyase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism

Gene Ontology [?]

GO:0016836; Molecular function: hydro-lyase activity.
GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF07977; FabA; 1;
TIGRFAMs TIGR01750; FabZ; 1;

Features [?]

From: FABZ_ECOLI (P0A6Q6)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     54     54             H  

Additional information [?]

Size range 132-181 amino acids
Related rules MF_00405 (FABA)
Fusion Nter: MF_00388 (lpxC); Cter: None
Comments Possible wrong start in SYNY3


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