HAMAP rule MF_00413
General rule information
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| Accession | MF_00413 |
| Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 23) |
| Name | Thiourid_synth_A |
| Scope | Bacteria; Gammaproteobacteria |
| Template | P0A890 (TUSA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
case <OC:Enterobacterales>
| Protein name |
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else
| Protein name |
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end case
| Gene name |
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Comments
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case <OC:Enterobacterales>
| Function | Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin. |
| Subunit | Interacts with IscS. |
| Pathway | tRNA modification. |
else
| Function | Sulfur carrier protein which probably makes part of a sulfur-relay system. |
end case
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the sulfur carrier protein TusA family. |
Keywords
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case <OC:Enterobacterales>
end case
Gene Ontology
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GO:0097163; Molecular function: sulfur carrier activity.
case <OC:Enterobacterales>
GO:0008033; Biological process: tRNA processing.
end case
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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| From: TUSA_ECOLI (P0A890) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 19 | 19 | Cysteine persulfide intermediate | C | ||||||||
Additional information
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| Size range | 76-84 amino acids |
| Related rules | None |
| Fusion | None |