HAMAP rule MF_00417
General rule information
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| Accession | MF_00417 |
| Dates | 19-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 26) |
| Name | Pyrrolid_peptidase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P46107 (PCP_BACAM); P28618 (PCP_BACSU); O07883 (PCP_THELN); [ Recover all ] |
| Triggered by |
HAMAP; MF_00417 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PCP |
| Protein name | RecName: Full=Pyrrolidone-carboxylate peptidase; EC=3.4.19.3; AltName: Full=5-oxoprolyl-peptidase; AltName: Full=Pyroglutamyl-peptidase I; Short=PGP-I; Short=Pyrase; |
| Gene name | Name=pcp; |
Comments
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| FUNCTION | Removes 5-oxoproline from various penultimate amino acid residues except L-proline. |
| CATALYTIC ACTIVITY | Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3; |
| SUBUNIT | Homotetramer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the peptidase C15 family. |
Keywords
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Gene Ontology
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| GO:0016920; Molecular function:pyroglutamyl-peptidase activity |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01470; Peptidase_C15; 1; |
| PRINTS | PR00706; PYROGLUPTASE; 1; |
| NCBIfam | TIGR00504; Pyro_pdase; 1; |
| PROSITE | PS01333; PYRASE_GLU; 1; |
| PROSITE | PS01334; PYRASE_CYS; 1; |
Features
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| From: PCP_BACAM (P46107) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 81 | 81 | E | |||||||||
| ACT_SITE | 144 | 144 | C | |||||||||
| ACT_SITE | 168 | 168 | H | |||||||||
Additional information
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| Size range | 200-222 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |