HAMAP logo

HAMAP rule MF_00413

Send feedback

General rule information [?]

Accession MF_00413
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 23)
Name Thiourid_synth_A
Bacteria; Gammaproteobacteria
Template P0A890 (TUSA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Protein name
RecName: Full=Sulfur carrier protein TusA;
AltName: Full=Sulfur mediator TusA;
AltName: Full=Sulfur transfer protein TusA;
AltName: Full=tRNA 2-thiouridine synthesizing protein A;
Protein name
RecName: Full=Sulfur carrier protein TusA;
end case
Gene name

Comments [?]

case <OC:Enterobacterales>
Function Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
Subunit Interacts with IscS.
Pathway tRNA modification.
Function Sulfur carrier protein which probably makes part of a sulfur-relay system.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the sulfur carrier protein TusA family.

Keywords [?]

case <OC:Enterobacterales>
end case

Gene Ontology [?]

GO:0097163; Molecular function: sulfur carrier activity.
case <OC:Enterobacterales>
GO:0008033; Biological process: tRNA processing.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS01148; UPF0033; 1;
Pfam PF01206; TusA; 1;

Features [?]

From: TUSA_ECOLI (P0A890)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     19     19       Cysteine persulfide intermediate     C  

Additional information [?]

Size range 76-84 amino acids
Related rules None
Fusion None