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Annotation rule MF_00417
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General rule information [?]

Accession MF_00417
Dates 19-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 24)
Name Pyrrolid_peptidase
Scope
Bacteria
Archaea
Templates P46107 (PCP_BACAM); P28618 (PCP_BACSU); O07883 (PCP_THELN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PCP
Protein name
RecName: Full=Pyrrolidone-carboxylate peptidase;
EC 3.4.19.3;
AltName: Full=5-oxoprolyl-peptidase;
AltName: Full=Pyroglutamyl-peptidase I;
Short=PGP-I;
Short=Pyrase;
Gene name
pcp

Comments [?]

Function Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
Catalytic activity Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3;
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the peptidase C15 family.

Keywords [?]

Cytoplasm
Hydrolase
Protease
Thiol protease

Gene Ontology [?]

GO:0016920; Molecular function: pyroglutamyl-peptidase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01470; Peptidase_C15; 1;
PRINTS PR00706; PYROGLUPTASE; 1;
TIGRFAMs TIGR00504; Pyro_pdase; 1;
PROSITE PS01333; PYRASE_GLU; 1;
PS01334; PYRASE_CYS; 1;

Features [?]

From: PCP_BACAM (P46107)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     81     81             E  
ACT_SITE     144     144             C  
ACT_SITE     168     168             H  

Additional information [?]

Size range 200-222 amino acids
Related rules None
Fusion None


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