HAMAP rule MF_00417

General rule information [?]

Accession	MF_00417
Dates	19-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 25)

Name	Pyrrolid_peptidase

Scope

Bacteria

Archaea

Templates

P46107 (PCP_BACAM); P28618 (PCP_BACSU); O07883 (PCP_THELN): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PCP

Protein name

RecName:		Full=Pyrrolidone-carboxylate peptidase;
		EC 3.4.19.3;
AltName:		Full=5-oxoprolyl-peptidase;
AltName:		Full=Pyroglutamyl-peptidase I;
		Short=PGP-I;
		Short=Pyrase;

Gene name

pcp

Comments [?]

Function	Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
Catalytic activity	Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3;
Subunit	Homotetramer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the peptidase C15 family.

Keywords [?]

Gene Ontology [?]

GO:0016920; Molecular function: pyroglutamyl-peptidase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Features [?]

From: PCP_BACAM (P46107)

Key From To Description Tag Condition FTGroup

ACT_SITE 81 81 E

ACT_SITE 144 144 C

ACT_SITE 168 168 H

Additional information [?]