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Annotation rule MF_00409 |
Accession | MF_00409 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 27) |
Name | LpxK |
Scope | Bacteria |
Template | P27300 (LPXK_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). |
Catalytic activity | Reaction=ATP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-4-O-phospho-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl phosphate).; EC=2.7.1.130; |
Pathway | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. |
Similarity | Belongs to the LpxK family. |
From: LPXK_ECOLI (P27300) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 55 | 62 | ATP | x(2)-G-G-x-G-K-T |
Size range | 305-385 amino acids |
Related rules | None |
Fusion | Nter: None; Cter: MF_01187 (Ynnn) |