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HAMAP rule MF_00406

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General rule information [?]

Accession MF_00406
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 31)
Name FabZ
Scope(s) Bacteria
Template(s) P0A6Q6 (FABZ_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00406 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FABZ
Protein name RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ;
AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase;
                 Short=(3R)-hydroxymyristoyl-ACP dehydrase;
AltName: Full=Beta-hydroxyacyl-ACP dehydratase;
Gene name Name=fabZ;

Comments [?]

FUNCTIONInvolved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
CATALYTIC ACTIVITY Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O; Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=;
case <OC:Escherichia> or <OC:Shigella>
end case
case <OC:Escherichia> or <OC:Shigella>
PTMThe N-terminus is blocked.
end case
SIMILARITYBelongs to the thioester dehydratase family. FabZ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016836; Molecular function:hydro-lyase activity
GO:0006633; Biological process:fatty acid biosynthetic process
GO:0009245; Biological process:lipid A biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF07977; FabA; 1;
NCBIfam TIGR01750; FabZ; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 54 54 H

Additional information [?]

Size range 132-181 amino acids
Related rules MF_00405
Fusion Nter: MF_00388 (lpxC) Cter: None
Comments Possible wrong start in SYNY3

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