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HAMAP rule MF_00409

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General rule information [?]

Accession MF_00409
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name LpxK
Scope(s) Bacteria
Template(s) P27300 (LPXK_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00409 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LPXK
Protein name RecName: Full=Tetraacyldisaccharide 4'-kinase;
AltName: Full=Lipid A 4'-kinase;
Gene name Name=lpxK;

Comments [?]

FUNCTIONTransfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
CATALYTIC ACTIVITY Reaction=a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+); Xref=Rhea:RHEA:67840, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:176343, ChEBI:CHEBI:176425, ChEBI:CHEBI:456216; EC=;
PATHWAYGlycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 6/6.
SIMILARITYBelongs to the LpxK family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0009029; Molecular function:tetraacyldisaccharide 4'-kinase activity
GO:0009245; Biological process:lipid A biosynthetic process

Cross-references [?]

Pfam PF02606; LpxK; 1;
NCBIfam TIGR00682; LpxK; 1;

Features [?]

From: LPXK_ECOLI (P27300)
Key From To Description Tag Condition FTGroup
BINDING 55 62 /ligand="ATP"

Additional information [?]

Size range 305-385 amino acids
Related rules None
Fusion Nter: None Cter: MF_01187 (Ynnn)

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