HAMAP rule MF_00413
General rule information
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| Accession | MF_00413 |
| Dates | 1-JUN-2001 (Created)
31-JAN-2024 (Last updated, Version 24) |
| Name | Thiourid_synth_A |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0A890 (TUSA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00413 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TUSA |
| case <OC:Enterobacterales> | |
| Protein name | RecName: Full=Sulfur carrier protein TusA; AltName: Full=Sulfur mediator TusA; AltName: Full=Sulfur transfer protein TusA; AltName: Full=tRNA 2-thiouridine synthesizing protein A; |
| else | |
| Protein name | RecName: Full=Sulfur carrier protein TusA; |
| end case | |
| Gene name | Name=tusA; |
Comments
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| case <OC:Enterobacterales> | |
| FUNCTION | Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin. |
| SUBUNIT | Interacts with IscS. |
| PATHWAY | tRNA modification. |
| else | |
| FUNCTION | Sulfur carrier protein which probably makes part of a sulfur- relay system. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the sulfur carrier protein TusA family. |
Keywords
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| Cytoplasm | |
| case <OC:Enterobacterales> | |
| tRNA processing | |
| end case | |
Gene Ontology
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| GO:0097163; Molecular function:sulfur carrier activity | |
| case <OCellular component:Enterobacterales> | |
| GO:0006400; Biological process:tRNA modification | |
| end case | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: TUSA_ECOLI (P0A890) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 19 | 19 | /note="Cysteine persulfide intermediate" | C | ||||||||
Additional information
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| Size range | 76-84 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |