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HAMAP rule MF_00417

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General rule information [?]

Accession MF_00417
Dates 19-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 25)
Name Pyrrolid_peptidase
Scope(s) Bacteria
Archaea
Template(s) P46107 (PCP_BACAM); P28618 (PCP_BACSU); O07883 (PCP_THELN); [ Recover all ]
Triggered by HAMAP; MF_00417 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PCP
Protein name RecName: Full=Pyrrolidone-carboxylate peptidase;
                 EC=3.4.19.3;
AltName: Full=5-oxoprolyl-peptidase;
AltName: Full=Pyroglutamyl-peptidase I;
                 Short=PGP-I;
                 Short=Pyrase;
Gene name Name=pcp;

Comments [?]

FUNCTIONRemoves 5-oxoproline from various penultimate amino acid residues except L-proline.
CATALYTIC ACTIVITY Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3;
SUBUNITHomotetramer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the peptidase C15 family.

Keywords [?]


Gene Ontology [?]

GO:0016920; Molecular function:pyroglutamyl-peptidase activity
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01470; Peptidase_C15; 1;
PRINTS PR00706; PYROGLUPTASE; 1;
NCBIfam TIGR00504; Pyro_pdase; 1;
PROSITE PS01333; PYRASE_GLU; 1;
PROSITE PS01334; PYRASE_CYS; 1;

Features [?]

From: PCP_BACAM (P46107)
Key From To Description Tag Condition FTGroup
ACT_SITE 81 81 E
ACT_SITE 144 144 C
ACT_SITE 168 168 H

Additional information [?]

Size range 200-222 amino acids
Related rules None
Fusion Nter: None Cter: None



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