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Annotation rule MF_00409
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General rule information [?]

Accession MF_00409
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 27)
Name LpxK
Scope
Bacteria
Template P27300 (LPXK_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LPXK
Protein name
RecName: Full=Tetraacyldisaccharide 4'-kinase;
EC 2.7.1.130;
AltName: Full=Lipid A 4'-kinase;
Gene name
lpxK

Comments [?]

Function Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Catalytic activity Reaction=ATP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-4-O-phospho-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl phosphate).; EC=2.7.1.130;
Pathway Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.
Similarity Belongs to the LpxK family.

Keywords [?]

ATP-binding
Kinase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0009029; Molecular function: tetraacyldisaccharide 4'-kinase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

Cross-references [?]

Pfam PF02606; LpxK; 1;
TIGRFAMs TIGR00682; LpxK; 1;

Features [?]

From: LPXK_ECOLI (P27300)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     55     62       ATP     x(2)-G-G-x-G-K-T  

Additional information [?]

Size range 305-385 amino acids
Related rules None
Fusion Nter: None; Cter: MF_01187 (Ynnn)


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