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HAMAP rule MF_00413

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General rule information [?]

Accession MF_00413
Dates 1-JUN-2001 (Created)
31-JAN-2024 (Last updated, Version 24)
Name Thiourid_synth_A
Scope(s) Bacteria
Template(s) P0A890 (TUSA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00413 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TUSA
case <OC:Enterobacterales>
Protein name RecName: Full=Sulfur carrier protein TusA;
AltName: Full=Sulfur mediator TusA;
AltName: Full=Sulfur transfer protein TusA;
AltName: Full=tRNA 2-thiouridine synthesizing protein A;
Protein name RecName: Full=Sulfur carrier protein TusA;
end case
Gene name Name=tusA;

Comments [?]

case <OC:Enterobacterales>
FUNCTIONSulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
SUBUNITInteracts with IscS.
PATHWAYtRNA modification.
FUNCTIONSulfur carrier protein which probably makes part of a sulfur- relay system.
end case
SIMILARITYBelongs to the sulfur carrier protein TusA family.

Keywords [?]

case <OC:Enterobacterales>
tRNA processing
end case

Gene Ontology [?]

GO:0097163; Molecular function:sulfur carrier activity
case <OCellular component:Enterobacterales>
GO:0006400; Biological process:tRNA modification
end case
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS01148; UPF0033; 1;
Pfam PF01206; TusA; 1;

Features [?]

From: TUSA_ECOLI (P0A890)
Key From To Description Tag Condition FTGroup
ACT_SITE 19 19 /note="Cysteine persulfide intermediate" C

Additional information [?]

Size range 76-84 amino acids
Related rules None
Fusion Nter: None Cter: None

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